Protein Alignment P5CDh2 and ALDH1L1

DIOPT Version :10

• Sequence 1: NP_788705.1
• Gene: P5CDh2 / 32625
• FlyBaseID: FBgn0053092
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_001257293.1
• Gene: ALDH1L1 / 10840
• HGNCID: 3978
• Length: 912
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 134/622 - (21%)
• Similarity: 234/622 - (37%)
• Gaps: 135/622 - (21%)

  Fly     6 AHGIVSNMRSILPR-LEAS-----VKGGLVS---VRSTSKRPELSEHFTL---DEMVAN------ 52
            |..:.|..:.|||: ||..     .|.|..|   ||...:..||.:...|   |..:|:
Human   334 AEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRLVEEVKELCDGLELENEDVYMASTFGDFI 398

  Fly    53 EKLLQYDEGSKERTE--LETALLGVLNRVEHVP--IVINGQ--EFQAKEDFQQVLPYDIQQPIAH 111
            :.|::...|..|..|  ::...:.|..|...:|  :.|.|:  :.:..:..:.:.|.|
Human   399 QLLVRKLRGDDEEGECSIDYVEMAVNKRTVRMPHQLFIGGEFVDAEGAKTSETINPTD------- 456

  Fly   112 YGHAHRVLIQMA------IDKSVEA------QVKWDKVRLSDRIDIWERAAMLIAGRYRYNIIAA 164
                ..|:.|::      :||:|.|      ..:|.|:...||            ||..|.:  |
Human   457 ----GSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDR------------GRLMYRL--A 503

  Fly   165 TMLGQGKTLRQAEMDVAELVDFMRINPVFLRELANYE-------------------PIRDIQNNC 210
            .::.|    .|.|:...|.:|...:..:.|:......                   ||...:.|.
Human   504 DLMEQ----HQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNR 564

  Fly   211 RNSMRLRGLSGFVAAISPFNFT------GIAANLAYTPALMGNSVIWKPSDSAILSNYFVFKALR 269
            ..::..:...|....|.|:|:.      ..||.||     .||:|:.||:....|:.....:...
Human   565 NLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLA-----AGNTVVIKPAQVTPLTALKFAELTL 624

  Fly   270 EAGVPDGVVNFVPAEETTFASVVTQHPKLAGINFTGTSTVLKVLWQLVAQNINFYQNYPRLVGEG 334
            :||:|.||||.:|...:.....::.||.:..|.|||::.|.|.:.:..|     ..|..::..|.
Human   625 KAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCA-----ISNVKKVSLEL 684

  Fly   335 GGKNFHFVHSSAEPETAVACTIRAAFEYAGQKCSSCSMLYVPESLWQNHIREPLLEITASLV--- 396
            |||:...:.:..:...||...:.:.|...|:.|.:...|:|.:|:....:|..:.|:....|
Human   685 GGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNP 749

  Fly   397 VRQDATYCDSFCSAVINRRAYDRIYMWLRYIDQSPSCQ--------ILVGGSCDKRRGYYVDPTV 453
            :.:|..:...      |..|:  :...:.|      ||        ::.||:...|.|::.:|||
Human   750 LDRDTDHGPQ------NHHAH--LVKLMEY------CQHGVKEGATLVCGGNQVPRPGFFFEPTV 800

  Fly   454 VLVKDLDNIICREELLAPILGVYVYPDHKLKETMEKVAQINHGLTGSVFAQDQN---FIEEAYDA 515
            ....:....|.:||...|::.:..:.|..|...:.:......||...||.:|.|   ::.:...|
Human   801 FTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQA 865

  Fly   516 FRVNVGNLNVNDKSTGLMVGQQPFGAGHMTGTSDKLG 552
            ..|.|...|..|.:.       |||....:|....||
Human   866 GTVFVNTYNKTDVAA-------PFGGFKQSGFGKDLG 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:448367	118/566 (21%)
ALDH1L1	NP_001257293.1	FMT_core_FDH_N	11..213	CDD:187716
		FDH_Hydrolase_C	216..316	CDD:187731
		ALDH_F1L_FTFDH	427..912	CDD:143458	111/529 (21%)