DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh2 and aldh9a1a.1

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_958879.1	Gene:	aldh9a1a.1 / 100005587	ZFINID:	ZDB-GENE-030131-1257	Length:	508	Species:	Danio rerio

Alignment Length:	527	Identity:	128/527 - (24%)
Similarity:	224/527 - (42%)	Gaps:	115/527 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 EFQAKEDFQQVLPYDIQQPIAHYGHAH------------------RVLIQM----------AIDK 126
            |||:......|    :::|:..:|.|.                  |||..|          ||..
Zfish    11 EFQSVSTGTLV----VKEPLNFWGGARVKPRDTKNSEPVYEPATGRVLCDMIPCGEEEVDQAIKS 71

  Fly   127 SVEAQVKWDKVRLSDRIDIWERAAMLIAGRYRYNIIA-ATMLGQGKTLRQAEMDVA---ELVDFM 187
            :..|.:||.::...:|..|...||.:|  |.|.|.|| |.:...||::.:||:|:.   :.:::
Zfish    72 AHSAYLKWSQLSGMERSRIMLEAARII--RERRNAIAKAEVANNGKSITEAEVDIDVAWQCIEY- 133

  Fly   188 RINPVFLRELANYEPIRDIQNNCRNSMRLRGLS---------GFVAAISPFNFTGIAANLAYTPA 243
                     .|...|....|:     ::|.|.|         |....|..:|:....|.....||
Zfish   134 ---------YAGIAPTLSGQH-----IQLPGGSFAYTRREPLGVCVGIGAWNYPFQIAAWKSAPA 184

  Fly   244 L-MGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPKLAGINFTGTS 307
            | .||::::|||....::...:.:..:|||||||:.|.|.....| .|::..||.:|.::|||:.
Zfish   185 LACGNAMVFKPSPMTPVTAVMLAEIYKEAGVPDGLFNVVQGGAET-GSLLCHHPMVAKVSFTGSV 248

  Fly   308 TVLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEYAGQKCSSCSM 372
            ...|.:.::.|:::.      ::..|.|||:...:....|.|.|:...:.|.|...|:.|.:.:.
Zfish   249 PTGKKVMEMAAKSVK------QVTLELGGKSPLIIFKDCELENAIKGALMANFLTQGEVCCNGTR 307

  Fly   373 LYVPESLWQNHIREPLLEITASLVVRQDATYCDSFC-----SAVINRRAYDRIYMWLRYIDQS-- 430
            ::|...:....:.| :::.|.::.|.      |..|     .|:|::...:::   |.:|.|:
Zfish   308 VFVQREIMPKFLEE-VVKRTKAISVG------DPLCEGTRMGALISKPHMEKV---LGFIKQAKE 362

  Fly   431 PSCQILVGG------SCDKRRGYYVDPTVVLVKDLDNIICR-------EELLAPILGVYVYPDHK 482
            ...::|.||      ....:.||:|.|.|     |||  ||       ||:..|::.  |.|...
Zfish   363 QGGKVLCGGERFVPNDPKLKDGYFVSPCV-----LDN--CRDDMTCVKEEIFGPVMS--VLPFDT 418

  Fly   483 LKETMEKVAQINHGLTGSVFAQDQNFIEEAYD-AFRVNVGNLNVNDKSTGLMVGQQPFGAGHMTG 546
            .:|.:::......||...||.:|   |..|:. |..:..|...:|:.:.|.:  :.|||...|:|
Zfish   419 EEEVLQRANNTTFGLASGVFTRD---IARAHRVAANLQAGTCYINNYNVGPV--EVPFGGYKMSG 478

  Fly   547 TSDKLGT 553
            ...:.||
Zfish   479 FGRENGT 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	128/527 (24%)
aldh9a1a.1	NP_958879.1	ALDH_F9_TMBADH	45..502	CDD:143409	121/489 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810