DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubi-p5E and UBD

DIOPT Version :9

Sequence 1:	NP_001284937.1	Gene:	Ubi-p5E / 326237	FlyBaseID:	FBgn0086558	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_006389.2	Gene:	UBD / 10537	HGNCID:	18795	Length:	165	Species:	Homo sapiens

Alignment Length:	156	Identity:	50/156 - (32%)
Similarity:	83/156 - (53%)	Gaps:	6/156 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTL 67
            :.|::.....:|.:..|.|:::.:|..::.|..:|...|.|:...|.|:..|:||.|.|.||.|:
Human    10 VHVRSEEWDLMTFDANPYDSVKKIKEHVRSKTKVPVQDQVLLLGSKILKPRRSLSSYGIDKEKTI 74

  Fly    68 HLVLRL----RGGMQIFVKTL--TGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQL 126
            ||.|::    ...:.:|:...  ..|...|:|..|.::..|||.|:.|.||.|:.|.:...||:|
Human    75 HLTLKVVKPSDEELPLFLVESGDEAKRHLLQVRRSSSVAQVKAMIETKTGIIPETQIVTCNGKRL 139

  Fly   127 EDGRTLSDYNIQKESTLHLVLRLRGG 152
            |||:.::||.|:|.:.|.|.....||
Human   140 EDGKMMADYGIRKGNLLFLACYCIGG 165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubi-p5E	NP_001284937.1	Ubiquitin	1..76	CDD:176398	22/76 (29%)
		UBQ	1..72	CDD:214563	21/68 (31%)
		Ubiquitin	77..152	CDD:176398	26/76 (34%)
		UBQ	77..148	CDD:214563	26/72 (36%)
		Ubiquitin	153..228	CDD:176398	50/156 (32%)
		UBQ	153..224	CDD:214563	50/156 (32%)
		Ubiquitin	229..304	CDD:176398
		UBQ	229..300	CDD:214563
		Ubiquitin	305..380	CDD:176398
		UBQ	305..376	CDD:214563
		Ubiquitin	381..456	CDD:176398
		UBQ	381..452	CDD:214563
		Ubiquitin	457..532	CDD:176398
		UBQ	457..528	CDD:214563
UBD	NP_006389.2	UBQ	8..79	CDD:214563	21/68 (31%)
UBD	NP_006389.2	UBQ	104..165	CDD:320785	24/60 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810