DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P5CDh2 and aldh1a2

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_571925.1	Gene:	aldh1a2 / 116713	ZFINID:	ZDB-GENE-011010-3	Length:	518	Species:	Danio rerio

Alignment Length:	494	Identity:	120/494 - (24%)
Similarity:	206/494 - (41%)	Gaps:	98/494 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 IDKSVEAQVK-------WDKVRLSDRIDIWERAAMLIAGRYRYNIIAATM--LGQGKT-LRQAEM 178
            :||:|:|...       |.|:..|:|..:..:.|.|:.   |.:...||:  |..||. |....:
Zfish    77 VDKAVQAARSAFSLGSVWRKMDASERGKLLFKLADLVE---RDSAYLATLESLDSGKPFLPCFFV 138

  Fly   179 DVAELVDFMR---------------INPVFLRELANYEPIRDIQNNCRNSMRLRGLSGFVAAISP 228
            |:..::...|               |:..|. .|..:|||                 |....|.|
Zfish   139 DLQGIIKTFRYYAGWADKIHGSTIPIDGEFF-TLTRHEPI-----------------GVCGQIIP 185

  Fly   229 FNFTGIAANLAYTPAL-MGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVV 292
            :||..:.......||| .||:|:.||::...|:..::...::|||.|.||||.:|....|..:.:
Zfish   186 WNFPLVMTAWKLGPALSCGNTVVLKPAEQTPLTCLYLGALIKEAGFPPGVVNILPGYGPTAGAAI 250

  Fly   293 TQHPKLAGINFTGTSTVLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIR 357
            :.|..:..:.|||::.|.|::.:...::     |..|:..|.|||:.:.:.:.|:.|.|:....:
Zfish   251 SSHMGIDKVAFTGSTEVGKLIQEAAGKS-----NLKRVTLELGGKSPNIIFADADFELALEQAHQ 310

  Fly   358 AAFEYAGQKCSSCSMLYVPESLWQNHIR---------------EPLLEITASLVVRQDATYCDSF 407
            ..|...||.|::.|.::|.|.::...:|               :|..|....:...|
Zfish   311 GVFFNNGQCCTAGSRIFVEEPIYDEFVRRSVERAQRRKVGNPFDPTTEHGPQVSEEQ-------- 367

  Fly   408 CSAVINRRAYDRIYMWLRYIDQSPSCQILVGGSCDKRRGYYVDPTVVL-VKDLDNIICREELLAP 471
                 .||..:.|...:     :...::..||.....:|::|:|||.. ||| ...|.:||:..|
Zfish   368 -----QRRVLELIQSGI-----TEGAKLECGGKAPATKGFFVEPTVFSNVKD-HMRIAKEEIFGP 421

  Fly   472 ILGVYVYPDHKLKETMEKVAQINHGLTGSVFAQDQNFIEEAYD-AFRVNVGNLNVNDKSTGLMVG 535
            :..:..:  ..::|.:|:.....:||..:||.:|   |.:|.. :..|..|.:.:|  ....|..
Zfish   422 VQQIMKF--KTIEEVIERANNTEYGLAAAVFTRD---ISKAMTISAAVQAGTVWIN--CYNAMSC 479

  Fly   536 QQPFGAGHMTGTSDKLGTPHSLLRWTSPQVI--KESYKT 572
            |.|||...|:|...:|| ...|..:|..:.|  |.|.||
Zfish   480 QCPFGGFKMSGNGRELG-EIGLKEYTELKTITMKMSGKT 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	117/490 (24%)
aldh1a2	NP_571925.1	ALDH_F1AB_F2_RALDH1	32..512	CDD:143459	116/487 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810