DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32750 and Btd

DIOPT Version :9

Sequence 1:	NP_727067.1	Gene:	CG32750 / 326238	FlyBaseID:	FBgn0052750	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_006252671.1	Gene:	Btd / 306262	RGDID:	1305316	Length:	535	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	142/526 - (26%)
Similarity:	218/526 - (41%)	Gaps:	94/526 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ENKFYIAGVVEYRPTFMGGTSE--------QLLQANLAGY-LEIMASGNGTTDIIVFPEATLNSV 80
            |.::|:|.|.|:|........|        :|::.||..| .::||:......||||||..::..
  Rat    46 EAEYYVAAVYEHRSVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHGF 110

  Fly    81 -ITLTAVPKFTEQSLCEEQGDDDPEIAPF-------LRSLACAAREYGTYLVVNVKERVSEQCT- 136
             .|.|::..|.:..........:|.:.||       |:.|:|.|.:...:||.|:..:  :.|.
  Rat   111 NFTRTSIYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGTK--QPCLG 173

  Fly   137 SDETCSSRGYSIHNTNVVFDRQGAVISRYRKWNLYLEPSTNRTESPEIATFTTDFNVTFGHFICF 201
            ||..|...|....||||.|...|.::.||||.|||.|.:.:.....::.||.|.|...||.|.||
  Rat   174 SDPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKFGMFTCF 238

  Fly   202 DMLFYTPAQDLVEQLGIRHVIVTKMFNSELPFLTASQFQQGWAWANRVNLLASGGSLPQGGISGS 266
            |:||:.||..|:....::|:.....:.::||.|.|.:.|:.:|.|..|.:||:....|..|::||
  Rat   239 DILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLAANIHHPTLGMTGS 303

  Fly   267 GIYAGQQGALARLMITDELVGQRKLLLAKVPLDPEEPIATDEILEPEIMTPVKLKLL-------- 323
            ||:...:......|  |:..|.  |::|:|..:|:..:.|:.....  |.|...|.|
  Rat   304 GIHTPLKSFWYHNM--DDPEGH--LIIARVATNPQGLVGTENTTSE--MDPSHRKFLKVLSGDPY 362

  Fly   324 -----QQPELKNFTTWELPM-----------------VRGSSVDKRICQEDLCCEFRVTWTLEDT 366
                 |:........|.|..                 |.|.....::|...|||.      |...
  Rat   363 CEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVPVWGKEGHLQVCSNSLCCH------LLFE 421

  Fly   367 QPEYN---YRLGVWVGQRRYEEEQYSAIRLCGLFACKGASVESCGL-VSEEE----VHLQDHRVV 423
            :|..:   |.|||:.|........|  ::.|.|..|.||..|:||. :||.|    .||..:
  Rat   422 RPALSKELYALGVFDGLHTVHGTYY--VQACALVKCGGAGFETCGQEISEAEGLFDFHLWGN--- 481

  Fly   424 FTDLQILGEFVRRPRRLILPSTLSSSSFYALQPSQLAWSMEELANVTRIKMELRQPHSQLMTFAI 488
            |:.|.:.      |..|....||.:       |.||.|..:...      :..|...|.|:|.|:
  Rat   482 FSTLYVF------PLFLTSGMTLDT-------PDQLGWESDHYF------LRKRGLSSGLVTAAL 527

  Fly   489 YGNYFD 494
            ||..::
  Rat   528 YGRLYE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32750	NP_727067.1	biotinidase_like	29..322	CDD:143591	92/310 (30%)
Btd	XP_006252671.1	biotinidase_like	50..353	CDD:143591	92/310 (30%)
Btd	XP_006252671.1	Vanin_C	385..535	CDD:408788	44/179 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351412
Domainoid	1	1.000	87	1.000	Domainoid score	I7801
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm9093
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	1	1.100	-	-	O	PTHR10609
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900