DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn and SVEP1

DIOPT Version :9

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:NP_699197.3 Gene:SVEP1 / 79987 HGNCID:15985 Length:3571 Species:Homo sapiens


Alignment Length:2945 Identity:562/2945 - (19%)
Similarity:857/2945 - (29%) Gaps:1149/2945 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 NSCASGPCENGGTCYNTYTGFRCQCRSAFEGTKCEMDVNECALYEGTDLGCQNGGQCQNHFGTYS 220
            :.|...||.|.|||.....|:.|.|...:.|.|||.|::||     :.|.|.|.|.|::..|.:.
Human  1195 HECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDEC-----SPLPCLNNGVCKDLVGEFI 1254

  Fly   221 CLCQPGWHGMHCTQRKADCSQSSAWELCGHGSCVPSADDAGYRCICEPGWKTNGLTPICGEDVDE 285
            |.|..|:.|..|.:...:||.|..   ...|.||...  |||||.|..|:.              
Human  1255 CECPSGYTGQRCEENINECSSSPC---LNKGICVDGV--AGYRCTCVKGFV-------------- 1300

  Fly   286 CSDSAAHKPCSTSCINLPGSFTCAPCPAGLTGNGVSCR-DLDECQTNNGGCSLSPKVDCINTYGS 349
                                             |:.|. :::|||                    
Human  1301 ---------------------------------GLHCETEVNECQ-------------------- 1312

  Fly   350 YHCGECPVGWTGDGRKCERSPQDIDIPAGQTPRTCPAGNNPCYPTASCFLISGTTSCRCPMGMVG 414
                                                  :|||...|.|....|...|:||.|.:|
Human  1313 --------------------------------------SNPCLNNAVCEDQVGGFLCKCPPGFLG 1339

  Fly   415 TGYGPNGCVNGTTTNCKENPCLNGGICLFAGPSNYTCLCPIGFRPPICEPQPSPCDQHPCKNGGR 479
            |..|.|      ...|...||.||..|. .|.:::.|||..||....||...:.|..:||:|...
Human  1340 TRCGKN------VDECLSQPCKNGATCK-DGANSFRCLCAAGFTGSHCELNINECQSNPCRNQAT 1397

  Fly   480 CRPTTSGDLFVCQCLPGYRGRLCETRFSS----------------CNGMLSAQSGRLRYPPEGTG 528
            |....:.  :.|:|.||:.|:.|||..|:                .:|||.:.            
Human  1398 CVDELNS--YSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDGMLPSL------------ 1448

  Fly   529 YEHNAQCAWVIRTNESLVVNVTFNSFDVEDSTECRFDWLQINDGRSAAAQIIGRYCGNHLPHGGN 593
              |...|.:.:::::.:...... |:.|::.::   :.|.:.|.......:.||....:.|.   
Human  1449 --HALTCTFWMKSSDDMNYGTPI-SYAVDNGSD---NTLLLTDYNGWVLYVNGREKITNCPS--- 1504

  Fly   594 IVSSGNQLYLWFRSDNSTAKEGFDLTWNSMEPQCGGRLNFETHGTLASPGS--------PGN--- 647
             |:.|.    |..         ..:||.|    ..|.......|.|:..|:        ||.   
Human  1505 -VNDGR----WHH---------IAITWTS----ANGIWKVYIDGKLSDGGAGLSVGLPIPGGGAL 1551

  Fly   648 -YPKNRDCRWQLVAPTTKRIKLTFFSLQLEQHANCNFDYVLIKDSISGRELAKYCTTGAPAPLLL 711
             ..:.:|.:.:..:|....:. :...|.|       :||||....:      |...|..|..|..
Human  1552 VLGQEQDKKGEGFSPAESFVG-SISQLNL-------WDYVLSPQQV------KSLATSCPEELSK 1602

  Fly   712 PTHLAEIHFHSDAEGSDTGFQLHYSVEER------VPGCGG----VYTAKEGTISESSTANTEPG 766
            ...||...|.|...|.       ..::.:      .|..||    :.||.|         :.:||
Human  1603 GNVLAWPDFLSGIVGK-------VKIDSKSIFCSDCPRLGGSVPHLRTASE---------DLKPG 1651

  Fly   767 ---GVSCEYEIHLAVGEQVVIQFARLELDPLDCLEVLDITDEGGSILQ-----EKI-CGSDASRL 822
               .:.|:....| ||..|  |:         ||       ..|...|     |:| ||.     
Human  1652 SKVNLFCDPGFQL-VGNPV--QY---------CL-------NQGQWTQPLPHCERISCGV----- 1692

  Fly   823 NPPTFTSEFNRLKIKFYARAGSFQLNYRMACDYKLNNEQGTITSPGYPNLTRSDRICTYTISTAT 887
             ||...:.|:... .||  |||       ...|:.||        ||..|..|...||       
Human  1693 -PPPLENGFHSAD-DFY--AGS-------TVTYQCNN--------GYYLLGDSRMFCT------- 1731

  Fly   888 NTVISLKRIDFQLTNGESDDD-DNDECLTTN--------LRINDGLNRKILGPYC--GKN----- 936
                     |....||.|... |.|||...:        |.::.......:.||.  |||     
Human  1732 ---------DNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPI 1787

  Fly   937 ------QPEENFVSETNYLQLHLSTDVDSMGRGFKFE----YRALATGNDKCGGVHTRSGDHIRL 991
                  .||..          |.|.::.::|....|.    |:.:......|    ..||:    
Human  1788 KCKAPGNPENG----------HSSGEIYTVGAEVTFSCQEGYQLMGVTKITC----LESGE---- 1834

  Fly   992 PVHDDSYAGEATCYWVIMAPANKAIRLHWNSFSLENAVDCIYDYLEIYDSLGAQV---------- 1046
                          |..:.|..||:.....:.. ||.  ||.   |:..:.|::|          
Human  1835 --------------WNHLIPYCKAVSCGKPAIP-ENG--CIE---ELAFTFGSKVTYRCNKGYTL 1879

  Fly  1047 -NDERSKPLAKYCGNSVPEDLLSHSRQLVLKFVSDYSESDGGFDLTYTFEDRAKCGGHIHASSGE 1110
             .|:.|..||    ||    ..|||..:.                     :..||....:.::|:
Human  1880 AGDKESSCLA----NS----SWSHSPPVC---------------------EPVKCSSPENINNGK 1915

  Fly  1111 --LTSPEYPANYSAGLDCDWHLTGTIDHLLEIQVENFELEQSPNCSADYLEVRNGGGTDSPLIGR 1173
              |:...|.:..|...|..:.|.|  ..::|...........|.|.               |:  
Human  1916 YILSGLTYLSTASYSCDTGYSLQG--PSIIECTASGIWDRAPPACH---------------LV-- 1961

  Fly  1174 FCGRDIPARIPGFSHEMRLILHTDSAINGRGFRLRWRIFAFGC-----------------GGSLR 1221
            |||.  |..|            .|:.|.|..|..| ....:.|                 |...|
Human  1962 FCGE--PPAI------------KDAVITGNNFTFR-NTVTYTCKEGYTLAGLDTIECLADGKWSR 2011

  Fly  1222 SNMGAIS-----SPRYPNSYPNMAHCEWRISLHPGSGISLLIEDLELEGLSNCYYDSVKIYTGIK 1281
            |:...::     .|...::.|..||              .|..|:..      ||.|    .|..
Human  2012 SDQQCLAVSCDEPPIVDHASPETAH--------------RLFGDIAF------YYCS----DGYS 2052

  Fly  1282 LPNQSPCKVLCKDDDLHNPLIQLENNKGTIV--FDSDASNTFRGF-----RISYK-ANCIRNLTA 1338
            |.:.|  ::||             |.:|..|  ...|.......|     .:||. ...:.....
Human  2053 LADNS--QLLC-------------NAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKF 2102

  Fly  1339 TTGTIESLNYMEPFWETIPINCSWTIRAPKGNRVLVEVSHLARHEQHVPTATMPGGLYIVDGRNV 1403
            ..|::.|...||.|    .:|.|..|..                        |.||.:       
Human  2103 AAGSVVSFKCMEGF----VLNTSAKIEC------------------------MRGGQW------- 2132

  Fly  1404 QEIVTPQAMNIS------GEVLTVVHN-ASNVNFQLDYRIDGCMEELRGTFGFFQSPNYPKMYPN 1461
                .|..|:|.      ||..::::. ||..|:..     |.|.......||:           
Human  2133 ----NPSPMSIQCIPVRCGEPPSIMNGYASGSNYSF-----GAMVAYSCNKGFY----------- 2177

  Fly  1462 NLECYWLITVEQDSAIELT---INNIDLEDSPNCTKDALTVSNHKNSVEVHERHCGSTTKLVITS 1523
                   |..|:.|..|.|   .:.|     |.|                |...||...|:   .
Human  2178 -------IKGEKKSTCEATGQWSSPI-----PTC----------------HPVSCGEPPKV---E 2211

  Fly  1524 SGHRLH---------VRFISDNSHNGLG-------------FEATYRTVKATCGGKLTARNGVIE 1566
            :|...|         ||:..:..:..:|             .|:....|...||.....:||.::
Human  2212 NGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMK 2276

  Fly  1567 SPNYPLNYPAHSRC----------EWQVEVS---------------------QHHQIVFEMADLN 1600
            ..|:.:.......|          .|..:.|                     ..:|:|  :.:|.
Human  2277 GENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLV--LKELT 2339

  Fly  1601 LESG---YDCNWDYLEAYDLTEDDTEGERLFKVCGDETEDDKLLSSSSNMAVVRFISDDSVSKKG 1662
            .|.|   :.|.    |.:.|     :|..:.|....:..:|........:.....:....|....
Human  2340 TEVGVVTFSCK----EGHVL-----QGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPS 2395

  Fly  1663 FRLHFHESCGQTIIVDETMFDYIQMSRQAARNESCLWVFQAVEPNKRIIFTPTHVKLREDANQQY 1727
            ..|||    |.|:                  ..||:..| .:..|...:..|       |.....
Human  2396 SALHF----GSTV------------------KYSCVGGF-FLRGNSTTLCQP-------DGTWSS 2430

  Fly  1728 PTEGDCLNVGVKIYEGTEPQGTPR--------------LKFCRSHPPALISNGQALTVSVPLQLV 1778
            |.. :|:.|     |..:|:..|.              |..|:   |.....|...|      |.
Human  2431 PLP-ECVPV-----ECPQPEEIPNGIIDVQGLAYLSTALYTCK---PGFELVGNTTT------LC 2480

  Fly  1779 EEFQGHYMTMDTSCGSI-----YNALSGKF--TSPYYPASYPPNIECLWLLEASMGNSLSLTLES 1836
            .| .||::....:|.:|     ...|:|||  |..:|..:...:....:.||   |.|....||:
Human  2481 GE-NGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLE---GPSALTCLET 2541

  Fly  1837 MDLE-KSESCNRDYLEVREESESGQLIGVYCGNEVPGVIHSRGAIWMKFKSDDDNVGEGFMASYN 1900
            .|.: .:.|||..:.:..:..|:|         .|.|..:|.|||.:.      :...||..:.:
Human  2542 GDWDVDAPSCNAIHCDSPQPIENG---------FVEGADYSYGAIIIY------SCFPGFQVAGH 2591

  Fly  1901 YEHHNELNGTEGTIES---------PHFP----SKFQD------------PVPY----------- 1929
            .....|.:|...:|.:         ||..    :|.:|            .|||           
Human  2592 AMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGA 2656

  Fly  1930 ---SWRITVDKEYVVAISLLY---LRDLDQPHLNFYDGYSDIGARIEVTDPDETIISSTNVVYFT 1988
               :|..|.:.....:.:.||   :.....|      ||..:|..:.:...|.|           
Human  2657 VAKTWENTKESPATHSSNFLYGTMVSYTCNP------GYELLGNPVLICQEDGT----------- 2704

  Fly  1989 SNRGPFKLNWNRLSKEALRSN---RTAEERTRQCGNQLITIDRSVIGFH-----SPGY-PNGYEQ 2044
                     ||..:...:...   .||.|      |..:....:.:|..     .||: ..|.:.
Human  2705 ---------WNGSAPSCISIECDLPTAPE------NGFLRFTETSMGSAVQYSCKPGHILAGSDL 2754

  Fly  2045 DL---NCFW----------TLVPSNPAMHAVLTLSQID-LEIFSEDCIADYVKIFSGS------D 2089
            .|   |..|          :....||.|:..:..|... |.....:|...||  .:|:      |
Human  2755 RLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYV--LNGTERRTCQD 2817

  Fly  2090 LQNWSELRTL-----CSLPTESSDRVFHGRPYL---RVEFVTDPSVNKTGFNGIVRTACGSEITA 2146
            .:||.|...:     ||.|..|::....|..|.   .:|:..:......|....|..|.||...|
Human  2818 DKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGA 2882

  Fly  2147 SKGLVNITEILKVLPRPNHDCVWTIKVRQGRRIKIDFPDFQLQNNMASG---------SSDCRNY 2202
            :.                 |||         .::...|. ||.|.:..|         :..|...
Human  2883 TP-----------------DCV---------PVRCATPP-QLANGVTEGLDYGFMKEVTFHCHEG 2920

  Fly  2203 LLLR---------NGN-DEDSPFLGRGKYC---EDVVHEVLNTSS--NKAYI--------KFHFA 2244
            .:|.         :|| |.:.| |.:...|   ||:.|...|..|  :..:|        |.|..
Human  2921 YILHGAPKLTCQSDGNWDAEIP-LCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGN 2984

  Fly  2245 SPPRFLVS-------------------FRFEELRYTD-----SGRIR------------LSASGD 2273
            |..|.|.:                   ..:..:..||     :.||:            ::...|
Human  2985 SSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEAD 3049

  Fly  2274 EQFISSPYYPHLPHPHSECIWIVEAPPEHRIMLHFQGAFDMLDATGEPEE------CQREFVLIN 2332
            .|:.|.  :||.  .|:.|..:...|          .||  :..|...:|      |:..:|:  
Human  3050 GQWSSG--FPHC--EHTSCGSLPMIP----------NAF--ISETSSWKENVITYSCRSGYVI-- 3096

  Fly  2333 DGSTEL-RPEIGRY-----------CGNRKPDTI---YSTG------NQMRIR----YFTDVSEP 2372
            .||::| ..|.|.:           ||:  |.::   .:||      :::::|    |..|..  
Human  3097 QGSSDLICTEKGVWSQPYPVCEPLSCGS--PPSVANAVATGEAHTYESEVKLRCLEGYTMDTD-- 3157

  Fly  2373 HMGFNASLSVARCGGSFHSPEGVIASPSR-------DLLLIHEE----GKQLQ-ECV--YTIELE 2423
                ..:.:..:.|..|  ||.:..||.:       ..:|:|.:    .:|:. .|.  ||.|..
Human  3158 ----TDTFTCQKDGRWF--PERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGV 3216

  Fly  2424 KGSTIDLTSEYLQIPTLRNGSCSQRNHLMLEEMDAFGLDGEEKIVDTLMLCGMEAKHLISETNKI 2488
            ..|...|...:  .|...:.|||.                        :.||   |....|...:
Human  3217 NISVCQLDGTW--EPPFSDESCSP------------------------VSCG---KPESPEHGFV 3252

  Fly  2489 V-FRYRFLDGIPAE-NQGFRLKYTSLGSR---CGETIYASVGV-------LQTP----------- 2530
            | .:|.|...|..: ..|:.|:    |:|   |.|....|.||       .:||           
Human  3253 VGSKYTFESTIIYQCEPGYELE----GNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIE 3313

  Fly  2531 --------------GYPLGVPHPMHC----KWQVQVPKGR------------RVRLEILDFNTGT 2565
                          ||.|..|...||    .|...||..:            ...|...:|....
Human  3314 NRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQ 3378

  Fly  2566 NMDLRGRLGF----RGRLTVAND-------FKMQSILGRYNVDPPAEVLSSDNTMGIDAFLLPIV 2619
            |:.::.|.||    .|.:|...|       .|.:.|    :..|||.|   :|     |....:.
Human  3379 NVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKI----SCGPPAHV---EN-----AIARGVH 3431

  Fly  2620 QNHGIKLRFSAYGSSSCPGF 2639
            ..:|..:.:|.|......||
Human  3432 YQYGDMITYSCYSGYMLEGF 3451

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 EGF_CA 156..190 CDD:238011 12/33 (36%)
EGF_CA 192..233 CDD:238011 13/40 (33%)
EGF_CA 282..322 CDD:214542 1/39 (3%)
EGF_3 328..366 CDD:289699 2/37 (5%)
EGF 430..457 CDD:278437 10/26 (38%)
EGF_CA 469..503 CDD:238011 10/33 (30%)
CUB 509..622 CDD:238001 17/112 (15%)
CUB 627..737 CDD:238001 23/121 (19%)
CUB 744..849 CDD:294042 29/117 (25%)
CUB 853..970 CDD:238001 30/142 (21%)
CUB 978..1094 CDD:238001 23/126 (18%)
CUB 1100..1211 CDD:238001 22/112 (20%)
CUB 1216..1330 CDD:238001 25/143 (17%)
CUB 1446..1549 CDD:238001 20/127 (16%)
CUB 1554..1667 CDD:238001 21/146 (14%)
CUB 1792..1899 CDD:238001 28/114 (25%)
CUB 1910..1998 CDD:294042 18/129 (14%)
CUB 2019..2133 CDD:238001 29/147 (20%)
CUB 2140..2242 CDD:238001 26/133 (20%)
CUB 2263..2379 CDD:238001 29/158 (18%)
CUB 2385..2511 CDD:238001 29/141 (21%)
CUB 2516..2630 CDD:238001 34/172 (20%)
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
SVEP1NP_699197.3 VWA 84..258 CDD:278519
GCC2_GCC3 310..360 CDD:285001
CCP 378..434 CDD:153056
CCP 438..494 CDD:153056
DUF5011 560..642 CDD:295940
DUF5011 643..722 CDD:295940
O-glycosylated at one site 887..894
GCC2_GCC3 1005..1052 CDD:285001
GCC2_GCC3 1059..1106 CDD:285001
GCC2_GCC3 1113..1160 CDD:285001
EGF 1197..1225 CDD:278437 10/27 (37%)
EGF_CA 1231..1267 CDD:238011 13/40 (33%)
EGF_CA 1269..1305 CDD:238011 14/87 (16%)
EGF_CA 1308..1342 CDD:238011 15/91 (16%)
EGF_CA 1345..1381 CDD:238011 13/42 (31%)
EGF_CA 1383..1419 CDD:238011 10/37 (27%)
LamG 1424..1622 CDD:304605 41/257 (16%)
Sushi 1628..1685 CDD:278512 18/84 (21%)
CCP 1690..1743 CDD:153056 23/92 (25%)
EGF_CA 1745..1783 CDD:214542 9/37 (24%)
PHA02927 1789..2017 CDD:222943 57/328 (17%)
CCP 1789..1843 CDD:153056 12/85 (14%)
CCP 1847..1901 CDD:153056 16/88 (18%)
CCP 1905..1958 CDD:153056 10/54 (19%)
CCP 1963..2016 CDD:153056 13/67 (19%)
Sushi 2021..2078 CDD:278512 18/95 (19%)
CCP 2083..2136 CDD:153056 14/91 (15%)
PHA02927 2137..2376 CDD:222943 49/296 (17%)
CCP 2146..2199 CDD:153056 16/80 (20%)
CCP 2204..2260 CDD:153056 9/58 (16%)
CCP 2264..2318 CDD:153056 8/53 (15%)
CCP 2323..2377 CDD:153056 11/64 (17%)
CCP 2381..2436 CDD:153056 13/85 (15%)
CCP 2440..2494 CDD:153056 11/63 (17%)
PHA02927 2498..2770 CDD:222943 59/321 (18%)
CCP 2498..2551 CDD:214478 13/55 (24%)
CCP 2556..2608 CDD:153056 13/66 (20%)
CCP <2670..2713 CDD:153056 10/68 (15%)
CCP 2717..2771 CDD:153056 11/59 (19%)
PHA02927 2770..3003 CDD:222943 53/262 (20%)
CCP 2775..2828 CDD:214478 13/54 (24%)
CCP 2833..2887 CDD:153056 14/70 (20%)
Cell attachment site. /evidence=ECO:0000255 2845..2847 0/1 (0%)
CCP 2891..2945 CDD:153056 12/55 (22%)
CCP 2949..3002 CDD:214478 12/52 (23%)
Sushi 3007..3059 CDD:278512 8/53 (15%)
CCP 3064..3118 CDD:153056 13/67 (19%)
Sushi 3181..3231 CDD:278512 10/51 (20%)
CCP 3241..3295 CDD:153056 17/60 (28%)
CCP 3299..3353 CDD:153056 11/53 (21%)
CCP 3357..3412 CDD:153056 10/54 (19%)
CCP 3416..3469 CDD:153056 11/44 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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