DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32750 and VNN2

DIOPT Version :9

Sequence 1:	NP_727067.1	Gene:	CG32750 / 326238	FlyBaseID:	FBgn0052750	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_004656.3	Gene:	VNN2 / 8875	HGNCID:	12706	Length:	520	Species:	Homo sapiens

Alignment Length:	531	Identity:	139/531 - (26%)
Similarity:	226/531 - (42%)	Gaps:	86/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 YIAGVVEYRPTFMGGTSEQLLQANLAGYLE---------IMASGNGTTDIIVFPEATLNSVITLT 84
            :||.|.|:.......|...:.|.:....:.         |..:......|||.||..|...
Human    26 FIAAVYEHAVILPNKTETPVSQEDALNLMNENIDILETAIKQAAEQGARIIVTPEDALYGW---- 86

  Fly    85 AVPKFTEQSLCEEQGD-DDPEI-------------APFLRSLACAAREYGTYLVVNVKERVSEQC 135
               |||.:::.....| .||::             .|....|:|.|::...|::.|:.::  :.|
Human    87 ---KFTRETVFPYLEDIPDPQVNWIPCQDPHRFGHTPVQARLSCLAKDNSIYVLANLGDK--KPC 146

  Fly   136 TS-DETCSSRGYSIHNTNVVFDRQGAVISRYRKWNLYLEPSTNRTESPEIATFTTDFNVTFGHFI 199
            .| |.||...||..:|||||::.:|.:::||.|::||.||..|..|.||:.||.|.|. .||.|.
Human   147 NSRDSTCPPNGYFQYNTNVVYNTEGKLVARYHKYHLYSEPQFNVPEKPELVTFNTAFG-RFGIFT 210

  Fly   200 CFDMLFYTPAQDLVEQLGIRHVIVTKMFNSELPFLTASQFQQGWAWANRVNLLASGGSLPQGGIS 264
            |||:.||.|...||:...:..::....:.:.||.|||.:|...||....||||.:........::
Human   211 CFDIFFYDPGVTLVKDFHVDTILFPTAWMNVLPLLTAIEFHSAWAMGMGVNLLVANTHHVSLNMT 275

  Fly   265 GSGIYAGQQGALARLMITDELVGQRKLLLAKVPLDPEEPIATDEILE-PEIMTPVKLKLLQQPEL 328
            ||||||.....:....:..||   .||||::|...|...:|....:. ....|.:|...:|:...
Human   276 GSGIYAPNGPKVYHYDMKTEL---GKLLLSEVDSHPLSSLAYPTAVNWNAYATTIKPFPVQKNTF 337

  Fly   329 KNFTT---WELPMVRGSSVDKRICQEDLCC--EFRVTWTLEDTQPEYN--YRLGVWV---GQRRY 383
            :.|.:   :....:..::.:..:||::|||  .:|:      .|.|.|  |.||.:.   |:||.
Human   338 RGFISRDGFNFTELFENAGNLTVCQKELCCHLSYRM------LQKEENEVYVLGAFTGLHGRRRR 396

  Fly   384 EEEQYSAIRLCGLFACKGASVESCGLVSEEEVHLQDHRVVFTDLQILGEFVRR---PRRLILPST 445
            |..|     :|.|..||..::.:||    ..|.....|  |....:.|.|...   |..|:....
Human   397 EYWQ-----VCTLLKCKTTNLTTCG----RPVETASTR--FEMFSLSGTFGTEYVFPEVLLTEIH 450

  Fly   446 LSSSSFYALQPSQLAWSMEELANVTRIKMELRQPHSQLMTFAIYGNYFDE---YANGGAGRLGTL 507
            ||...|..|:..:|              :........::|.:::|.::.:   |::.|... ..:
Human   451 LSPGKFEVLKDGRL--------------VNKNGSSGPILTVSLFGRWYTKDSLYSSCGTSN-SAI 500

  Fly   508 LFLLITPLIMM 518
            .:|||..|:|:
Human   501 TYLLIFILLMI 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32750	NP_727067.1	biotinidase_like	29..322	CDD:143591	93/317 (29%)
VNN2	NP_004656.3	biotinidase_like	26..329	CDD:143591	92/315 (29%)
VNN2	NP_004656.3	Vanin_C	344..487	CDD:408788	37/173 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157442
Domainoid	1	1.000	106	1.000	Domainoid score	I6567
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4209
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm8613
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.660