DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pp2B-14D and ppp3cca

DIOPT Version :9

Sequence 1:	NP_001245715.1	Gene:	Pp2B-14D / 32624	FlyBaseID:	FBgn0011826	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_005171933.1	Gene:	ppp3cca / 557926	ZFINID:	ZDB-GENE-030829-36	Length:	508	Species:	Danio rerio

Alignment Length:	500	Identity:	379/500 - (75%)
Similarity:	432/500 - (86%)	Gaps:	12/500 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 VNTKERVVDSVPFPPSHKLTLAEVFDQRTGKPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQ 140
            ::|.||::.:||.||..:||:.:::..  ||||.||||.|.|.|||:||..||:||.|||.:|||
Zfish    10 LSTTERIIKTVPLPPHQRLTIKDLYVD--GKPNTELLKNHLIKEGRVEEDAALRIINDGANILRQ 72

  Fly   141 EKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKIT 205
            ||.|:::|||:|||||:||||:||||||||||||.:|:|||||||||||||||||||:||:|||.
Zfish    73 EKCMLEVEAPITVCGDVHGQFFDLMKLFEVGGSPDNTRYLFLGDYVDRGYFSIECVLFLWTLKIN 137

  Fly   206 YPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP 270
            :|.|||||||||||||||||||||||||||||||||||||:||||||||||:|||||||||||||
Zfish   138 HPNTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMEAFDCLPLAALLNQQFLCVHGGLSP 202

  Fly   271 EIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFL 335
            ||:.|:|||:||||||||||||||||:|:||.||:|:||.::.:.||||||||||:||||.||||
Zfish   203 EINCLDDIRKLDRFKEPPAFGPMCDLIWADPGEDYGSEKTAEHFNHNSVRGCSYFFSYAAVCDFL 267

  Fly   336 QNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF 400
            .||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   268 TNNNLLSVIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF 332

  Fly   401 NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEAALRKEVIR 465
            ||||||||||||||||||||||||||||||||||||||||||||: |.::.......|:||||||
Zfish   333 NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMS-EGDDLCEGGAPAVRKEVIR 396

  Fly   466 NKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSLKN---------AMQGFSP 521
            ||||||||||||||||||||||||.||||||||.||||.||||||:|:|         |:|||||
Zfish   397 NKIRAIGKMARVFSVLREESESVLTLKGLTPTGTLPLGVLSGGKQTLQNATIEAKEGRAIQGFSP 461

  Fly   522 NHKITSFAEAKGLDAVNERMPPRRDQPPTPSEDPNQHSQQGGKNG 566
            ..||.:|.||:|||.:|||||||:|.........|..:::.|.:|
Zfish   462 TRKIRNFEEARGLDRINERMPPRKDGQKPDGTTVNAANEKNGTDG 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2B-14D	NP_001245715.1	MPP_PP2B	107..411	CDD:277361	256/303 (84%)
ppp3cca	XP_005171933.1	MPP_PP2B	39..343	CDD:277361	256/303 (84%)
ppp3cca	XP_005171933.1	PP2Ac	59..327	CDD:197547	227/267 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	337	1.000	Domainoid score	I1077
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	807	1.000	Inparanoid score	I469
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	1	1.000	-	-		mtm6407
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R954
SonicParanoid	1	1.000	-	-		X576
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870