Protein Alignment P5CDh2 and Aldh2

DIOPT Version :10

• Sequence 1: NP_788705.1
• Gene: P5CDh2 / 32625
• FlyBaseID: FBgn0053092
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_033786.1
• Gene: Aldh2 / 11669
• MGIID: 99600
• Length: 519
• Species: Mus musculus
• Alignment Length: 556
• Identity: 140/556 - (25%)
• Similarity: 220/556 - (39%)
• Gaps: 121/556 - (21%)

  Fly    68 LETALLGVLNRVEHVP------IVINGQEFQA--KEDFQQVLPYDIQQPIAHYGHAHRVLIQMA- 123
            |..|....:....|.|      |.||.:...|  ::.|..|.|           ....|:.|:|
Mouse    19 LSAAATSAVPAPNHQPEVFCNQIFINNEWHDAVSRKTFPTVNP-----------STGEVICQVAE 72

  Fly   124 -----IDKSVEAQ-------VKWDKVRLSDRIDIWERAAMLIAGRYRYNIIAATMLGQGKTLRQA 176
                 :||:|:|.       ..|.::..|||..:..|.|.||. |.|..:.|...|..||
Mouse    73 GNKEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIE-RDRTYLAALETLDNGK----- 131

  Fly   177 EMDVAELVDF---------------------MRINPVFLRELANYEPIRDIQNNCRNSMRLRGLS 220
            ...::.|||.                     :.|:..|. ....:||:
Mouse   132 PYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFF-SYTRHEPV----------------- 178

  Fly   221 GFVAAISPFNFTGIAANLAYTPAL-MGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAE 284
            |....|.|:||..:.......||| .||.|:.|.::...|:..:|...::|||.|.||||.||..
Mouse   179 GVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGF 243

  Fly   285 ETTFASVVTQHPKLAGINFTGTSTVLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPE 349
            ..|..:.:..|..:..:.||| ||.:..|.|:.|.:    .|..|:..|.|||:.:.:.|.|:.:
Mouse   244 GPTAGAAIASHEGVDKVAFTG-STEVGHLIQVAAGS----SNLKRVTLELGGKSPNIIMSDADMD 303

  Fly   350 TAVACTIRAAFEYAGQKCSSCSMLYVPESLWQNHIREPLLEITASLVVRQDATYCDSFCSAV--- 411
            .||.....|.|...||.|.:.|..:|.|:::...:...:....:.:|       .:.|.|..
Mouse   304 WAVEQAHFALFFNQGQCCCAGSRTFVQENVYDEFVERSVARAKSRVV-------GNPFDSRTEQG 361

  Fly   412 --INRRAYDRIYMWLRYI--DQSPSCQILVGGSCDKRRGYYVDPTVV-LVKDLDNIICREELLAP 471
              ::...:.:|   |.||  .|....::|.||.....|||::.|||. .||| ...|.:||:..|
Mouse   362 PQVDETQFKKI---LGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKD-GMTIAKEEIFGP 422

  Fly   472 ILGVYVYPDHKLKETMEKVAQIN---HGLTGSVFAQD---QNFIEEAYDAFRVNVGNLNVNDKST 530
            ::.:.     |.|...|.|.:.|   :||..:||.:|   .|::.:|..|..|.:...:|
Mouse   423 VMQIL-----KFKTIEEVVGRANDSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDV----- 477

  Fly   531 GLMVGQQPFGAGHMTGTSDKLGTPHSLLRWTSPQVI 566
              ...|.|||...|:|:..:|| .:.|..:|..:.:
Mouse   478 --FGAQSPFGGYKMSGSGRELG-EYGLQAYTEVKTV 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:448367	140/556 (25%)
Aldh2	NP_033786.1	SIFI-degron. /evidence=ECO:0000250|UniProtKB:P05091	12..26		2/6 (33%)
		ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	137/542 (25%)