DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh2 and alh-3

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_502054.2	Gene:	alh-3 / 177999	WormBaseID:	WBGene00000109	Length:	908	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	119/551 - (21%)
Similarity:	204/551 - (37%)	Gaps:	146/551 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 VEHVPIVINGQEFQAK-----------------EDFQQVLPYDIQQPIAHYGHAHRVLIQMA-ID 125
            |.:.|||:|....:.|                 ..|:.:.| ..::||...     .|..:| :|
Worm   410 VTYDPIVLNVNNMELKFPHDQFIDGKFVGSSDGRTFKTINP-ATEKPICEL-----PLATVADVD 468

  Fly   126 KSVEAQVK------WDKVRLSDRIDIWERAAMLI--------------AGRYRYNIIAATMLG-- 168
            ::|.|..|      |.::...:|.....:.|.|:              ||.. |.:...|.:|
Worm   469 RAVRAAKKAFERGEWRQMSARERGKRLYKLAELMEEHKEELATLESLDAGAV-YTLALKTHVGMS 532

  Fly   169 --------------QGKTLRQAEMDVAELVDFMRINPVFLRELANYEPIRDIQNNCRNSMRLRGL 219
                          ||||:                            ||.:.:.|....:.||..
Worm   533 IDVWRYFAGWCDKIQGKTI----------------------------PISNARPNKNLCLTLREP 569

  Fly   220 SGFVAAISPFNFT------GIAANLAYTPALMGNSVIWKPSDSAILSNYFVFKALREAGVPDGVV 278
            .|.|..|:|:|:.      .:||.||     .||:|:.||:....|:.....:....||:|.||:
Worm   570 IGVVGLITPWNYPLMMLSWKMAACLA-----AGNTVVHKPAQVTPLTALKFAELSVLAGIPPGVI 629

  Fly   279 NFVPAEETTFASVVTQHPKLAGINFTGTSTVLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVH 343
            |.|....:...:.:|.||.:..|.|||::.:...:.:..|::     |..::..|.|||:...:.
Worm   630 NIVTGSGSLVGNRLTAHPDVRKIGFTGSTEIGATVMESCAKS-----NIKKVSLELGGKSPLIIF 689

  Fly   344 SSAEPETAVACTIRAAFEYAGQKCSSCSMLYVPESLW------------QNHIREPLLEITASLV 396
            :.|:.|.||.....|.|...|:.|.:...:::.:|:.            |..|.:||...||
Worm   690 ADADLEKAVKQACGAVFFNKGENCIAAGRVFIAKSIHDDFVKKLVEEAKQYQIGDPLDRSTA--- 751

  Fly   397 VRQDATYCDSFCSAVINRRAYDRIYMWLRYIDQSPS--CQILVGGSCDKRRGYYVDPTVVLVKDL 459
                        ....|..|:  :...:.|::::.:  .::.|||...:|.|.|..||::...|.
Worm   752 ------------HGPQNHLAH--LNKLVEYVEKAVAGGAKVEVGGKRLEREGLYFPPTILSNIDD 802

  Fly   460 DNIICREELLAPILGVYVYPDHKLKETMEKVAQINHGLTGSVFAQDQN---FIEEAYDAFRVNVG 521
            :|....||...||:.|..:.|..:::.:.:......||...||.:|.:   .:.||..|..|.|.
Worm   803 ENFAASEESFGPIMCVSSFDDDDIEDVLRRANDTEFGLAAGVFTRDSSKSLRVAEALHAGTVFVN 867

  Fly   522 NLNVNDKSTGLMVGQQPFGAGHMTGTSDKLG 552
            .....|.:.       |||....:|....:|
Worm   868 TYQKTDVAA-------PFGGFKQSGFGKDMG 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	119/551 (22%)
alh-3	NP_502054.2	fmt	1..318	CDD:273088
		FMT_core_FDH_N	1..209	CDD:187716
		FDH_Hydrolase_C	214..315	CDD:187731
		PP-binding	335..393	CDD:278949
		ALDH-SF	423..908	CDD:299846	114/538 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810