DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32985 and T07G12.3

DIOPT Version :9

Sequence 1:	NP_788013.2	Gene:	CG32985 / 326244	FlyBaseID:	FBgn0052985	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_501945.2	Gene:	T07G12.3 / 188242	WormBaseID:	WBGene00011594	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	161/696 - (23%)
Similarity:	280/696 - (40%)	Gaps:	148/696 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LIVSFLAVTLICLWSMNSSRVDENFSARDSQEVE-KLFYVESGK-----CKMRYVNPFNAEFLKI 70
            ::::||...::...|.|:.          |.::| |..|::|.:     |.:...:.::.....:
Worm    10 ILLAFLGFYMLSWRSFNNG----------STKIESKFLYLDSSRSAHNICALPIYDYWDTSIKNV 64

  Fly    71 NHPKAFIPCTNESDLISVHYDKILNQYVLHTNEEVLH---ELSESKTNDFA-CF-------YQKI 124
            .|  .:.|..|           ....||..|  |:::   .:.:...|..| ||       ..||
Worm    65 MH--EYNPARN-----------CYKNYVQWT--ELVNSTWRIVKDGANCLARCFSGIGGSKNVKI 114

  Fly   125 IYGQSAEHYDGKGVKTKISQNHLVPLDVEGMLVECRTADEMRVLQRDAFVFVQYKDPPQNVKPVK 189
            .......|.|.:.::|...:::   ::|.|.:       ..:::.|.|.. .::||.|
Worm   115 GPWMKPGHVDCEFLETVCWEDN---IEVYGHI-------HTQIIPRKASP-TKFKDAP------- 161

  Fly   190 KASVIMYGIDTVSRTNLRRMMPMVFEFLKSPGWYEMMGY---NKVADNSFPNIFAMLTGFSPESA 251
              :|.::.||.::....:|..|.:..:.|:.  ::|:.:   |||.:||.||...:..|.|.|..
Worm   162 --NVFIFTIDAMNTGMAKRSFPKLLSYFKNE--FQMIEFPFVNKVGENSRPNGLPLWFGKSIEGG 222

  Fly   252 E-------------TQICNTDVDGCLDKIPFIWKDFKKDGYLTAYAEDEEHSNTFNYAK-PGFAV 302
            .             .|.|.|    .||....|:||||..||.|...||.|.:...::.. .||..
Worm   223 RRVTGDDVEVDWDWNQYCET----YLDNSSHIFKDFKDHGYATMLFEDWEGNVVDSWPTCVGFEE 283

  Fly   303 KPTDYYFRPFLTALEN---ETFIQYCPGCVMKYCLGRRLASSYIFDYCRQFMQRFVADRPIWGMF 364
            .|||:.||||.:..|.   |...::..|   |:|   |.....|.:...|.::.: .||||:...
Worm   284 PPTDHTFRPFASVSETHGMEITKRHLSG---KFC---RETHHAIMELLEQGIEAY-KDRPIFSWL 341

  Fly   365 WTNHYSHDDLFMLSAMQHKILEDLLSFEK--DGVFEHTIMIFFSDHGARFGPLMYTKEAFLEERL 427
            |....:||.:...:    ::.|.|:::.|  :.:|:::.::|.||||.|.|..|.|:....|...
Worm   342 WLAWVAHDWIDGAA----RVDEYLVNYFKKHNNMFDNSFVMFVSDHGLRTGKHMRTEIGAFERDN 402

  Fly   428 PMMFIYLPPWFRKKYPRYVEALAQNQNRLSSNFDLYNTLKHIINIEGL----------VEDTKWS 482
            |.:.|.:|..||......:|.|..:..:|.::||:..||..|:..:..          :.|.|.
Worm   403 PFLSISIPKRFRATKFGILETLNFDSKQLQTHFDVRATLLDILKFQPTSKFMDRQQKNIPDEKG- 466

  Fly   483 YDCPQCQSLFYPLPE-SRSCSEAAIPEAYCTC-------HNYEEIKEDQGTWRLANLVVDRMNKY 539
                  .||....|: .|:|:...||:.:|.|       || |.:|...|. :|.|.|..::.|.
Worm   467 ------HSLIRKQPDFPRTCATLPIPQQWCICQVDKFEIHN-ETLKNHLGE-KLLNHVHRKLKKL 523

  Fly   540 LHYHNLQNLCSNLTLRVINSTEVRMDDKDVDLANGMRHYHTKFQVHQNL---AEFFATVLYDKQT 601
                |:..:|....|..:.|.      .:......||.|  |..|...:   |.|...|.||.:|
Worm   524 ----NVSEICETFRLSKVTSL------IEYGYVRTMRTY--KISVETTISSYAHFETFVTYDIET 576

  Fly   602 EELQMNVELISRTNMYGTDSECVNNKIQKLYCVCLS---KLRAIIK 644
            :..:.  |.::|.:.|...::|.....|...|.|.:   .||.:::
Worm   577 DIAKF--EKVTRLDNYAMTTDCTKPIRQSPLCYCKNINFPLRILLR 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32985	NP_788013.2	DUF229	72..554	CDD:308570	129/532 (24%)
T07G12.3	NP_501945.2	DUF229	67..538	CDD:281053	129/533 (24%)
T07G12.3	NP_501945.2	ALP_like	161..448	CDD:293745	85/312 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100