Protein Alignment Pp2B-14D and PPEF2

DIOPT Version :9

• Sequence 1: NP_001245715.1
• Gene: Pp2B-14D / 32624
• FlyBaseID: FBgn0011826
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_006230.2
• Gene: PPEF2 / 5470
• HGNCID: 9244
• Length: 753
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 119/545 - (21%)
• Similarity: 189/545 - (34%)
• Gaps: 199/545 - (36%)

  Fly    85 SVPFPPSHKLTLAEVFDQRTGKPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQEKTMIDIEA 149
            |.|..|.|...|.|.|..:      :.|...::|.                 ||.:.|..: ::.
Human   120 SFPLLPDHATALVEAFRLK------QQLHARYVLN-----------------LLYETKKHL-VQL 160

  Fly   150 P------------VTVCGDIHGQFYDLMKLFEVGGSPASTK-YLFLGDYVDRGYFSIECVLYLWS 201
            |            :|||||:|||..||:.:|...|.|:..: |:|.||:||||..|:|.::.|::
Human   161 PNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFA 225

  Fly   202 LKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKY---SERVYDACMDAFDCLPLAALMNQQFLC 263
            ..:.||:...|.|||||...:...:.|.:|...||   .:.:.....|.|..||||.|::::.|.
Human   226 FMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATLIDEKVLI 290

  Fly   264 VHGGLSPEIHELEDIRRLDRFK-------------------------EPPAFGPM---------- 293
            :|||:| :|.:||.:.:::|.|                         :..|.||:
Human   291 LHGGVS-DITDLELLDKIERSKIVSTMRCKTRQKSEKQMEEKRRANQKSSAQGPIPWFLPESRSL 354

  Fly   294 ----------------------------------------------C------------------ 294
                                                          |
Human   355 PSSPLRLGSYKAQKTSRSSSIPCSGSLDGRELSRQVRSSVELELERCRQQAGLLVTGEKEEPSRS 419

  Fly   295 -----------------------DLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQ 336
                                   |:|||||:...|.:.       |::||...::........||
Human   420 ASEADSEAGELRKPTQEEWRQVVDILWSDPMAQEGCKA-------NTIRGGGCYFGPDVTQQLLQ 477

  Fly   337 NNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 401
            ..|:..:||:||.:..||......:      ::|||||.||.:|.:|:.|.:|....:
Human   478 KYNMQFLIRSHECKPEGYEFCHNRK------VLTIFSASNYYEVGSNRGAYVKLGPAL------- 529

  Fly   402 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEAALRKEVIRN 466
             :||             .:.:...|||..|.....|...:|.......|.|....:.|..|..::
Human   530 -TPH-------------IVQYQANKVTHTLTMRQRISRVEESALRALREKLFAHSSDLLSEFKKH 580

  Fly   467 KIRAIGKMARVFSVLREESESVLQL 491
            ....:|.:  ..|......||||.|
Human   581 DADKVGLI--TLSDWAAAVESVLHL 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pp2B-14D	NP_001245715.1	MPP_PP2B	107..411	CDD:277361	95/441 (22%)
PPEF2	NP_006230.2	MPP_RdgC	122..537	CDD:277364	101/473 (21%)
		Catalytic	128..540		98/470 (21%)
		PP2Ac	141..540	CDD:197547	95/451 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..382		3/63 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..435		0/25 (0%)
		EFh	657..722	CDD:238008
		EF-hand_7	657..721	CDD:290234
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..753

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900