DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pp2B-14D and CNA1

DIOPT Version :9

Sequence 1:	NP_001245715.1	Gene:	Pp2B-14D / 32624	FlyBaseID:	FBgn0011826	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_013537.1	Gene:	CNA1 / 851153	SGDID:	S000004425	Length:	553	Species:	Saccharomyces cerevisiae

Alignment Length:	500	Identity:	269/500 - (53%)
Similarity:	355/500 - (71%)	Gaps:	43/500 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 VNTKERVVDSVPFPPSHKLTLAEVFDQRTGKPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQ 140
            ::||:|.:.|||.......:..||||.:||.|||..|::||..|||:.:..|:||:......|.:
Yeast    39 ISTKDRPIASVPAITGKIPSDEEVFDSKTGLPNHSFLREHFFHEGRLSKEQAIKILNMSTVALSK 103

  Fly   141 EKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKIT 205
            |..::.::||:|:|||||||:|||:|||||||.||...|||||||||||.||.||::||:|||:.
Yeast   104 EPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLN 168

  Fly   206 YPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP 270
            .....::|||||||:|||.|||||.|...||...|||||..:|:.||||||||.|:.|||||:||
Yeast   169 NLGRFWMLRGNHECKHLTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISP 233

  Fly   271 EIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDF-----GNE--KNSDFYTHNSVRGCSYFYSY 328
            |:..:||:.:::||:|.|:.|.||||||:||:|::     |:|  ::.|.:..||:||||:.:::
Yeast   234 ELKSVEDVNKINRFREIPSRGLMCDLLWADPVENYDDARDGSEFDQSEDEFVPNSLRGCSFAFTF 298

  Fly   329 AACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENN 393
            .|.|.||:.|.||||||||||||||||||:.::.||||||||:||||||||.|:|||||||||.|
Yeast   299 KASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKVTGFPSLITMFSAPNYLDTYHNKAAVLKYEEN 363

  Fly   394 VMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDEL--------------- 443
            |||||||:.||||||||:|||||||||||||||||.|||::|||||:.||
Yeast   364 VMNIRQFHMSPHPYWLPDFMDVFTWSLPFVGEKVTSMLVSILNICSEQELDPESEPKAAEETVKA 428

  Fly   444 ---MTEESEEPLSDDEAA-------LRKEVIRNKIRAIGKMARVFSVLREESESVLQLKGLTPTG 498
               .|:|:..| ||::|:       .|::.:||||.||.|::|:|||||||||.|..||.:. .|
Yeast   429 RANATKETGTP-SDEKASSAILEDETRRKALRNKILAIAKVSRMFSVLREESEKVEYLKTMN-AG 491

  Fly   499 ALPLGALSGGKQSLKNAMQGFSPNHKITSFAEAKGLDAVNERMPP 543
            .||.|||:.|.:.|         |..:::|.:|:..|.:||::||
Yeast   492 VLPRGALARGTEGL---------NETLSTFEKARKEDLINEKLPP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2B-14D	NP_001245715.1	MPP_PP2B	107..411	CDD:277361	186/310 (60%)
CNA1	NP_013537.1	MPP_PP2B	70..381	CDD:277361	186/310 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	277	1.000	Domainoid score	I262
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55497
Inparanoid	1	1.050	546	1.000	Inparanoid score	I170
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	1	1.000	-	-		mtm9223
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R954
SonicParanoid	1	1.000	-	-		X576
TreeFam	1	0.960	-	-
	14	13.860