DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gorab and GORAB

DIOPT Version :9

Sequence 1:	NP_788523.1	Gene:	Gorab / 326245	FlyBaseID:	FBgn0053052	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	XP_011508451.1	Gene:	GORAB / 92344	HGNCID:	25676	Length:	377	Species:	Homo sapiens

Alignment Length:	321	Identity:	85/321 - (26%)
Similarity:	147/321 - (45%)	Gaps:	92/321 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 RRMPDKIFRQADQLRK---QQQQQ-----------PQQ----PIQKPDVAKKTKSGTATPTEKPP 91
            ||:|.|..||..|..|   :|.|:           |:|    |.|:.:|            :|||
Human    35 RRLPAKKSRQQLQREKALVEQSQKLGLQDGSTSLLPEQLLSAPKQRVNV------------QKPP 87

  Fly    92 TPTPAAEDDVANGSLNLDRPLSDSLIEALYHGNATARDKKTPATYADAETTSTDDSSILKISGGD 156
            ..:|...     ....|..|:.|.                                   :..|.:
Human    88 FSSPTLP-----SHFTLTSPVGDG-----------------------------------QPQGIE 112

  Fly   157 SQT----TSSTDDG----SILPSTQDTSPRERLNTDSPFKGISLKD------FEQHRRMIEEQNK 207
            ||.    ..::.||    .|||...|....:        |.:.|::      .:|.:|::||:||
Human   113 SQPKELGLENSHDGHNNVEILPPKPDCKLEK--------KKVELQEKSRWEVLQQEQRLMEEKNK 169

  Fly   208 QKKQMLYQAIEQHTQKTAAESRKIEEIRHELSKLESDLAVDVALLRKQIDNACIHFANVEKQYVK 272
            :||.:|.:||.:.:::|.||:.|::.|:.||..|:..::.|:.:||.:||.|.:.::...|::.:
Human   170 RKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDR 234

  Fly   273 IEAQFLRAKIELHNASEKKELLTEHLCTVIAHNEDRKAQKLTELMQKVGLSPTDDCQPIDL 333
            .||:::.||:::...:|.||.|||||||:|..||.|||:||.||||::.:...::...:::
Human   235 AEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEV 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gorab	NP_788523.1	Transcrip_act	<200..316	CDD:309879	47/115 (41%)
GORAB	XP_011508451.1	Transcrip_act	<162..283	CDD:282763	51/120 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146838
Domainoid	1	1.000	111	1.000	Domainoid score	I6290
eggNOG	1	0.900	-	-		E1_28Z6D
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1277705at2759
OrthoFinder	1	1.000	-	-		FOG0007411
OrthoInspector	1	1.000	-	-		oto88826
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21470
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5201
SonicParanoid	1	1.000	-	-		X5537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.840