DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pp2B-14D and Ppp3ca

DIOPT Version :10

Sequence 1:NP_523373.2 Gene:Pp2B-14D / 32624 FlyBaseID:FBgn0011826 Length:570 Species:Drosophila melanogaster
Sequence 2:NP_032939.1 Gene:Ppp3ca / 19055 MGIID:107164 Length:521 Species:Mus musculus


Alignment Length:494 Identity:396/494 - (80%)
Similarity:438/494 - (88%) Gaps:16/494 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 VNTKERVVDSVPFPPSHKLTLAEVFDQRTGKPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQ 140
            ::|.:|||.:|||||||:||..|||| ..|||..::||.|.:.|||:||:.||:||.:||::|||
Mouse    11 LSTTDRVVKAVPFPPSHRLTAKEVFD-NDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQ 74

  Fly   141 EKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKIT 205
            ||.::||:|||||||||||||:|||||||||||||:|:||||||||||||||||||||||:|||.
Mouse    75 EKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKIL 139

  Fly   206 YPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP 270
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   140 YPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP 204

  Fly   271 EIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFL 335
            ||:.|:|||:|||||||||:|||||:|||||||||||||..:.:|||:||||||||||.|.||||
Mouse   205 EINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCDFL 269

  Fly   336 QNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF 400
            |:||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   270 QHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF 334

  Fly   401 NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEAALRKEVIR 465
            |||||||||||||||||||||||||||||||||||||||||||.:|  |:......||.||||||
Mouse   335 NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSE--EDGFDGATAAARKEVIR 397

  Fly   466 NKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSLKN----------AMQGFS 520
            ||||||||||||||||||||||||.||||||||.||.|.||||||:|::          |::|||
Mouse   398 NKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFS 462

  Fly   521 PNHKITSFAEAKGLDAVNERMPPRRDQPPTPSEDPNQHS 559
            |.||||||.||||||.:|||||||||..|:   |.|.:|
Mouse   463 PQHKITSFEEAKGLDRINERMPPRRDAMPS---DANLNS 498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pp2B-14DNP_523373.2 MPP_PP2B 107..411 CDD:277361 261/303 (86%)
Ppp3caNP_032939.1 MPP_PP2B 41..345 CDD:277361 261/303 (86%)
Catalytic. /evidence=ECO:0000305 56..340 249/283 (88%)
SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209 307..311 3/3 (100%)
Interaction with PxIxIF motif in substrate. /evidence=ECO:0000250|UniProtKB:Q08209 327..336 8/8 (100%)
Calcineurin B binding. /evidence=ECO:0000269|PubMed:26794871 341..369 27/27 (100%)
Calmodulin-binding. /evidence=ECO:0000269|PubMed:26794871 392..406 13/13 (100%)
Autoinhibitory segment. /evidence=ECO:0000269|PubMed:26794871 407..414 6/6 (100%)
Autoinhibitory domain. /evidence=ECO:0000269|PubMed:26794871 465..487 18/21 (86%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..521 16/27 (59%)

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