Protein Alignment Pp2B-14D and Ppp3cc

DIOPT Version :10

• Sequence 1: NP_523373.2
• Gene: Pp2B-14D / 32624
• FlyBaseID: FBgn0011826
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_001291920.1
• Gene: Ppp3cc / 19057
• MGIID: 107162
• Length: 522
• Species: Mus musculus
• Alignment Length: 516
• Identity: 375/516 - (72%)
• Similarity: 431/516 - (83%)
• Gaps: 32/516 - (6%)

  Fly    77 NTKERVVDSVPFPPSHKLTLAEVFDQRTGKPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQE 141
            :|.|||:.:|||||:.:|||.|||:  .|||..:|||.|.:.|||:||..|||||.||||:|:||
Mouse     9 STTERVIKAVPFPPTRRLTLKEVFE--NGKPKMDLLKNHLVKEGRVEEEVALKIINDGAAILKQE 71

  Fly   142 KTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITY 206
            ||||::|||:|||||:||||:||||||||||||::|:||||||||||||||||||||||||||.:
Mouse    72 KTMIEVEAPITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINH 136

  Fly   207 PQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPE 271
            |:||||||||||||||||||||||||:|||||.||||||..|||||||||:||||||||||:|||
Mouse   137 PKTLFLLRGNHECRHLTEYFTFKQECRIKYSEMVYDACMHTFDCLPLAALLNQQFLCVHGGMSPE 201

  Fly   272 IHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQ 336
            |..|||||:||||.|||||||:|||||||||||:|:||..:.||||:|||||||:||.|.|:|||
Mouse   202 ITCLEDIRKLDRFSEPPAFGPVCDLLWSDPLEDYGSEKTLEHYTHNTVRGCSYFFSYPAVCEFLQ 266

  Fly   337 NNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 401
            ||:||||||||||||||||||||:|.|||||||||||||||||||||||||||||||||||||||
Mouse   267 NNSLLSIIRAHEAQDAGYRMYRKNQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 331

  Fly   402 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDEL-MTEESEEPLSD---DEAALRKE 462
            ||||||||||||||||||||||||||||||||:||||||:|: :|:|.:..:|.   .....|||
Mouse   332 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDEEMNVTDEEDHYISSCPKGATTGRKE 396

  Fly   463 VIRNKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSLKNAMQ---------- 517
            ||:|||||||||||||:|||||||:||.||||||||.||||.||||||:::.|.|
Mouse   397 VIKNKIRAIGKMARVFTVLREESENVLTLKGLTPTGTLPLGVLSGGKQTIETAKQEAAEEREAIR 461

  Fly   518 GFSPNHKITSFAEAKGLDAVNERMPPRRD--------------QPPTPSEDPNQHSQQGGK 564
            ||:..|:|.||.||:|||.:|||||||::              .||.|  ..::.:..|.|
Mouse   462 GFTIAHRIRSFEEARGLDRINERMPPRKEASYHHDAGRMHSHSHPPHP--QASRRTDHGKK 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pp2B-14D	NP_523373.2	MPP_PP2B	107..411	CDD:277361	254/303 (84%)
Ppp3cc	NP_001291920.1	MPP_PP2B	37..341	CDD:277361	254/303 (84%)
		Catalytic. /evidence=ECO:0000305	52..343		248/290 (86%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298	344..366		20/21 (95%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298	394..408		12/13 (92%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	409..416		5/6 (83%)
		Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298	467..489		15/21 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..522		12/42 (29%)