DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pp2B-14D and PPT1

DIOPT Version :9

Sequence 1:	NP_001245715.1	Gene:	Pp2B-14D / 32624	FlyBaseID:	FBgn0011826	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_011639.3	Gene:	PPT1 / 853023	SGDID:	S000003355	Length:	513	Species:	Saccharomyces cerevisiae

Alignment Length:	346	Identity:	119/346 - (34%)
Similarity:	176/346 - (50%)	Gaps:	47/346 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 KLTLAEVFDQRTGKPNHEL--LKQHFI--------LEGR-IEEAPALKIIQDGAALLRQEKTMID 146
            ||...:::|.:......::  :.|.||        |:|: :.:.....||.....|.|||.:|::
Yeast   169 KLEFEQLYDDKNAFKGAKIKNMSQEFISKMVNDLFLKGKYLPKKYVAAIISHADTLFRQEPSMVE 233

  Fly   147 IE------APVTVCGDIHGQFYDLMKLFEVGG--SPASTKYLFLGDYVDRGYFSIECVLYLWSLK 203
            :|      ..::||||.||||||::.||...|  .|..| |||.||:||||.:|.|..|..:.||
Yeast   234 LENNSTPDVKISVCGDTHGQFYDVLNLFRKFGKVGPKHT-YLFNGDFVDRGSWSCEVALLFYCLK 297

  Fly   204 ITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGL 268
            |.:|...||.|||||..::.:.:.|:.|||.|||:|:::....:|:.||||.|:|..:|.:||||
Yeast   298 ILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGL 362

  Fly   269 -SPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACC 332
             |.....|.|.:.:|||.:||..|...:|||:||.|..|        ...|.||..:.:......
Yeast   363 PSDPSATLSDFKNIDRFAQPPRDGAFMELLWADPQEANG--------MGPSQRGLGHAFGPDITD 419

  Fly   333 DFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVL--------- 388
            .||:||.|..|.|:||.:..|.:..:|.:      |:|:||||||.|...|...|:
Yeast   420 RFLRNNKLRKIFRSHELRMGGVQFEQKGK------LMTVFSAPNYCDSQGNLGGVIHVVPGHGIL 478

  Fly   389 ---KYENNVMNIRQFNCSPHP 406
               :.::..:.|..|....||
Yeast   479 QAGRNDDQNLIIETFEAVEHP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2B-14D	NP_001245715.1	MPP_PP2B	107..411	CDD:277361	116/332 (35%)
PPT1	NP_011639.3	PLN03088	10..>130	CDD:215568
		TPR repeat	12..40	CDD:276809
		TPR repeat	45..75	CDD:276809
		TPR repeat	80..108	CDD:276809
		MPP_PP5_C	165..508	CDD:277362	119/346 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810