DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pp2B-14D and CanA1

DIOPT Version :9

Sequence 1:	NP_001245715.1	Gene:	Pp2B-14D / 32624	FlyBaseID:	FBgn0011826	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001247378.2	Gene:	CanA1 / 43670	FlyBaseID:	FBgn0010015	Length:	622	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	403/549 - (73%)
Similarity:	465/549 - (84%)	Gaps:	32/549 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SAEATDANSTASNNNNNSSSTAAAGNNSDNSSPTTGTGTGASTGKLHGGHTAVNTKERVVDSVPF 88
            ||.:|.::.|..::.:.|||:..:..:|.|||.:.   |.||..|....:|  .|:||:||.||.
  Fly     2 SATSTRSSVTRKSSLSKSSSSDKSAKSSSNSSKSP---TAASGNKQKMQYT--KTRERMVDDVPL 61

  Fly    89 PPSHKLTLAEVFDQ-RTGKPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQEKTMIDIEAPVT 152
            ||:||||::||:|. :|||||.:.|:|||:||||||||.||:||.:||||||:||.|||:|||:|
  Fly    62 PPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAPIT 126

  Fly   153 VCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNH 217
            |||||||||:||:|||||||.||:|:|||||||||||||||||||||||||||||.||.||||||
  Fly   127 VCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNH 191

  Fly   218 ECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLD 282
            |||||||||||||||.|||||.:|||||:||||||||||:||||||:||||||||..|:||:.|:
  Fly   192 ECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLN 256

  Fly   283 RFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAH 347
            ||:||||:|||||||||||||||||||.::|::||||||||||:||:|||:|||.||||||:|||
  Fly   257 RFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAH 321

  Fly   348 EAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNF 412
            ||||||||||||:|.||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   322 EAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNF 386

  Fly   413 MDVFTWSLPFVGEKVTEMLVNVLNICSDDELMT---EESEEPL-----------SDDE------- 456
            |||||||||||||||||||||:|||||||||:.   :|.||.|           |::.
  Fly   387 MDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANASNNNNNNNTPS 451

  Fly   457 -----AALRKEVIRNKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSLKNAM 516
                 :|||||:|||||||||||:||||:|||||||||||||||||||||:||||||:.|||.|:
  Fly   452 KPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGALSGGRDSLKEAL 516

  Fly   517 QGFSPNHKITSFAEAKGLDAVNERMPPRR 545
            ||.:.:..|.|||||||||||||||||||
  Fly   517 QGLTASSHIHSFAEAKGLDAVNERMPPRR 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2B-14D	NP_001245715.1	MPP_PP2B	107..411	CDD:277361	257/303 (85%)
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	257/303 (85%)
CanA1	NP_001247378.2	PP2Ac	98..369	CDD:197547	229/270 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440204
Domainoid	1	1.000	296	1.000	Domainoid score	I796
eggNOG	1	0.900	-	-		E1_COG0639
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	787	1.000	Inparanoid score	I260
Isobase	1	0.950	-	0.740582	Normalized mean entropy	S271
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	1	1.000	-	-		mtm6407
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	P	PTHR45673
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X576
	12	11.750