DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn and Pdgfd

DIOPT Version :10

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:NP_082200.1 Gene:Pdgfd / 71785 MGIID:1919035 Length:370 Species:Mus musculus


Alignment Length:268 Identity:70/268 - (26%)
Similarity:106/268 - (39%) Gaps:84/268 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1800 SGKFTSPYYPASYPPNIECLWLLEASMGNSLSLTLE-SMDLEKSES--CNRDYLEVREESESGQL 1861
            :|...||.:|.|||.|:...|.|.:.....:.|:.: ...||::|:  |..|::||.|.|||..:
Mouse    61 NGHVQSPRFPNSYPRNLLLTWWLRSQEKTRIQLSFDHQFGLEEAENDICRYDFVEVEEVSESSTV 125

  Fly  1862 I-GVYCGN-EVPGVIHSR-GAIWMKFKSDDDNVGE-GFMASYNY------EHHNELNGTEGTIE- 1915
            : |.:||: |:|..|.|| ..|.:.|||||..|.: ||...|::      |..:|.|....|.. 
Mouse   126 VRGRWCGHKEIPPRITSRTNQIKITFKSDDYFVAKPGFKIYYSFVEDFQPEAASETNWESVTSSF 190

  Fly  1916 ---SPHFPSKFQDPV------------------------PYSWRITVDKEYVVAISLLYLRDLDQ 1953
               |.|.|| ..||.                        |.||:..::..|           ||.
Mouse   191 SGVSYHSPS-ITDPTLTADALDKTVAEFDTVEDLLKHFNPVSWQDDLENLY-----------LDT 243

  Fly  1954 PHLNFYDG--YSDIGARIEVTDPDETI-----------------ISSTNVVYFT---------SN 1990
            ||   |.|  |.|..:::::...::.:                 :..||.|:|.         .|
Mouse   244 PH---YRGRSYHDRKSKVDLDRLNDDVKRYSCTPRNHSVNLREELKLTNAVFFPRCLLVQRCGGN 305

  Fly  1991 RGPFKLNW 1998
            .|...:||
Mouse   306 CGCGTVNW 313

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 cubilin_NTD 21..149 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_CA 324..367 CDD:214542
EGF 430..457 CDD:394967
EGF_CA 469..503 CDD:238011
CUB 509..622 CDD:238001
CUB 627..737 CDD:238001
CUB 744..849 CDD:412131
CUB 853..970 CDD:238001
CUB 978..1094 CDD:238001
CUB 1100..1211 CDD:238001
CUB 1216..1330 CDD:238001
CUB 1446..1549 CDD:238001
CUB 1554..1667 CDD:238001
CUB 1792..1899 CDD:238001 39/105 (37%)
CUB 1910..1998 CDD:412131 25/143 (17%)
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:412131
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:412131
CUB 3623..3733 CDD:238001
PdgfdNP_082200.1 CUB 55..169 CDD:238001 40/107 (37%)
PDGF 270..365 CDD:238079 8/44 (18%)
Blue background indicates that the domain is not in the aligned region.

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