DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32750 and Vnn3

DIOPT Version :9

Sequence 1:	NP_727067.1	Gene:	CG32750 / 326238	FlyBaseID:	FBgn0052750	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001102606.1	Gene:	Vnn3 / 498992	RGDID:	1560609	Length:	500	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	135/515 - (26%)
Similarity:	229/515 - (44%)	Gaps:	69/515 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LISFTLVLTDDNSVENKFYIAGVVEYRPTFMGGT------SEQLLQAN-----LAGYLEIMASGN 64
            ::||.|......:::.  :||.|.|:.......|      .|.||..|     |...:::.|...
  Rat    10 VVSFVLFAQAVGAMDT--FIAAVYEHAVILPNKTESPVSNEEALLLINKNIDILENAIKLAARQG 72

  Fly    65 GTTDIIVFPEATLNSVITLTAVPKFTEQSLCEEQGD-DDPEI-------------APFLRSLACA 115
              ..|||.||..:...|       ||.:::.....| .|||:             .|....|:|.
  Rat    73 --AHIIVTPEDGIYGWI-------FTRETIYPYLEDIPDPEVNWIPCRDPKRFGFTPVQERLSCL 128

  Fly   116 AREYGTYLVVNVKERVSEQC-TSDETCSSRGYSIHNTNVVFDRQGAVISRYRKWNLYLEPST--N 177
            |:|...|:|.|:.::  :.| |:|..|...|...:|||||||.:|.:.:||.|:||: ||..  :
  Rat   129 AKENSIYIVANIGDK--KPCNTTDPQCPRDGRYQYNTNVVFDSEGRLTARYHKYNLF-EPEIQFD 190

  Fly   178 RTESPEIATFTTDFNVTFGHFICFDMLFYTPAQDLVEQLGIRHVIVTKMFNSELPFLTASQFQQG 242
            ..:..|:.||.|.|. .||.|.|||:..|.||..:|:...:..|::...:.:.||.|:|..|...
  Rat   191 FPKDSELVTFDTPFG-KFGVFTCFDIFSYDPAVMVVKDSRVDSVLLPTAWYNTLPLLSAVPFHSA 254

  Fly   243 WAWANRVNLLASGGSLPQGGISGSGIYAGQQGALARLMITDELVGQRKLLLAKVPLDPEEPIATD 307
            ||.|..||:||:.....:..::|||||:..   ..|:...|......:|||:::...|.:.....
  Rat   255 WARAMGVNVLAANTHNTRMHMTGSGIYSPD---AVRVYYYDMETENGQLLLSELRSRPRQHGFPA 316

  Fly   308 EILEPEIMTPVKLKLLQQPELKN---FTTWELPMVRGSSVDKRICQEDLCCEFRVTWTLEDTQPE 369
            |:........||....:|.:.:.   |..:....:.||:.:..:||:||||  .:|:.:.:::.:
  Rat   317 EVDWSAYARTVKPFSSEQADFQGTIYFDEFSFTKLMGSAGNYTVCQKDLCC--HLTYKMSESRMD 379

  Fly   370 YNYRLGVWVGQRRYEEEQYSAIRLCGLFACKGASVESCGLVSEEEVHLQDHRVVFTDLQILGEFV 434
            ..|.||.:.|....|.:.|  :::|.|..|:..::.:||    |.|.....:  |.:..:.|.|
  Rat   380 EAYVLGAFDGLHTVEGQYY--LQICTLLKCQTTNLRTCG----EPVGSAFTK--FEEFSLSGTF- 435

  Fly   435 RRPRRLILPSTLSSSSFYALQPSQLAWSMEELANVTRIKMELRQPHSQLMTFAIYGNYFD 494
              ..:.:.|..:.|.|..||:      ...|::...|::.....| ..::..|:||..|:
  Rat   436 --GTKYVFPQIVLSGSQLALE------RYYEVSRDGRLRSRGGAP-LPVLVMALYGRVFE 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32750	NP_727067.1	biotinidase_like	29..322	CDD:143591	93/320 (29%)
Vnn3	NP_001102606.1	biotinidase_like	26..310	CDD:143591	89/299 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351411
Domainoid	1	1.000	87	1.000	Domainoid score	I7801
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm9093
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.660