DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh2 and Aldh1a2

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_033048.2	Gene:	Aldh1a2 / 19378	MGIID:	107928	Length:	518	Species:	Mus musculus

Alignment Length:	510	Identity:	124/510 - (24%)
Similarity:	218/510 - (42%)	Gaps:	84/510 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 VEHVPIVINGQEFQAKED---FQQVLPYDIQQPIAHYGHAHRVLIQMAIDKSVEAQ-------VK 133
            :::..|.|| .|:|..|.   |....|...:| :.....|.:|    .|||:|:|.       ..
Mouse    35 IKYTKIFIN-NEWQNSESGRVFPVCNPATGEQ-VCEVQEADKV----DIDKAVQAARLAFSLGSV 93

  Fly   134 WDKVRLSDRIDIWERAAMLIAGRYRYNIIAATMLGQGKTLRQA-EMDVAELVDFMRIN------- 190
            |.::..|:|..:.::.|.|:. |.|..:.....|..||...|| .:|:..::..:|..
Mouse    94 WRRMDASERGRLLDKLADLVE-RDRATLATMESLNGGKPFLQAFYIDLQGVIKTLRYYAGWADKI 157

  Fly   191 -----PV------FLRELANYEPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTGIAANLAYTPAL 244
                 ||      |.|    :|||                 |....|.|:||..:.......|||
Mouse   158 HGMTIPVDGDYFTFTR----HEPI-----------------GVCGQIIPWNFPLLMFTWKIAPAL 201

  Fly   245 -MGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPKLAGINFTGTST 308
             .||:|:.||::...||..::...::|||.|.||||.:|....|..:.:..|..:..|.|||::.
Mouse   202 CCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVVNILPGYGPTAGAAIASHIGIDKIAFTGSTE 266

  Fly   309 VLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEYAGQKCSSCSML 373
            |.|::.:...::     |..|:..|.|||:.:.:.:.|:.:.||....:..|...||.|::.|.:
Mouse   267 VGKLIQEAAGRS-----NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRI 326

  Fly   374 YVPESLWQNHIREPLLEITASLVVRQ-DATYCDSFCSAVINRRAYDRIYMWLRYIDQ--SPSCQI 435
            :|.||:::..::..:......:|... |.|   :.....|:::.|:::   |..|..  :...::
Mouse   327 FVEESIYEEFVKRSVERAKRRIVGSPFDPT---TEQGPQIDKKQYNKV---LELIQSGVAEGAKL 385

  Fly   436 LVGGSCDKRRGYYVDPTVVLVKDLDNIICREELLAPILGVYVYPDHKLKETMEKVAQINHGLTGS 500
            ..||....|:|::::|||......|..|.:||:..|:..:..:  ..:.|.:|:....:.||..:
Mouse   386 ECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRF--KTMDEVIERANNSDFGLVAA 448

  Fly   501 VFAQDQN---FIEEAYDAFRVNVGNLNVNDKSTGLMVGQQPFGAGHMTGTSDKLG 552
            ||..|.|   .:..|..|..|.:...|.       :..|.|||...|:|...::|
Mouse   449 VFTNDINKALMVSSAMQAGTVWINCYNA-------LNAQSPFGGFKMSGNGREMG 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	124/510 (24%)
Aldh1a2	NP_033048.2	ALDH_F1AB_F2_RALDH1	32..512	CDD:143459	124/510 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810