DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pp2B-14D and Ppef1

DIOPT Version :9

Sequence 1:	NP_001245715.1	Gene:	Pp2B-14D / 32624	FlyBaseID:	FBgn0011826	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_038955765.1	Gene:	Ppef1 / 317498	RGDID:	1562772	Length:	664	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	118/528 - (22%)
Similarity:	209/528 - (39%)	Gaps:	145/528 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 HTAVNTKER--VVDSVPFPPSH-------KLT------LAEVFDQRTGKPNHELLKQHFILEGRI 122
            :|.:.:|:|  .|..:..|.|:       .||      |.:.|.|:      :.|..|::||
  Rat   111 NTRLESKDREEYVGLIDVPDSYDGPRLQFPLTFTDINLLLQAFKQQ------QTLHAHYVLE--- 166

  Fly   123 EEAPALKIIQDGAALLRQEKTMIDIEA----PVTVCGDIHGQFYDLMKLFEVGGSPA-STKYLFL 182
                   ::.:...:|:|......|:.    .:|:|||:||:..|||.:|...|.|: ...|:|.
  Rat   167 -------VLFEARKILKQMPNFTRIQTFPAKEITICGDLHGKLDDLMLIFYKNGLPSEKNPYVFN 224

  Fly   183 GDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKY---SERVYDAC 244
            ||:||||..|:|.::.|....:.||..|.|.|||||...:...:.|.:|...||   .:::....
  Rat   225 GDFVDRGNNSMEILMILLVSFLVYPTDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGKKILQVL 289

  Fly   245 MDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFK-----EPP------------AFGP 292
            .:.:..||:..:::.:.|.:|||:| |..:|..:::|.|.|     .||            ..||
  Rat   290 EELYTWLPIGTIIDNEILVIHGGIS-ESTDLNILQQLQRNKMKSVLMPPMSTNQECNIKKNKAGP 353

  Fly   293 ----------------MCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLL 341
                            :.|||||||....|...|:.       ||...::........|..|.|.
  Rat   354 SEQSASEQLTKLEWEQIIDLLWSDPRGKKGCYPNTS-------RGGGCYFGPDVTSKVLNKNQLK 411

  Fly   342 SIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLK----------------- 389
            .:||:||.:..||.:....:      :||:|||.||.:..:|:.|.::
  Rat   412 MVIRSHECKPDGYEICHDGK------VITVFSASNYYEEGSNRGAYIRLSYGTSPQFFQYQVTST 470

  Fly   390 ------YEN-NVMN------------------IRQFNCSPH--------PYWLPNFMDVFTWSLP 421
                  |:. |.|.                  |..|....|        ..|..:...:...:||
  Rat   471 SCLNPLYQRVNAMEFSAFRILKERMIARKTDLINAFELRDHSRTGKISLAQWAFSMESILGLNLP 535

  Fly   422 FVGEKVTEMLVNVLNICSDDELMTEES---EEPLSDDEAALRKEVIRNKIRAIGKMARVFSVLRE 483
            :  ..::..||:..:..|.|.:.:.:.   |:|:.|    ::.::|....|....:..:|:::..
  Rat   536 W--RSLSSHLVSTDSSGSVDYMSSFDDIHIEKPMKD----MKSDLIETMYRYRSDLKIIFNIIDT 594

  Fly   484 ESESVLQL 491
            :...::.:
  Rat   595 DQSGLISM 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2B-14D	NP_001245715.1	MPP_PP2B	107..411	CDD:277361	95/394 (24%)
Ppef1	XP_038955765.1	IQ	40..>57	CDD:197470
		MPP_RdgC	140..466	CDD:277364	93/355 (26%)
		PTZ00183	505..647	CDD:185503	15/104 (14%)
		EF-hand_7	582..650	CDD:404394	1/21 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900