DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pp2B-14D and Ppp3cc

DIOPT Version :9

Sequence 1:NP_001245715.1 Gene:Pp2B-14D / 32624 FlyBaseID:FBgn0011826 Length:570 Species:Drosophila melanogaster
Sequence 2:NP_001291920.1 Gene:Ppp3cc / 19057 MGIID:107162 Length:522 Species:Mus musculus


Alignment Length:516 Identity:375/516 - (72%)
Similarity:431/516 - (83%) Gaps:32/516 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 NTKERVVDSVPFPPSHKLTLAEVFDQRTGKPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQE 141
            :|.|||:.:|||||:.:|||.|||:  .|||..:|||.|.:.|||:||..|||||.||||:|:||
Mouse     9 STTERVIKAVPFPPTRRLTLKEVFE--NGKPKMDLLKNHLVKEGRVEEEVALKIINDGAAILKQE 71

  Fly   142 KTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITY 206
            ||||::|||:|||||:||||:||||||||||||::|:||||||||||||||||||||||||||.:
Mouse    72 KTMIEVEAPITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINH 136

  Fly   207 PQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPE 271
            |:||||||||||||||||||||||||:|||||.||||||..|||||||||:||||||||||:|||
Mouse   137 PKTLFLLRGNHECRHLTEYFTFKQECRIKYSEMVYDACMHTFDCLPLAALLNQQFLCVHGGMSPE 201

  Fly   272 IHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQ 336
            |..|||||:||||.|||||||:|||||||||||:|:||..:.||||:|||||||:||.|.|:|||
Mouse   202 ITCLEDIRKLDRFSEPPAFGPVCDLLWSDPLEDYGSEKTLEHYTHNTVRGCSYFFSYPAVCEFLQ 266

  Fly   337 NNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 401
            ||:||||||||||||||||||||:|.|||||||||||||||||||||||||||||||||||||||
Mouse   267 NNSLLSIIRAHEAQDAGYRMYRKNQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 331

  Fly   402 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDEL-MTEESEEPLSD---DEAALRKE 462
            ||||||||||||||||||||||||||||||||:||||||:|: :|:|.:..:|.   .....|||
Mouse   332 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDEEMNVTDEEDHYISSCPKGATTGRKE 396

  Fly   463 VIRNKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSLKNAMQ---------- 517
            ||:|||||||||||||:|||||||:||.||||||||.||||.||||||:::.|.|          
Mouse   397 VIKNKIRAIGKMARVFTVLREESENVLTLKGLTPTGTLPLGVLSGGKQTIETAKQEAAEEREAIR 461

  Fly   518 GFSPNHKITSFAEAKGLDAVNERMPPRRD--------------QPPTPSEDPNQHSQQGGK 564
            ||:..|:|.||.||:|||.:|||||||::              .||.|  ..::.:..|.|
Mouse   462 GFTIAHRIRSFEEARGLDRINERMPPRKEASYHHDAGRMHSHSHPPHP--QASRRTDHGKK 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pp2B-14DNP_001245715.1 MPP_PP2B 107..411 CDD:277361 254/303 (84%)
Ppp3ccNP_001291920.1 MPP_PP2B 37..341 CDD:277361 254/303 (84%)
Catalytic. /evidence=ECO:0000305 52..343 248/290 (86%)
PP2Ac 54..325 CDD:197547 229/270 (85%)
SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209 303..307 3/3 (100%)
Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298 344..366 20/21 (95%)
Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298 394..408 12/13 (92%)
Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298 409..416 5/6 (83%)
Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298 467..489 15/21 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..522 12/42 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167832384
Domainoid 1 1.000 89 1.000 Domainoid score I7810
eggNOG 1 0.900 - - E1_COG0639
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53795
OrthoDB 1 1.010 - - D194337at33208
OrthoFinder 1 1.000 - - FOG0000983
OrthoInspector 1 1.000 - - mtm8855
orthoMCL 1 0.900 - - OOG6_100566
Panther 1 1.100 - - O PTHR45673
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R954
SonicParanoid 1 1.000 - - X576
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.750

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