DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pp2B-14D and ppp3ca

DIOPT Version :9

Sequence 1:	NP_001245715.1	Gene:	Pp2B-14D / 32624	FlyBaseID:	FBgn0011826	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001185479.1	Gene:	ppp3ca / 794574	ZFINID:	ZDB-GENE-091113-24	Length:	521	Species:	Danio rerio

Alignment Length:	518	Identity:	395/518 - (76%)
Similarity:	439/518 - (84%)	Gaps:	34/518 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 KLHGGHTAVNTKERVVDSVPFPPSHKLTLAEVFDQRTGKPNHELLKQHFILEGRIEEAPALKIIQ 132
            |:......:|:.:|||.|||||.||:||:.||||.. |||..:|||.|...|||:||..||:||.
Zfish     2 KMSNADMVLNSTDRVVKSVPFPLSHRLTMKEVFDCE-GKPRVDLLKAHLTKEGRVEETVALRIIN 65

  Fly   133 DGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVL 197
            :||::|||||||:||||||||||||||||:|||||||||||||:|:|||||||||||||||||||
Zfish    66 EGASILRQEKTMLDIEAPVTVCGDIHGQFFDLMKLFEVGGSPATTRYLFLGDYVDRGYFSIECVL 130

  Fly   198 YLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFL 262
            |||||||.||:||||||||||||||||||||||||||||||:|||:|||||||||||||||||||
Zfish   131 YLWSLKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSEQVYDSCMDAFDCLPLAALMNQQFL 195

  Fly   263 CVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYS 327
            ||||||||||..|:||::|||||||||||||||||||||||||||||:.::::||:|||||||||
Zfish   196 CVHGGLSPEIQTLDDIKKLDRFKEPPAFGPMCDLLWSDPLEDFGNEKSQEYFSHNTVRGCSYFYS 260

  Fly   328 YAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYEN 392
            |.|.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   261 YPAVCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYEN 325

  Fly   393 NVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEA 457
            |||||||||||||||||||||||||||||||||||||||||||:|||||||| .:.:|....:.|
Zfish   326 NVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELM-NDGDEIFDANAA 389

  Fly   458 ALRKEVIRNKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSLKN-------- 514
            |.||||||||||||||||::|||||||||:||.||||||||.||.|.|:||||:|::
Zfish   390 AARKEVIRNKIRAIGKMAKMFSVLREESENVLTLKGLTPTGMLPSGVLAGGKQTLQSATIEAIEA 454

  Fly   515 --------AMQGFSPNHKITSFAEAKGLDAVNERMPPRRDQPPTPSEDPNQHSQQGGKNGAGH 569
                    |::||||.|||:||.||||||.:|||||||:|                |.|..||
Zfish   455 IEEEEDTEAIRGFSPQHKISSFEEAKGLDRINERMPPRKD----------------GVNHVGH 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2B-14D	NP_001245715.1	MPP_PP2B	107..411	CDD:277361	266/303 (88%)
ppp3ca	NP_001185479.1	MPP_PP2B	40..344	CDD:277361	266/303 (88%)
ppp3ca	NP_001185479.1	PP2Ac	59..328	CDD:197547	240/268 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	402	1.000	Domainoid score	I693
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55497
Inparanoid	1	1.050	807	1.000	Inparanoid score	I469
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	1	1.000	-	-		mtm6407
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R954
SonicParanoid	1	1.000	-	-		X576
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870