DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubi-p5E and Ubqln3

DIOPT Version :9

Sequence 1:	NP_001284937.1	Gene:	Ubi-p5E / 326237	FlyBaseID:	FBgn0086558	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	XP_017444687.1	Gene:	Ubqln3 / 308905	RGDID:	1304920	Length:	678	Species:	Rattus norvegicus

Alignment Length:	659	Identity:	125/659 - (18%)
Similarity:	206/659 - (31%)	Gaps:	245/659 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKES 65
            :::.|||...|. ...|..:.||..:|.||..:....|:|..||||||.|:|..:|:...::...
  Rat    45 IRVTVKTPKDKE-DFSVVDTCTIRQLKEKISHRFKAHPNQLVLIFAGKILKDPDSLAQCGVRDGL 108

  Fly    66 TLHLVLRLR---------------------------------GGMQIFVKTLTG------KTITL 91
            |:|||::::                                 |.....:..|||      .:.:.
  Rat   109 TVHLVIKMQRRTTGTECPAPPVSTPGPNPLELPQPNSAYPVDGSPSFSLGVLTGLSGLGLTSGSF 173

  Fly    92 EVEPSD------TIENVKAKIQDKEGIP----------------PDQQRLIFAGKQLEDGRTLSD 134
            ..:|..      ::..:.|::.|...|.                |..|:||....::  |..|::
  Rat   174 SDQPGSLMWQHMSVPELVAQLVDDPFIQGLLSNTGLMRQLVLDNPHMQQLIQQNPEI--GHILNN 236

  Fly   135 YNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDK-----EGIPPDQQR 194
            ..|.::                         |:|...:.::.....:.||:     |.||.....
  Rat   237 PEIMRQ-------------------------TMEFLRNPSMMQEMMRSQDRALSNLESIPGGYNV 276

  Fly   195 LIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIEN------ 253
            |          ||:  |....:..|:.|....|| ..|....|..|.|...:||.| ||
  Rat   277 L----------RTM--YTDIMDPMLNAVQEQFGG-NPFATATTASTTTTSSQPSRT-ENCDPLPN 327

  Fly   254 -------VKAKIQDKEGIPPDQ------QRL-IFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 304
                   |....|.::  |.||      .|| .|.|     ...|.||..|    ||...:..|.
  Rat   328 PWTSTCGVSGSRQGRQ--PGDQDTSESRNRLPSFLG-----NIGLFDYLQQ----LHETSQALGS 381

  Fly   305 -MQIFVKT--------LTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDG--R 358
             :|..|.|        |:|..:...:.||.         :...|.|..:..:...||.....  |
  Rat   382 YLQGTVPTPSSSQETPLSGNRVPPNLPPSP---------KPGSGQPLPKDSVAIKGKSSCPAFLR 437

  Fly   359 TLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEG-------- 415
            ..|:.:..:..:||               .:||:.|   .||..:.|:.::|.|...
  Rat   438 HSSENSTGQGGSLH---------------DSGKSST---GPSTGLPNLTSQIGDNANRSPFVSTP 484

  Fly   416 ---------------IPP-DQQRLIFAGKQLEDGRTLSDYNIQKESTLHL------------VLR 452
                           :|| ...|.:.:....:..|..::.:.|....|||            :|:
  Rat   485 SSLISPTPGAPESPWLPPTGYPRSLRSALTNQVPRMQNELHQQLPLLLHLQTAMTNPRVMQALLQ 549

  Fly   453 LRGGMQI-----------FVKTLTGKTITLEVEPSDTIENVKAKIQDKEGI---------PPDQQ 497
            :..|:||           |:..|.|            :..|....:.:||:         |..|.
  Rat   550 IEQGLQILATEAPRLLLWFMPCLAG------------LSGVIGGTESREGVVMSEDPRPTPTSQI 602

  Fly   498 RLIFAGKQL 506
            .|:....:|
  Rat   603 SLVQGSAEL 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubi-p5E	NP_001284937.1	Ubiquitin	1..76	CDD:176398	25/107 (23%)
		UBQ	1..72	CDD:214563	25/70 (36%)
		Ubiquitin	77..152	CDD:176398	14/102 (14%)
		UBQ	77..148	CDD:214563	14/98 (14%)
		Ubiquitin	153..228	CDD:176398	13/79 (16%)
		UBQ	153..224	CDD:214563	13/75 (17%)
		Ubiquitin	229..304	CDD:176398	24/94 (26%)
		UBQ	229..300	CDD:214563	24/90 (27%)
		Ubiquitin	305..380	CDD:176398	15/84 (18%)
		UBQ	305..376	CDD:214563	15/80 (19%)
		Ubiquitin	381..456	CDD:176398	17/110 (15%)
		UBQ	381..452	CDD:214563	16/106 (15%)
		Ubiquitin	457..532	CDD:176398	12/70 (17%)
		UBQ	457..528	CDD:214563	12/70 (17%)
Ubqln3	XP_017444687.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900