DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cubn and Svep1

DIOPT Version :9

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:XP_038966967.1 Gene:Svep1 / 685899 RGDID:1588987 Length:3705 Species:Rattus norvegicus


Alignment Length:2693 Identity:514/2693 - (19%)
Similarity:773/2693 - (28%) Gaps:1113/2693 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 NSCASGPCENGGTCYNTYTGFRCQCRSAFEGTKCEMDVNECALYEGTDLGCQNGGQCQNHFGTYS 220
            :.|...||.|.|||.....|:.|.|...:.|.|||.|::||     :.|.|.|||.|::..|.::
  Rat  1331 HECFLNPCHNSGTCQQLGRGYVCLCPPGYTGLKCETDIDEC-----SSLPCLNGGICRDKVGGFT 1390

  Fly   221 CLCQPGWHGMHCTQRKADCSQSSAWELCGHGSCVPSADDAGYRCICEPGWKTNGLTPICGEDVDE 285
            |.|..|:.|..|.:...:||.|..   ...|:|....  |.|||.|..|:.              
  Rat  1391 CECSSGYTGQICEENINECSSSPC---LNKGTCTDGL--ASYRCTCVSGYV-------------- 1436

  Fly   286 CSDSAAHKPCSTSCINLPGSFTCAPCPAGLTGNGVSCR-DLDECQTNNGGCSLSPKVDCINTYGS 349
                                             ||.|. |::|||                    
  Rat  1437 ---------------------------------GVHCETDVNECQ-------------------- 1448

  Fly   350 YHCGECPVGWTGDGRKCERSPQDIDIPAGQTPRTCPAGNNPCYPTASCFLISGTTSCRCPMGMVG 414
                                                  ::||...|.|....|..||:||.|.:|
  Rat  1449 --------------------------------------SSPCLNNAVCKDQVGGFSCKCPPGFLG 1475

  Fly   415 TGYGPNGCVNGTTTNCKENPCLNGGICLFAGPSNYTCLCPIGFRPPICEPQPSPCDQHPCKNGGR 479
            |....|      ...|...||.||..|. .|.:::.|.||.||..|.||...:.|..:||:|...
  Rat  1476 TRCEKN------VDECLSQPCQNGATCK-DGANSFRCQCPAGFTGPHCELNINECQSNPCRNQAT 1533

  Fly   480 CRPTTSGDLFVCQCLPGYRGRLCETRFSSCNGMLSAQSG-RLRYPPEGT-GYE---------HNA 533
            |....:.  :.|:|.||:.||.|||         ...|| .|.:...|. ||.         |..
  Rat  1534 CVDELNS--YSCKCRPGFSGRRCET---------EQPSGFNLDFEVSGIYGYVLLDGVLPTLHAI 1587

  Fly   534 QCAWVIRTNESLVVNV-TFNSFDVEDSTECRF------DWL-------------QINDG------ 572
            .||:.:::::  |:|. |..|:.:|.:.:..|      .|:             .:|||      
  Rat  1588 TCAFWMKSSD--VINYGTPISYALEGNKDNTFLLTDYNGWVLYVNGKEKITNCPSVNDGIWHHIA 1650

  Fly   573 -----RSAAAQI----------IGRYCGNHLPHGG-------------------NIVSSGNQLYL 603
                 ...|.::          .|...|..:|.||                   :.|.|.:||.|
  Rat  1651 ITWTSTGGAWRVYIDGELSDSGTGLSVGKAIPGGGALVLGQEQDKKGEGFNPAESFVGSISQLNL 1715

  Fly   604 W--------FRSDNSTAKE----GFDLTWNSMEPQCGGRLNFETHGTLAS--------------- 641
            |        .:|..|:..|    |..|.|........|::..::.....|               
  Rat  1716 WDYVLSPQQVKSLASSCPEELSRGNVLAWPDFVSGITGKVKVDSSSIFCSDCPSLEGSVPHLRPA 1780

  Fly   642 -----PGS---------------PGNYPKNRDCRWQLVAPTTKRIKL--------TFFSLQLEQH 678
                 |||               |..|..|:. :|....|..:||:.        .|:|.: :.|
  Rat  1781 SGDRKPGSKVSLFCDPGFQMVGNPVQYCLNQG-QWSQPLPHCERIRCGLPPTLENGFYSAE-DLH 1843

  Fly   679 A------NCNFDYVLIKDSISGRELAKYCTTGAPAPLLLPTHLAEIHFHSDAEGSDTGFQLHYSV 737
            |      .|...|.|:.||      ..:||.......:.|:.|   .....|.|||.  ..|.|.
  Rat  1844 AGSTVTYQCTSGYYLLGDS------RMFCTDNGSWNGISPSCL---DVDECAVGSDC--SEHASC 1897

  Fly   738 ----EERVPGCGGVYTAKEGTISE----SSTANTEPG-------------GVSCEYEIHLAVGEQ 781
                ...:..|...||......:|    .:..|.|.|             ..||| |.|..||.:
  Rat  1898 LNTNGSYICSCKPPYTGDGKNCAEPVKCKAPENPENGHSLGKIYSVGAEVTFSCE-EGHQLVGVR 1961

  Fly   782 VVIQFARLELDPL--DCLEVLDITDEGGSILQEKICGSDASRLNPPTFTSEFNRLKIKFYARAGS 844
            .:......|.|.|  .| |.:.             ||:.....|.....|.|.         .||
  Rat  1962 KITCLESGEWDHLRPSC-EAIS-------------CGAPPVPENGGVDGSAFT---------YGS 2003

  Fly   845 FQLNYRMACD--YKL-NNEQGTITSPGYPNLTRSDRIC--------------TYTISTATNTVIS 892
             ::.||  ||  |.| .:|:....:.|  :.:.|..:|              .|.:|..|...|:
  Rat  2004 -KVRYR--CDKGYTLAGDEESACLASG--SWSHSSPVCELVKCSQPENINNGKYILSGLTYLSIA 2063

  Fly   893 LKRID----------FQLTNGESDDDDNDECLTTNL----RINDGLNRKILGPYCGKNQPEENFV 943
            ....:          .:.|...|.|.....|...:.    .:.|.|.       .|.|....|.|
  Rat  2064 SYSCEDGYSLQGPSLIECTASGSWDRAPPSCQLVSCGEPPMVKDALT-------TGSNFTFGNMV 2121

  Fly   944 SET---NYLQLHLSTDV-DSMGRGFKFEYRALATGNDKCGGVHTRSGDHIRLPVHD-------DS 997
            :.|   .|......|.: .:.|:.....::.||...|:...|...|.:.......|       |.
  Rat  2122 TYTCKEGYTLAGPDTIICQANGKWNSSNHQCLAVSCDEPPNVDHASPETAHRLFGDTAFYYCADG 2186

  Fly   998 YA----GEATC----YWVIMAPANKAIRLHWNSFSLENAVDCIYDYLEIYDSLGAQVNDERSKPL 1054
            |:    .:..|    .||  .|..:|:            ..||..:.|...|:...:.:..||  
  Rat  2187 YSLADNSQLICNAQGNWV--PPEGQAV------------PRCIAHFCEKPPSVSYSILESVSK-- 2235

  Fly  1055 AKYCGNSVPEDLLSHSRQLVLKFVSDYSESDGGFDLTYTFEDRAKCGGH----------IHASSG 1109
            ||:...||          :..|.:.       ||.|..:.:.....||.          |....|
  Rat  2236 AKFAAGSV----------VSFKCME-------GFVLNTSAKIECLRGGQWSPSPLSVQCIPVRCG 2283

  Fly  1110 ELTS--PEYPA--NYSAG----LDC--DWHLTGTIDHLLEI--------------------QVEN 1144
            |..|  ..||:  |||.|    ..|  .:::.|......|.                    :|||
  Rat  2284 EPPSITNGYPSGTNYSFGAVVAYSCHKGFYIKGEKKSTCEATGQWSRPLPTCHPVSCNEPPKVEN 2348

  Fly  1145 ----------FELEQSPNCSADY---------LEVRNGGGTDSPL--IGRFCGRDIPAR---IPG 1185
                      ||.|....|:..|         .:......:|:||  ....||:..|.:   :.|
  Rat  2349 GFLEHTTGRTFESEARFQCNPGYKAVGSPVFVCQANRHWHSDAPLSCTPLNCGKPPPIQNGFLRG 2413

  Fly  1186 FSHEMRLILHTDSAIN---GRGFRL------------RWR------------------------- 1210
            .|.|:      .|.:.   ..|:.|            :|.                         
  Rat  2414 ESFEV------GSKVQFVCNEGYELVGDNSWTCQKSGKWSKKPSPKCVPTKCAEPPLLENQLVLK 2472

  Fly  1211 -------IFAFGC--GGSLR--SNMGAISSPRYPNSYP--NMAHCE------WRI-----SLHPG 1251
                   :....|  |.:|:  |.:..:.|.::..|:|  .:..|:      :.:     :||.|
  Rat  2473 ELTSEVGVMTISCKEGHALQGPSVLKCLPSGQWNGSFPVCKLVLCQSPPLIPFGVPASSGALHFG 2537

  Fly  1252 SGISLLIED----------------------------------------LELEGLSNCYYDSVKI 1276
            |.:..|..|                                        :.::||:   |.|..:
  Rat  2538 STVKYLCVDGFFLRGNPIILCQVDGTWSSPLPECVPVECPQPEEILNGIIHVQGLA---YLSTTL 2599

  Fly  1277 YT---GIKLPNQSP--C---------KVLCKDDDLHNPLIQLENNKGTIVFDSDASNTF---RGF 1324
            ||   |.:|...:.  |         |.:|:..:...|...|.....::.|....:.|:   |||
  Rat  2600 YTCKPGFELVGNTTTLCGENGQWLGGKPMCRPIECPEPKEILNGQFSSVSFQYGQTITYSCDRGF 2664

  Fly  1325 RI-------------------SYKA-NCIRNLTATTGTIESLNYM-------------------- 1349
            |:                   |..| :|........|.:|..:|.                    
  Rat  2665 RLEGPKSLTCLETGNWDMDAPSCNAIHCSDPQPIENGFVEGADYRYGAMIIYSCFPGFQVVGHAM 2729

  Fly  1350 ----EPFWET-----IPINCSWTIRAPKGN--RV------------LVEVSHLARHEQHVPTATM 1391
                |..|.:     :||:|........|:  ||            ::||.:|..|.||:.    
  Rat  2730 QTCEETGWSSSSPTCVPIDCGLPPHIDFGDCTRVSDGQGYFVQEDDMMEVPYLTPHPQHLE---- 2790

  Fly  1392 PGGLYIVDGRNVQEIVTPQAMNISGEVLTVVHNASNVNF--QLDYRIDGCMEELRGTFGFFQSPN 1454
                           .|.:|..|:.|  ::|.:||...:  .:.||.:               |.
  Rat  2791 ---------------ATAKASEITEE--SLVPHASQFLYGTTVSYRCE---------------PG 2823

  Fly  1455 YPKMYPNNLECYWLITVEQDSAIELTINNIDLEDSPNC--TKDALTVSNHKNSVEVHERHCGSTT 1517
            |..:....|.|      ::|.....|        :|:|  .:..|.|:.....:...:...||..
  Rat  2824 YELLGIPVLVC------QEDGTWNGT--------APSCISIECDLPVAPENGFLHFTQTTMGSAA 2874

  Fly  1518 KLVITSSGHRL---HVRFISDNSHNGLGFEATY-RTVKATCGGKLTARNGVIESPNYPLNYPAHS 1578
            : .....||.|   |:|....|..    :..|. |....:|.......||.|:..:|......|.
  Rat  2875 Q-YSCKPGHVLEGSHLRLCLQNKQ----WSGTVPRCEVISCSEPNPLGNGSIKGNDYSYLGVLHY 2934

  Fly  1579 RCEWQVEVSQHHQIVFEMADLNLESGYDCN------------WDYLEAYDLTED------DTEGE 1625
            .|                     :|||..|            ||..|...|..|      .|.|:
  Rat  2935 EC---------------------DSGYVLNGTEKRTCQENKQWDGHEPVCLPVDCGSPPVPTNGQ 2978

  Fly  1626 RLFKVCGDETEDDKLLSSSSNMAVVRFISDDSVSKKGFRLHFHESCGQTIIVDETMFDYIQMSRQ 1690
                |.|:|..                          |:.....|||:..|:            :
  Rat  2979 ----VTGEEYT--------------------------FQKEIAYSCGEGFIL------------E 3001

  Fly  1691 AARNESCL----WVFQAVEPNKRIIFTPTHVKLREDANQQYP---TEGDCLNVGVK------IYE 1742
            .||:..||    |...          ||:.|.:|..|..|..   |:|  |:.|.|      ..|
  Rat  3002 GARSRVCLTNGSWSGT----------TPSCVPVRCPAPPQVANGVTDG--LDYGFKKEVTFHCLE 3054

  Fly  1743 GTEPQGTPRLKFCRSHPPALISNG---------QALTVSVPLQLVEEFQ--------GHYMTMDT 1790
            |...||||:|. |:       |||         :..|...|..|.:.|.        ||..    
  Rat  3055 GYVLQGTPKLT-CQ-------SNGTWDAEVPICKPATCGPPADLPQGFPNGFSFFHGGHIQ---- 3107

  Fly  1791 SCGSIYNALSGKFTSPYYPASYPPNIECL----WLLEASMGNSLSLTLESMDLEKSE------SC 1845
                 |...:|      |.....|:..||    |  ..|..:.|..|..:..:::..      .|
  Rat  3108 -----YQCFTG------YKLHGNPSRRCLPDGSW--SGSTPSCLPCTCSTPIIQQGTVNATDLGC 3159

  Fly  1846 NRDYLEVREESESG-QLIGV--------------------YCG--NEVPGVIHSRGAIWMKFKSD 1887
            .:   .|:.|...| :|:|:                    .||  ..||..|..:|:     .|:
  Rat  3160 GK---TVQIECFKGFKLLGLPEITCDANGQWSDFPLCEHADCGPLPTVPNGIVIKGS-----PSE 3216

  Fly  1888 DDNVGEGFMASYNYEHHNELNGTEGTIESPHFPSKFQDPVPYSWRITVDK----------EYVVA 1942
            |:.|.......|..:..::|..||..|.|..:|:  .:||......||..          |..|.
  Rat  3217 DNVVTYSCRPGYIIQGSSDLICTEKGIWSEPYPT--CEPVSCGPPPTVANAVATGEAHTYESKVK 3279

  Fly  1943 ISLL--YLRDLD--------------------------------------------QPHLNFYDG 1961
            :..|  |:.|.|                                            |..::..:|
  Rat  3280 LRCLEGYVVDTDTDTFTCQQDGRWFPERINCSPKTCPVPSNRTRIRVHGDDFQVNRQVSVSCTEG 3344

  Fly  1962 YSDIGARIEVTDPDET-------------------------IISS-----TNVVYFTSNRGPFKL 1996
            ::..||......||.|                         ::.|     :.|||........:.
  Rat  3345 FTYDGADRSTCQPDGTWEPPLSEESCIPVVCGQPESPEHGFVVGSEYSFGSTVVYQCDPGYELEG 3409

  Fly  1997 NWNRLSKEALR-SNRTAEERTRQCGNQLITIDRSVIGFHSPG-YPNGYEQDLNCFWTLVPSNPAM 2059
            |..|:.:|..: |.|.|..|..:|              .:|. :|||.....|     ..|.|::
  Rat  3410 NRERVCQENRQWSGRVAVCRESRC--------------EAPAEFPNGKAVLEN-----TTSGPSL 3455

  Fly  2060 ----HAVLTLSQIDLEIFSEDCIADYVKIFSGSDLQNWSELRTLCS---------LPTES--SDR 2109
                |...||....    ...|.|:          ..||.|..||.         :|..:  |:|
  Rat  3456 LFSCHRGYTLEGPP----EAHCTAN----------GTWSHLAPLCKPNPCPVPFVIPENALLSER 3506

  Fly  2110 VFHGRPYLRVEFVTDPSVN---KTGF----NGIVRTACGSEITASKGLVNITEILKVLPRPNHDC 2167
                      ||..:.:|:   :.||    |||:  .|                       |.|.
  Rat  3507 ----------EFYVNQNVSIKCREGFLLKGNGII--TC-----------------------NPDE 3536

  Fly  2168 VWTIKVRQGRRIKIDFPDFQLQNNMASG 2195
            .||....:..:|... |...::|.:|.|
  Rat  3537 TWTQTNARCEKISCG-PPTHVENAIARG 3563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 EGF_CA 156..190 CDD:238011 12/33 (36%)
EGF_CA 192..233 CDD:238011 14/40 (35%)
EGF_CA 282..322 CDD:214542 2/39 (5%)
EGF_3 328..366 CDD:289699 2/37 (5%)
EGF 430..457 CDD:278437 10/26 (38%)
EGF_CA 469..503 CDD:238011 11/33 (33%)
CUB 509..622 CDD:238001 37/195 (19%)
CUB 627..737 CDD:238001 30/158 (19%)
CUB 744..849 CDD:294042 26/123 (21%)
CUB 853..970 CDD:238001 26/151 (17%)
CUB 978..1094 CDD:238001 24/130 (18%)
CUB 1100..1211 CDD:238001 36/221 (16%)
CUB 1216..1330 CDD:238001 34/206 (17%)
CUB 1446..1549 CDD:238001 19/108 (18%)
CUB 1554..1667 CDD:238001 22/130 (17%)
CUB 1792..1899 CDD:238001 25/139 (18%)
CUB 1910..1998 CDD:294042 26/173 (15%)
CUB 2019..2133 CDD:238001 26/136 (19%)
CUB 2140..2242 CDD:238001 10/56 (18%)
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
Svep1XP_038966967.1 VWA 222..396 CDD:395045
Ephrin_rec_like 448..498 CDD:400166
CCP 516..572 CDD:153056
CCP 576..632 CDD:153056
HYR 697..779 CDD:367105
DUF5011 781..859 CDD:413762
Ephrin_rec_like 1141..1188 CDD:400166
Ephrin_rec_like 1195..1242 CDD:400166
Ephrin_rec_like 1249..1296 CDD:400166
EGF 1333..1361 CDD:394967 10/27 (37%)
EGF_CA 1367..1403 CDD:238011 14/40 (35%)
EGF_CA 1405..1441 CDD:238011 13/87 (15%)
EGF_CA 1443..1479 CDD:238011 16/93 (17%)
EGF_CA 1481..1517 CDD:238011 14/42 (33%)
EGF_CA 1519..1555 CDD:238011 11/37 (30%)
PTX 1560..1758 CDD:238086 38/199 (19%)
PHA02927 1780..2036 CDD:222943 64/297 (22%)
EGF_CA 1881..1919 CDD:214542 9/39 (23%)
PHA02817 2036..>2145 CDD:165167 19/115 (17%)
PHA02927 2111..2335 CDD:222943 50/256 (20%)
PHA02927 2230..2455 CDD:222943 46/249 (18%)
PHA02831 2414..>2572 CDD:165176 20/163 (12%)
PHA02927 2537..2745 CDD:222943 31/210 (15%)
Sushi 2796..2847 CDD:395037 14/81 (17%)
PHA02639 2849..>3022 CDD:165022 45/250 (18%)
PHA02927 <2963..3138 CDD:222943 53/253 (21%)
PHA02927 3150..3365 CDD:222943 39/224 (17%)
PHA02927 3370..3602 CDD:222943 50/263 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

Return to query results.
Submit another query.