DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cubn and Cubn

DIOPT Version :9

Sequence 1:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster
Sequence 2:	NP_445784.3	Gene:	Cubn / 80848	RGDID:	68355	Length:	3623	Species:	Rattus norvegicus

Alignment Length:	3909	Identity:	1156/3909 - (29%)
Similarity:	1761/3909 - (45%)	Gaps:	556/3909 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VNSPKIISKDGNLIFESGANRNISFRLSGNSRLTINEELDVMELLLATSGSKKRSGGKDDDFVDA 94
            ::.|::.:::|||:|.:.:.:||.||.....::.:|:| |:.|.|.....:|       ||.:|.
  Rat    36 LHQPRMTTEEGNLVFLTSSTQNIEFRTGSLGKIKLNDE-DLGECLHQIQRNK-------DDIIDL 92

  Fly    95 RELADQLADFNRRAFGANGLSAMLRVQQNRTRGSMALLRRFQTRLRALENRVDRMKTDLEANSCA 159
            |:        |......|.||.               :.:..::|..||.....::.::|...|:
  Rat    93 RK--------NTTGLPQNILSQ---------------VHQLNSKLVDLERDFQNLQQNVERKVCS 134

  Fly   160 SGPCENGGTCYNTYTGFRCQCRSAFEGTKCEMDVNECALYEGTDLGCQNGGQCQNHFGTYSCLCQ 224
            |.||.|||||.|.:..|.|.|.|.::|..|..|||||.:|.||..|||:|..|.|..|::.|.|.
  Rat   135 SNPCLNGGTCVNLHDSFVCICPSQWKGLFCSEDVNECVVYSGTPFGCQSGSTCVNTVGSFRCDCT 199

  Fly   225 PGWHGMHCTQRKADCSQSSAWELCGHGSCVPSADD--------AGYRCICEPGWKT--NGLTPIC 279
            |..:|..|..:..||.|.|. :||.||.|    :|        ..:.|||:.||.|  ||::  |
  Rat   200 PDTYGPQCASKYNDCEQGSK-QLCKHGIC----EDLQRVHHGQPNFHCICDAGWTTPPNGIS--C 257

  Fly   280 GEDVDECSDSAAHKPCS--TSCINLPGSFTCAPCPAGLTGNGVSCRDLDECQTNNGGCSLSPKVD 342
            .||.|||  |....|||  ..|.|..|||.|..||.|..|||..|:|::||:.||||||.:|.|.
  Rat   258 TEDKDEC--SLQPSPCSEHAQCFNTQGSFYCGACPKGWQGNGYECQDINECEINNGGCSQAPLVP 320

  Fly   343 CINTYGSYHCGECPVGWTGDGRKCERSPQDIDIPAGQTPRTCPAGNNPCYPTASC----FLISGT 403
            |:||.||:.||.||.|::||||.|  :|.||          |...|..|:|.|:|    .|.|..
  Rat   321 CLNTPGSFSCGNCPAGFSGDGRVC--TPVDI----------CSIHNGGCHPEATCSSSPVLGSFL 373

  Fly   404 TSCRCPMGMVGTGYGPNGCVNGTTTNCKENPCLNGGICLFAGPSNYTCLCPIGFRPPICEPQPSP 468
            ..|.||.|..|.|||.||||. .:..|..:||:||. |: ...|:|.|.|..|:....|....:.
  Rat   374 PVCTCPPGYTGNGYGSNGCVR-LSNICSRHPCVNGQ-CI-ETVSSYFCKCDSGWSGQNCTENIND 435

  Fly   469 CDQHPCKNGGRCRPTTSGDLFVCQCLPGYRGRLCETRFSSCNGMLSAQSGRLRYPPEGTGYEHNA 533
            |..:||.|||.|....:|  |.|.|...:.|..|:|..::|.|:||...|...|......|.||.
  Rat   436 CSSNPCLNGGTCIDGING--FTCDCTSSWTGYYCQTPQAACGGILSGTQGTFAYHSPNDTYIHNV 498

  Fly   534 QCAWVIRTNESLVVNVTFNSFDVEDSTECRFDWLQINDGRSAAAQIIGRYCGNHLPHGGNIVSSG 598
            .|.|::||:|..|::|||..||:|.::.|..::|||:||.|:|...:|||||:..|.|  |.||.
  Rat   499 NCFWIVRTDEEKVLHVTFTFFDLESASNCPREYLQIHDGDSSADFPLGRYCGSRPPQG--IHSSA 561

  Fly   599 NQLYLWFRSDNSTAKEGFDLTWNSMEPQCGGRLNFETHGTLASPGSPGNYPKNRDCRWQLVAPTT 663
            |.||....|:...:..||...|.:..|:|||.|. :.:|::.|||.|||||..|||.||::....
  Rat   562 NALYFHLYSEYIRSGRGFTARWEAKLPECGGILT-DNYGSITSPGYPGNYPPGRDCVWQVLVNPN 625

  Fly   664 KRIKLTFFSLQLEQHANCNFDYVLIKDSISGRE--LAKYCTTGAPAPLLLPTHLAEIHFHSDAEG 726
            ..|..||.:|.||.|.:|:.||:.|:|....::  |.|:||:.:..||......|.||||||:|.
  Rat   626 SLITFTFGTLSLESHNDCSKDYLEIRDGPFHQDPVLGKFCTSLSTPPLKTTGPAARIHFHSDSET 690

  Fly   727 SDTGFQLHYSVEERVPGCGGVYTAKEGTISESSTANTEPGGVSCEYEIHLAVGEQVVIQFARLEL 791
            ||.||.:.|...:....|||.||..:|.:.....:........|.|.|..|.|||:||.|..:||
  Rat   691 SDKGFHITYLTTQSDLDCGGNYTDTDGELLLPPLSGPFSHSRQCVYLITQAQGEQIVINFTHVEL 755

  Fly   792 D-PLDCLEVLDITDEGGSILQEKICGSDASRLNPPTFTSE--FNRLKIKFYARAGSFQLNYRMAC 853
            : .:.|........:..|:|: ||||::.  |.|....|.  :.||:|....:..||:.:|::||
  Rat   756 ESQMGCSHTYIEVGDHDSLLR-KICGNET--LFPIRSVSNKVWIRLRIDALVQKASFRADYQVAC 817

  Fly   854 DYKLNNEQGTITSPGYPNLTRSDRICTYTISTATNTVISLKRIDFQLTNGESDDDDNDECLTTNL 918
            ...|..| |...||.|||.....|.|.:|||.....|:.|...|||:.:..|.|.|..|...:::
  Rat   818 GGMLRGE-GFFRSPFYPNAYPGRRTCRWTISQPQRQVVLLNFTDFQIGSSASCDTDYIEIGPSSV 881

  Fly   919 RINDGLNRKILGPYCGKNQPEENFVSET-NYLQLHLSTDVDSMGRGFKFEYRALATGNDK--CGG 980
            ..:.| |.|    :|..|.|  :|::.. |.|.:..........|||..::     .:||  ||.
  Rat   882 LGSPG-NEK----FCSSNIP--SFITSVYNILYVTFVKSSSMENRGFTAKF-----SSDKLECGE 934

  Fly   981 VHTRSGDHIRLPVHDDSYAGEATCYWVIMAPANKAIRLHWNSFSLENAVDCIYDYLEIYDSLGAQ 1045
            |.|.|...|..|.|.:.|.....|.|.::....:.|||.::||.||...:|..|||||||: .||
  Rat   935 VLTASTGIIESPGHPNVYPRGVNCTWHVVVQRGQLIRLEFSSFYLEFHYNCTNDYLEIYDT-AAQ 998

  Fly  1046 VNDERSKPLAKYCGNSVPEDLLSHSRQLVLKFVSDYSESDGGFDLTYTFEDRAK-CGGHIHASSG 1109
            ..      |.:|||.|:|..|.|:|..:.|.||||.:.:..||.:.|...|.:. |......:.|
  Rat   999 TF------LGRYCGKSIPPSLTSNSNSIKLIFVSDSALAHEGFSINYEAIDASSVCLYDYTDNFG 1057

  Fly  1110 ELTSPEYPANYSAGLDCDWHLTGTIDHLLEIQVENFELEQ--SPNCSADYLEVRNGGGTDSPLIG 1172
            .|:||.:|.||.:..:|.:.:|..::..:.:...:|.||.  ...| .|::|:|:||...|||:|
  Rat  1058 MLSSPNFPNNYPSNWECIYRITVGLNQQIALHFTDFILEDYFGSQC-VDFVEIRDGGYETSPLVG 1121

  Fly  1173 RFCGRDIPARIPGFSHEMRLILHTDSAINGRGFRLRWRIFAFGCGGSLRSNMGAISSPRYPNSYP 1237
            .:||..:|..|...|:::.|...:|:|:..:||...|...:.||||:|.:..|.::||.||..|.
  Rat  1122 IYCGSVLPPTIISHSNKLWLKFKSDAALTAKGFSAYWDGSSTGCGGNLTTPTGVLTSPNYPMPYY 1186

  Fly  1238 NMAHCEWRISLHPGSGISLLIEDLELEGLSNCYYDSVKIYTGIKLPNQSPCKVLCKDDDLHNPLI 1302
            :.:.|.||:....||...|..:|..||...:|..|.:.::.| ...|......||.|.   .| .
  Rat  1187 HSSECYWRLEASHGSPFELEFQDFHLEHHPSCSLDYLAVFDG-PTTNSRLIDKLCGDT---TP-A 1246

  Fly  1303 QLENNKGTIVFD--SDASNTFRGFRISYKANC--IRNLTATTGTIESLNYMEPFWETIPINCSWT 1363
            .:.:||..::..  :||....|||.|:::..|  :..:..|:|.:||:||..|:.:.  ..|:||
  Rat  1247 PIRSNKDVVLLKLRTDAGQQGRGFEINFRQRCDNVVIVNKTSGILESINYPNPYDKN--QRCNWT 1309

  Fly  1364 IRAPKGNRVL-------VEVSHLARHEQHVPTATMPGGLYIVDGRNVQEIVTPQAMNISGEVLTV 1421
            |:|..||.|.       || |::.....:|.....|..:....|.|:     |.....:|..|.|
  Rat  1310 IQATTGNTVNYTFLGFDVE-SYMNCSTDYVELYDGPQWMGRYCGNNM-----PPPGATTGSQLHV 1368

  Fly  1422 VHNASNVN-----FQLDYRIDGCMEELRGTFGFFQSPNYPKMYPNNLECYWLITVEQDSAIELTI 1481
            :.:...:|     |::.:...||..|:.||.|.|.||.||..||:|.||.|.|.|...|:|:|||
  Rat  1369 LFHTDGINSGEKGFKMQWFTHGCGGEMSGTAGSFSSPGYPNSYPHNKECIWNIRVAPGSSIQLTI 1433

  Fly  1482 NNIDLEDSPNCTKDALTV--SNHKNSVEVHERHCG---STTKLVITSSGHRLHVRFISDNSHNGL 1541
            ::.|:|...:|..|:|.:  ....||..:.:. |.   |...:.::|:|:.|.:||.:|::.||.
  Rat  1434 HDFDVEYHTSCNYDSLEIYAGLDFNSPRIAQL-CSQSPSANPMQVSSTGNELAIRFKTDSTLNGR 1497

  Fly  1542 GFEATYRTVKATCGGKLTARNGVIESPNYPLNYPAHSRCEWQVEVSQHHQIVFEMADLNLESGYD 1606
            ||.|::|.|...|||.:....|.|.|||||.||.|::.|.|.::|.:||:::..:.|.:||:...
  Rat  1498 GFNASWRAVPGGCGGIIQLSRGEIHSPNYPNNYRANTECSWIIQVERHHRVLLNITDFDLEAPDS 1562

  Fly  1607 CNWDYLEAYDLTEDDTEGERLFKVCGDETEDDKLLSSSSNMAVVRFISDDSVSKKGFRLHFHESC 1671
            |    |..||  ...:...|:..|||.:...:.:: :|.|...|||.|..|...:|||..|.|.|
  Rat  1563 C----LTTYD--GSSSTNARVASVCGRQQPPNSII-ASGNSLFVRFRSGSSSQNRGFRAEFREEC 1620

  Fly  1672 GQTIIVD--ETMF------DYIQMSRQAARNESCLWVFQAVEPNKRIIFTPTHVKLREDANQQYP 1728
            |..|:.|  :|:|      :|:       .|::|.|:.:|..|...|..:.||.:|:...
  Rat  1621 GGRIMTDSSDTIFSPLYPHNYL-------HNQNCSWIIEAQPPFNHITLSFTHFQLQNST----- 1673

  Fly  1729 TEGDCLNVGVKIYEGTEPQGTPRLKFCR-SHPPALISNGQALTVSVPLQLVEEFQGH---YMTMD 1789
               ||....|:|.:|.:.....:.::|. |.|..:||.|.||||.........|:|.   |....
  Rat  1674 ---DCTRDFVEILDGNDYDAPVQGRYCGFSLPHPIISFGNALTVRFVTDSTRSFEGFRAIYSAST 1735

  Fly  1790 TSCGSIYNALSGKFTSPYYPASYPPNIECLWLLEASMGNSLSLTLESMDLEKSESCNRDYLEVRE 1854
            :|||..:..|.|.|.||.|||.|.||.||:|.:.:|.||.|.|:..|.:||.|.:||:|::|:||
  Rat  1736 SSCGGSFYTLDGIFNSPDYPADYHPNAECVWNIASSPGNRLQLSFLSFNLENSLNCNKDFVEIRE 1800

  Fly  1855 ESESGQLIGVYCGNEVPGVIHSR--GAIWMKFKSDDDNVGEGFMASY-NYEHHNELNGTEGTIES 1916
            .:.:|.|||.||||.:||...|.  .::|::|.||....|.||.|.: |...:|.:.||.|.|.|
  Rat  1801 GNATGHLIGRYCGNSLPGNYSSAEGHSLWVRFVSDGSGTGMGFQARFKNIFGNNNIVGTHGKIAS 1865

  Fly  1917 PHFPSKFQDPVPYSWRITVDKEYVVAISLLYLRDLD------QPHLNFYDGYSDIGARIEVT--- 1972
            |.:|.|:.....|.|.:.||..:::...:|.: |::      ...|..|||: |..:|:..|
  Rat  1866 PFWPGKYPYNSNYKWVVNVDAYHIIHGRILEM-DIEPTTNCFYDSLKIYDGF-DTHSRLIGTYCG 1928

  Fly  1973 DPDETIISSTNVVYF-------TSNRGPFKLNWNRLSKEALRSNRTAEERTRQCGNQLITIDRSV 2030
            ...|:..||.|.:.|       .|.|| |.|.|..:.   :..:.........||..::|.|..|
  Rat  1929 TQTESFSSSRNSLTFQFSSDSSVSGRG-FLLEWFAVD---VSDSTPPTIAPGACGGFMVTGDTPV 1989

  Fly  2031 IGFHSPGYPNGYEQDLNCFWTLVPSNPAMHAVLTLSQIDLEIFSEDCIADYVKIFSG-SDLQNWS 2094
            ..| |||:|..|....:|.|.:..  |.....|.:..:|:|. .:.|..|.:.:..| |||.  .
  Rat  1990 HIF-SPGWPREYANGADCIWIIYA--PDSTVELNILSLDIEP-QQSCNYDKLIVKDGDSDLS--P 2048

  Fly  2095 ELRTLCSL----PTESSDRVFHGRPYLRVEFVTDPSVNKTGFNGIVRTACGSEITASKGLVNITE 2155
            ||..||.:    |..|:..      |:.:.|.:|.||..||||.....:||..:.|.:|::
  Rat  2049 ELAVLCGVSPPGPIRSTGE------YMYIRFTSDTSVAGTGFNASFHKSCGGYLHADRGVI---- 2103

  Fly  2156 ILKVLPR------PNHDCVWTIKVRQGRRIKIDFPD-FQLQNNMASGSSDCR--NYLLLRNGNDE 2211
               ..|:      ||.:|.|.:.|:.|..|.:.|.. ||:||.    .|.|.  :||:||||.|.
  Rat  2104 ---TSPKYPDTYLPNLNCSWHVLVQTGLTIAVHFEQPFQIQNR----DSFCSQGDYLVLRNGPDN 2161

  Fly  2212 DSPFLG----RGKYCEDVVHEVLNTSSNKAYIKFHFASPPRFLVS----------FRFEELRYTD 2262
            .||.||    .|::|.......|.||.|:.:::|         :|          .|:|......
  Rat  2162 HSPPLGPSGRNGRFCGMYAPSTLFTSGNEMFVQF---------ISDSSNGGQGFKIRYEAKSLAC 2217

  Fly  2263 SGRIRLSASGDEQFISSPYYPHLPHPHSECIWIVEAPPEHRIMLHFQGAFDMLDATGEPEECQRE 2327
            .|.:.:..:..:.:::||.||.....|:|||||:||||...|.|.|:..|::.|.    ..|...
  Rat  2218 GGTVYIHDADSDGYLTSPNYPANYPQHAECIWILEAPPGRSIQLQFEDQFNIEDT----PNCSVS 2278

  Fly  2328 FVLINDGSTELRPEIGRYCGNRKPDTIYSTGNQMRIRYFTDVSEPHMGFNASLSVARCGGSFHSP 2392
            ::.:.||:......:.:.||:..|.:..|:..::.:::.||....:|||.|..|:|.|||:....
  Rat  2279 YLELRDGANSNARLVSKLCGHTLPHSWVSSRERIYLKFHTDGGSSYMGFKAKYSIASCGGTVSGD 2343

  Fly  2393 EGVIAS---------------------PSRDLLLIHEEGKQLQECVYTIELEKGSTIDLTSEYLQ 2436
            .|||.|                     |...|.|..|:        :.::...|.|.|....:
  Rat  2344 SGVIESIGYPTLPYANNVFCQWFIRGLPGHYLTLSFED--------FNLQSSPGCTKDFVEIW-- 2398

  Fly  2437 IPTLRNGSCSQRNHLMLEEMDAFGLDGEEKIVDTLMLCGMEAKHLISETNKIVFRYRFLDGIPAE 2501
                       .||.....:..:              ||......: :|:..|...:|:......
  Rat  2399 -----------ENHTSGRVLGRY--------------CGNSTPSSV-DTSSNVASVKFVTDGSVT 2437

  Fly  2502 NQGFRLKYTSLGSRCGETIYASVGVLQTPGYPLGVPHPMHCKWQVQVPKGRRVRLEILDFNTGTN 2566
            ..||||::.|....||..::...|...:|.||...||...|:|.:.|.:|||:.|...:....|.
  Rat  2438 ASGFRLQFKSSRQVCGGDLHGPTGTFTSPNYPNPNPHARICEWTITVQEGRRIVLTFTNLRLSTQ 2502

  Fly  2567 MDLRGRLGFRGRLTVANDFK-----MQSILGRYNVDPPAEVLSSDNTMGIDAFLLPIVQNHGIKL 2626
            ......     .|.|.|..:     :|.:..|.||  ..|..||.|||               |:
  Rat  2503 PSCNSE-----HLIVFNGIRSNSPLLQKLCSRVNV--TNEFKSSGNTM---------------KV 2545

  Fly  2627 RFSAYGSSSCPGFTVMMNEVADIQFQRF-------NISRP-----------LHCSYKVVPPS--N 2671
            .|...||....|||.......|.....|       |.|.|           |.|.:.:..|:  |
  Rat  2546 VFFTDGSRPYGGFTASYTSTEDAVCGGFLPSVSGGNFSSPGYNGIRDYARNLDCEWTLSNPNREN 2610

  Fly  2672 STLLIRVKEYNTTSVMMWNTHMCALLSPLKFNRLEQEEELMERILCDYQSP-APGKPLPSIRLPF 2735
            |::.|...|.:..|      |.......|:|...:.:..|:|: .|...:| ||      :.:|:
  Rat  2611 SSISIYFLELSIES------HQDCTFDVLEFRVGDADGPLIEK-FCSLSAPTAP------LVIPY 2662

  Fly  2736 P-IQLVVSASARNAMTNLVLSYSTQSCGGVIILEPGDNMTVHQPSGMVSAAGAIDCAWAI-GPYT 2798
            | :.:...::.|...|...:.||...|||:   ..|||..:..|:.....:....|:|.: .|
  Rat  2663 PQVWIHFVSNERVEYTGFYIEYSFTDCGGI---RTGDNGVISSPNYPNLYSAWTHCSWLLKAP-- 2722

  Fly  2799 DASGEDEVLVPQDIQLEVSVYNVNLPAPSPSAQSPEAPCLHHYLKVYNGPDQNSPSLGLFCNQA- 2862
              .|....|...|..||.                 ...|....:.|.||....||.:|.:|.|:
  Rat  2723 --EGHTITLTFSDFLLEA-----------------HPTCTSDSVTVRNGDSPGSPVIGRYCGQSV 2768

  Fly  2863 -----TAVNMVV----------ERGLFLEYHSDSFSANATFNVSIKYGSGCGGKLVYPYRAIDFA 2912
                 :..|.::          .||.:..:::::.....||:       ...|.:..|:    :.
  Rat  2769 PRPIQSGSNQLIVTFNTNNQGQTRGFYATWNTNALGCGGTFH-------SANGTIKSPH----WP 2822

  Fly  2913 EQYKNNVECIWEVEATMGYHIGLTFQGRFYIEDSPG-CTKDYLLVQQRNETTGNWTDLQRICGRV 2976
            :.:..|..|.|.|......|..::|...|.|..|.. |...::.|.: .....|.|.|...||.|
  Rat  2823 QTFPENSRCSWTVITHESKHWEISFDSNFRIPSSDSQCQNSFVKVWE-GRLMINKTLLATSCGDV 2886

  Fly  2977 APEMINTTSPYLRLIFRSDGDVVADGFLAKFERNCGGLLYADSTEQELASPGFPNGYEKYLQCNW 3041
            ||..|.|:......:|:|: ::.|.||.|.|...||...  :::..::.||.||..|:..:.|.:
  Rat  2887 APSPIVTSGNIFTAVFQSE-EMAAQGFSASFISRCGRTF--NTSTGDIISPNFPKQYDNNMNCTY 2948

  Fly  3042 TIVPRSPSMGGVLVSFVNFDLE--QGPISVCLYDNLTVTTKDKGKDPQQT---TLCGVKHNHEYR 3101
            .|.....|:  |:::||:|.||  ......|.:|.|.:.   ||::...|   |:||.:......
  Rat  2949 LIDADPQSL--VILTFVSFHLEDRSAITGTCDHDGLHII---KGRNLSSTPLVTICGSETLRPLT 3008

  Fly  3102 GKEYVNLLLRTDGSYSGRGFTLLYTSRLCGGIISRTSMVESPVQHTDNTLPPGSDCYWNLTAPAG 3166
            ....|.|...:|...:..||.:.|.:..||||.:.:|.:.....::.:..|....|.::|...:.
  Rat  3009 VDGPVLLNFYSDAYTTDFGFKISYRAITCGGIYNESSGILRSPSYSYSNYPNNLYCVYSLHVRSS 3073

  Fly  3167 YKFNIKFLFIDFEANSNCAYDGVEVFSGPIPDERYRWGRFCG--------RINEDLPLISIPQER 3223
            ....|:|...|...::.||:|.:|||.||....| ..|:|||        ..|..|.|:
  Rat  3074 RVIIIRFNDFDVAPSNLCAHDFLEVFDGPSIGNR-SLGKFCGSTRPQTVKSTNSSLTLL------ 3131

  Fly  3224 GIIHSF-SDDRDPSRG----FRALVRVMPNCDEKISLNGSSRYVYSKFNNAGGYQNDLDCQIVFR 3283
                 | :|....:||    ||..:.....|...::.:..| :|....::.|.|...|.| |.:.
  Rat  3132 -----FKTDSSQTARGWKIFFRETIGPQQGCGGYLTEDNQS-FVSPDSDSNGRYDKGLSC-IWYI 3189

  Fly  3284 VNPDQQ-ISVEFSNFHVQ---DTDGCRSDYVELRDGGGTFADIIGRFCGQNQPPTLRTTRHTLYM 3344
            |.|:.: :.:.|:.|.::   ....|..|||::.||....:.:.|:|||...|....::.:.|..
  Rat  3190 VAPENKLVKLTFNVFTLEGPSSAGSCVYDYVQIADGASINSYLGGKFCGSRMPAPFISSGNFLTF 3254

  Fly  3345 RFVTDNKVTDTGFQVTINAIPRLCGSSEITLSADGTKEVTINSPARTPGGNYPNGVSCFWKIKGD 3409
            :||:|..|...||..|...:...||.   |.:|..|.:...:......|..|.   :|.|.|...
  Rat  3255 QFVSDVTVEMRGFNATYTFVDMPCGG---TYNATSTPQNASSPHLSNIGRPYS---TCTWVIAAP 3313

  Fly  3410 SLLRVQFVNFDLHGPNQNGSCVDDYLKIYNSEDAPLLEQGLGTDLVFNGQTSSKNGFGFATEHVY 3474
            ...:||...:||..|:|:  |...||::                     |.|.:.|....|:  :
  Rat  3314 PQQQVQITVWDLQLPSQD--CSQSYLEL---------------------QDSVQTGGNRVTQ--F 3353

  Fly  3475 CG---NVKPDIYYGRSSEVYLKFRSKGLEQHG--GFQLQVALNSNRERHYDGLQGRV-------H 3527
            ||   ...| ::|...|...:.|:|..|.::.  .|..|:| :.|||  |:...|.:       :
  Rat  3354 CGANYTTLP-VFYSSMSTAVVVFKSGVLNRNSQVQFSYQIA-DCNRE--YNQTFGNLKSPGWPQN 3414

  Fly  3528 LSQSADCNIIIRAPPNYTLSL-YYTELIFGTYDCEMENLEVFD---RTNRSLQRVCSFVDMGKSL 3588
            ...:.||.||:|||.|:::|| :|...:..:..|..:.|||.:   .|:..|.:.||.: :...:
  Rat  3415 YDNNLDCTIILRAPQNHSISLFFYWFQLEDSRQCMNDFLEVRNGGSSTSPLLDKYCSNL-LPNPV 3478

  Fly  3589 FSNANELRLQMKTGSYLTS--LDLTYLASPVEKGPGCGGQFYNTEGIFSNPFYPNNVRNNSECQW 3651
            ||.:|||.|...:...:|:  .::.:.:|    ..||||.....||||:||.:|::..||:.|:|
  Rat  3479 FSQSNELYLHFHSDHSVTNNGYEIIWTSS----AAGCGGTLLGDEGIFTNPGFPDSYPNNTHCEW 3539

  Fly  3652 IVRVPSNNVVFLTFEVFNLGSKTTCHTDYLQILEQDATGEEREMRRF---CGEDN---PKYYKSR 3710
            .:..||...|.:.|...::.|...|..:||.:.    .|.:.....|   ||.:.   |.|..|.
  Rat  3540 TIVAPSGRPVSVGFPFLSIDSSGGCDQNYLIVF----NGPDANSPPFGPLCGINTGIAPFYASSN 3600

  Fly  3711 RSQVLVRFH 3719
            |  |.:|||
  Rat  3601 R--VFIRFH 3607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011	15/33 (45%)
		EGF_CA	192..233	CDD:238011	19/40 (48%)
		EGF_CA	282..322	CDD:214542	20/41 (49%)
		EGF_3	328..366	CDD:289699	23/37 (62%)
		EGF	430..457	CDD:278437	10/26 (38%)
		EGF_CA	469..503	CDD:238011	12/33 (36%)
		CUB	509..622	CDD:238001	46/112 (41%)
		CUB	627..737	CDD:238001	49/111 (44%)
		CUB	744..849	CDD:294042	33/107 (31%)
		CUB	853..970	CDD:238001	35/117 (30%)
		CUB	978..1094	CDD:238001	45/115 (39%)
		CUB	1100..1211	CDD:238001	34/112 (30%)
		CUB	1216..1330	CDD:238001	35/115 (30%)
		CUB	1446..1549	CDD:238001	40/107 (37%)
		CUB	1554..1667	CDD:238001	39/112 (35%)
		CUB	1792..1899	CDD:238001	50/108 (46%)
		CUB	1910..1998	CDD:294042	30/103 (29%)
		CUB	2019..2133	CDD:238001	36/118 (31%)
		CUB	2140..2242	CDD:238001	36/114 (32%)
		CUB	2263..2379	CDD:238001	32/115 (28%)
		CUB	2385..2511	CDD:238001	25/146 (17%)
		CUB	2516..2630	CDD:238001	31/118 (26%)
		CUB	<2833..2892	CDD:294042	14/74 (19%)
		CUB	2898..3008	CDD:238001	29/110 (26%)
		CUB	3011..3127	CDD:238001	31/120 (26%)
		CUB	3130..3241	CDD:238001	32/123 (26%)
		CUB	3254..3363	CDD:238001	30/112 (27%)
		CUB	3379..3508	CDD:238001	28/133 (21%)
		CUB	3531..3601	CDD:294042	25/73 (34%)
		CUB	3623..3733	CDD:238001	34/103 (33%)
Cubn	NP_445784.3	cubilin_NTD	38..132	CDD:412063	23/93 (25%)
		Interaction with AMN. /evidence=ECO:0000250\|UniProtKB:O60494	39..46		1/6 (17%)
		EGF_CA	133..164	CDD:238011	4/30 (13%)
		EGF_CA	167..207	CDD:238011	20/39 (51%)
		EGF_CA	260..301	CDD:214542	16/50 (32%)
		EGF_CA	302..345	CDD:214542	23/44 (52%)
		EGF_3	350..387	CDD:403986	17/36 (47%)
		EGF_CA	400..430	CDD:238011	15/33 (45%)
		EGF_CA	432..468	CDD:238011	11/35 (31%)
		CUB	474..585	CDD:238001	43/110 (39%)
		CUB	590..699	CDD:238001	45/108 (42%)
		CUB	708..815	CDD:238001	35/107 (33%)
		CUB	817..927	CDD:238001	37/111 (33%)
		CUB	932..1041	CDD:238001	31/111 (28%)
		CUB	1048..1157	CDD:395345	33/111 (30%)
		CUB	1165..1275	CDD:238001	39/109 (36%)
		CUB	1278..1388	CDD:238001	34/120 (28%)
		CUB	1391..1505	CDD:238001	39/118 (33%)
		CUB	1510..1617	CDD:238001	39/109 (36%)
		CUB	1620..1733	CDD:238001	34/120 (28%)
		CUB	1738..1847	CDD:238001	42/112 (38%)
		CUB	1852..1962	CDD:238001	40/118 (34%)
		CUB	1978..2088	CDD:238001	31/119 (26%)
		CUB	2092..2212	CDD:238001	40/133 (30%)
		CUB	2217..2333	CDD:238001	35/129 (27%)
		CUB	2336..2447	CDD:238001	28/131 (21%)
		CUB	2452..2564	CDD:238001	27/111 (24%)
		CUB	2570..2686	CDD:238001	32/140 (23%)
		CUB	2689..2800	CDD:238001	25/112 (22%)
		CUB	2805..2918	CDD:238001	21/128 (16%)
		CUB	2920..3034	CDD:238001	31/114 (27%)
		CUB	3037..3148	CDD:238001	30/115 (26%)
		CUB	3157..3273	CDD:238001	31/128 (24%)
		CUB	3278..3392	CDD:238001	32/117 (27%)
		CUB	3395..3506	CDD:238001	25/113 (22%)
		CUB	3511..3623	CDD:238001	35/124 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6336
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37434
Inparanoid	1	1.050	1489	1.000	Inparanoid score	I96
OMA	1	1.010	-	-		QHG46457
OrthoDB	1	1.010	-	-		D3206at33208
OrthoFinder	1	1.000	-	-		FOG0006182
OrthoInspector	1	1.000	-	-		oto97375
orthoMCL	1	0.900	-	-		OOG6_106358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4462
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.880