DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32750 and Btnd

DIOPT Version :9

Sequence 1:	NP_727067.1	Gene:	CG32750 / 326238	FlyBaseID:	FBgn0052750	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_572298.1	Gene:	Btnd / 31552	FlyBaseID:	FBgn0029848	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	191/511 - (37%)
Similarity:	265/511 - (51%)	Gaps:	65/511 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ENKFYIAGVVEY-RPTFMGGTSEQLLQANLAGYLEIMASGNGTTDIIVFPEATLNSVITLTAVPK 88
            |:..|.|.|||: :|.   |.|.:....:.:...:.:....|..|||||||..|||..|.|.||.
  Fly    25 EDPTYTAAVVEHSQPV---GDSPRARTTSASESFQKIIREVGDVDIIVFPEHILNSQATATFVPH 86

  Fly    89 FTEQ-SLCEEQGDDDPEIAPFLRSLACAAREYGTYLVVNVKERVSEQCT----SD--ETCSSRGY 146
            .::. :.|.:   .|.|:  ||..|:|:||....|:|:||.|:  |.|.    ||  ..|.|.|.
  Fly    87 ESQNITPCYQ---TDYEL--FLIELSCSARANHLYVVINVVEK--ELCAHGAGSDTYNPCPSSGV 144

  Fly   147 SIHNTNVVFDRQGAVISRYRKWNLYLEP--STNRTESPEIATFTTDFNVTFGHFICFDMLFYTPA 209
            ...||||||||:|.::|||||.:|:...  ||:...||:|:.|.|||.||||||||||||||.||
  Fly   145 RYFNTNVVFDRRGRIVSRYRKTHLWRHEYVSTSVLRSPDISIFRTDFGVTFGHFICFDMLFYDPA 209

  Fly   210 QDLVEQLGIRHVIVTKMFNSELPFLTASQFQQGWAWANRVNLLASGGSLPQGGISGSGIYAGQQG 274
            ..||::..|..::....:.||||||.|.|.|:|||:.|.||:||:..|.|.|..||||||||:.|
  Fly   210 MKLVKEHKITDIVYPTYWFSELPFLGAVQLQEGWAFGNDVNVLAADASNPDGRTSGSGIYAGRGG 274

  Fly   275 ALARLMITDELVGQ--RKLLLAKVPLDPEEPIAT--DEILEPEIMTPVKLKLLQQPELKNFTTWE 335
            .|..     |:..|  .|||:|:||......:|.  ..|.||:..|. :|..|......|...:|
  Fly   275 RLVA-----EIFEQPTTKLLIAEVPKREHGQLAPTFTPIFEPQRKTQ-RLTGLATYRDNNVDIFE 333

  Fly   336 LPMVRGS--SVDKRICQEDLCCEF----RVTWTLEDTQP-----EYNYRLGVW-------VGQRR 382
            ..::...  |.::::|....||.|    :||...|:..|     .|.||:||:       :|..|
  Fly   334 SELLDDDFLSFERQLCHGSFCCTFSIERKVTSAAENELPSSGAKSYRYRIGVYWGNETTVIGVDR 398

  Fly   383 YEEEQYSAIRLCGLFACKGASVESCGLV-SEEEVHLQDHRVVFTDLQILGEFVRRP--RRLILPS 444
            .|:      ..|.||||....:.|||.: .|.|..:..|.  ||.|.|.|.|...|  ||||:||
  Fly   399 TEQ------ATCALFACTDVRLASCGYIYPENEEVINTHH--FTKLSISGNFPAAPRGRRLIMPS 455

  Fly   445 TLSSSSFYALQPSQLAW--SMEELANVTR---IKMELRQPHSQLMTFAIYGNYFDE 495
            :| ::.|..:..|...|  |.|...|:.:   :.::|.:..:.|:||||:.||:.:
  Fly   456 SL-NALFLPVSVSDYEWIESPEAANNLDKTILVDLKLAKAQNDLLTFAIWANYYTD 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32750	NP_727067.1	biotinidase_like	29..322	CDD:143591	131/306 (43%)
Btnd	NP_572298.1	biotinidase_like	29..308	CDD:143591	126/293 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466617
Domainoid	1	1.000	107	1.000	Domainoid score	I6443
eggNOG	1	0.900	-	-		E1_COG0388
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4181
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		otm26620
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	1	1.100	-	-	P	PTHR10609
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5840
SonicParanoid	1	1.000	-	-		X969
	12	11.830