DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn and NRP1

DIOPT Version :10

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:XP_006717584.1 Gene:NRP1 / 8829 HGNCID:8004 Length:924 Species:Homo sapiens


Alignment Length:936 Identity:212/936 - (22%)
Similarity:328/936 - (35%) Gaps:281/936 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   975 NDKCGG-VHTRSGDHIRLPVHDDSYAGEATCYWVIMAP-ANKAIRLHWN-SFSLENAVDCIYDYL 1036
            |||||. :...|..::..|.:..||.....|.|:|.|| ..:.|.:::| .|.||:. ||.|||:
Human    24 NDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR-DCKYDYV 87

  Fly  1037 EIYDSLGAQVNDERSKPLAKYCGNSVPEDLLSHSRQLVLKFVSDYSESDGGFDLTY-TFEDRAKC 1100
            |::|.     .:|......|:||...|..::|....|.:||||||.....||.:.| .|:...:|
Human    88 EVFDG-----ENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPEC 147

  Fly  1101 GGHIHASSGELTSPEYPANYSAGLDCDWHLTGTIDHLLEI--QVENFELEQSPN------CSADY 1157
            ..:....||.:.||.:|..|...|:|.:.:  .:..:.||  :.|:|:||...|      |..|.
Human   148 SQNYTTPSGVIKSPGFPEKYPNSLECTYIV--FVPKMSEIILEFESFDLEPDSNPPGGMFCRYDR 210

  Fly  1158 LEVRNGGGTDSPLIGRFCGRDIPARIPGFSHEMRLILHTDSAINGRGFRLRWRIFA------FGC 1216
            ||:.:|.....|.|||:||:..|.||...|..:.::.:|||||...||...:.:..      |.|
Human   211 LEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKC 275

  Fly  1217 GGSLRSNMGAI---------------SSPRYPNSYPNM-------AHCEW-RISLHPGSGISLLI 1258
            ..:|....|.|               |:.|...:||..       ::.|| ::.|    |:...:
Human   276 MEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDL----GLLRFV 336

  Fly  1259 EDLELEG-----LSNCYY-------------DSVKIYTGIKLP-----NQSPCKVL--------- 1291
            ..:..:|     ....||             |.:.|..|.| |     |.:|..|:         
Human   337 TAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNK-PVLFQGNTNPTDVVVAVFPKPLI 400

  Fly  1292 -----------------------CKDDDLHNPLIQLENNKGTIVFDSDASNTFRGFRISYKANCI 1333
                                   ||..|.  |...:......::.||..:::.:|.| ::....|
Human   401 TRFVRIKPATWETGISMRFEVYGCKITDY--PCSGMLGMVSGLISDSQITSSNQGDR-NWMPENI 462

  Fly  1334 RNLTATTGTIESLNYMEPFWETIP-----INCSWTIRAPKGNRVLVEVSHLARHEQHVPTATMPG 1393
            |.:|:.:|           |...|     || .| ::...|...:|.                  
Human   463 RLVTSRSG-----------WALPPAPHSYIN-EW-LQIDLGEEKIVR------------------ 496

  Fly  1394 GLYIVDGRNVQEIVTPQAMNI----SGEVLTVVHNASN---VNFQLDYRIDGCMEELRGTFGFFQ 1451
            |:.|..|::.:..|..:...|    :|....::.:.|.   .:|:.:...|  ..||| ||... 
Human   497 GIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYD--TPELR-TFPAL- 557

  Fly  1452 SPNYPKMYPNNLECYWLITVEQDSAIELTINNIDLEDSPNCTKDALTVSNHKNSVEVHERHCGST 1516
            |..:.::||.                             ..|...|.:.......||.....|.|
Human   558 STRFIRIYPE-----------------------------RATHGGLGLRMELLGCEVEAPTAGPT 593

  Fly  1517 T---KLVITSSGHRLHVRFISDNSHNGLG--FEAT-YRTVKATCGGKLTARNGVIES--PNYPLN 1573
            |   .||......:.       |.|:|.|  |:.| ..||.||  .|.|..:..|:|  |.|..|
Human   594 TPNGNLVDECDDDQA-------NCHSGTGDDFQLTGGTTVLAT--EKPTVIDSTIQSEFPTYGFN 649

  Fly  1574 ----YPAHSR-CEWQVEVSQHHQIVFEMADLNLESGYDCNWDYLEA-YDLTEDDTEGERLFKVC- 1631
                :.:|.. |.|  |...|.|:               .|..|.: ....:|.|.|:..|... 
Human   650 CEFGWGSHKTFCHW--EHDNHVQL---------------KWSVLTSKTGPIQDHTAGDGNFIYSQ 697

  Fly  1632 GDETEDDKLLSSSSNMAVVRFI-----SDDSVSKKGFRLHFHESCGQTIIVD---ETMFDYIQMS 1688
            .||.:..|         |.|.:     |.:|.....|..|...|...|:.|.   :...:|.|:.
Human   698 ADENQKGK---------VARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLV 753

  Fly  1689 RQAARNESCLWVFQAVEPNK-----RIIF------------------TPTHVKLREDANQQYPTE 1730
            ..|..::...|....|..:|     ::||                  ...|:. :||..:  |.:
Human   754 WMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHIS-QEDCAK--PAD 815

  Fly  1731 GDCLNVGVKI--------YEGTEPQG 1748
            .|..|..:||        ||| |.:|
Human   816 LDKKNPEIKIDETGSTPGYEG-EGEG 840

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 cubilin_NTD 21..149 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_CA 324..367 CDD:214542
EGF 430..457 CDD:394967
EGF_CA 469..503 CDD:238011
CUB 509..622 CDD:238001
CUB 627..737 CDD:238001
CUB 744..849 CDD:412131
CUB 853..970 CDD:238001
CUB 978..1094 CDD:238001 39/119 (33%)
CUB 1100..1211 CDD:238001 38/118 (32%)
CUB 1216..1330 CDD:238001 31/191 (16%)
CUB 1446..1549 CDD:238001 20/108 (19%)
CUB 1554..1667 CDD:238001 27/126 (21%)
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:412131
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:412131
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:412131
CUB 3623..3733 CDD:238001
NRP1XP_006717584.1 CUB 27..140 CDD:238001 39/118 (33%)
CUB 147..264 CDD:238001 38/118 (32%)
FA58C 277..423 CDD:238014 22/150 (15%)
FA58C 435..582 CDD:238014 34/211 (16%)
MAM 650..811 CDD:459878 35/187 (19%)
DUF3481 846..924 CDD:403259
Blue background indicates that the domain is not in the aligned region.

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