DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cubn and Tll1

DIOPT Version :9

Sequence 1:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster
Sequence 2:	NP_001099551.1	Gene:	Tll1 / 678743	RGDID:	1306120	Length:	1013	Species:	Rattus norvegicus

Alignment Length:	842	Identity:	204/842 - (24%)
Similarity:	336/842 - (39%)	Gaps:	209/842 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   481 RPTTSGDLFVCQCLP-----------GYRGRLCE---------TRFSSCNGMLSAQSGRLRYPPE 525
            |.|.|..:|:...||           |.|.||.:         .|..:|...|...||.|..|..
  Rat   301 RNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESSGNLSSPGF 365

  Fly   526 GTGYEHNAQCAW--VIRTNESLVVNVTFNSFDVEDSTECRFDWLQINDGRSAAAQIIGRYCGNHL 588
            ..||.....|.|  .:...|.:|:|  |.:.|:..|:.|.:|::::.||....:.::||:||:.:
  Rat   366 PNGYPSYTHCIWRVSVTPGEKIVLN--FTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKV 428

  Fly   589 PHGGNIVSSGNQLYLWFRSDNSTAKEGFDLTWNSMEPQCGGRLNFETHGTLASPGSPGNYPKNRD 653
              .|.:.|:.:::::.|||.::...:||...:.::   |||.:. :..|.:.||..|.:|...::
  Rat   429 --AGVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI---CGGEIR-KNEGQIQSPNYPDDYRPMKE 487

  Fly   654 CRWQLVAPTTKRIKLTFFSLQLEQHANCNFDYVLIKDSISGRE--LAKYCTTGAPAPLLLPTHLA 716
            |.|:::......:.|||.:.::|:|.:|.:|::.::|..|...  :.::|....|..:...::..
  Rat   488 CVWKIMVSEGYHVGLTFQAFEIERHDSCAYDHLEVRDGNSENSPLIGRFCGYDKPEDIRSTSNTL 552

  Fly   717 EIHFHSDAEGSDTGFQLHYSVEERVPGCGGVYTAKEGTISESSTANTEPGGVSCEYEIHLAVGEQ 781
            .:.|.||...:..||..::..|                  |...|..:.||  ||..
  Rat   553 WMKFVSDGTVNKAGFAANFFKE------------------EDECAKADRGG--CEQR-------- 589

  Fly   782 VVIQFARLELDPLDCLEVLDITDEGGSILQEKICGSDAS-RLNPPTFTSEFNRLKIKFYARAGSF 845
                          ||..|      ||..    |..:.. .|.|...:.|
  Rat   590 --------------CLNTL------GSYQ----CACEPGYELGPDRRSCE--------------- 615

  Fly   846 QLNYRMACDYKLNNEQGTITSPGYPNLTRSDRICTYTISTATNTVISLKRIDFQLTNGESDDDDN 910
                 .||...|....||||:||:|.....::.|.:.:...:...||:|...|:|       :.|
  Rat   616 -----AACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVIAPSQYRISVKFEFFEL-------EGN 668

  Fly   911 DECLTTNLRINDGLN--RKILGPYCGKNQPEENFVSETNYLQLHLSTDVDSMGRGFKFEYRALAT 973
            :.|....:.|..||:  .|:.|.:||.:.||. ..|..|.:::...:|.....:|||..:   .:
  Rat   669 EVCKYDYVEIWSGLSSESKLHGKFCGADVPEV-ITSHFNNMRIEFKSDNTVSKKGFKAHF---FS 729

  Fly   974 GNDKC----GG-------------------------------------VHTRSGDHIRLPVHDDS 997
            ..|:|    ||                                     :|:.|| .|..|...|.
  Rat   730 DKDECSKDNGGCQHECVNTMGSYTCQCRNGFVLHENKHDCKEAECEQKIHSPSG-LITSPNWPDK 793

  Fly   998 YAGEATCYWVIMAPANKAIRLHWNSFSLENAVDCIYDYLEIYDSLGAQVNDERSKPLAKYCGNSV 1062
            |.....|.|.|.|.....|:|.:|.|.:|...:|.||:|||:|.     ..|:|..|.:.||:.:
  Rat   794 YPSRKECTWAISAIPGHRIKLAFNEFEVEQHQECAYDHLEIFDG-----QTEKSPILGRLCGSKI 853

  Fly  1063 PEDLLSHSRQLVLKFVSDYSESDGGFDLTYTFEDRAKCGGHI-----------HASSGELTSPEY 1116
            |:.|::...::.::|:||.|....||..|::.|    |||.:           ||..|:
  Rat   854 PDPLMATGNEMFIRFISDASVQRKGFQATHSTE----CGGRLKAERKPKDLYSHAQFGD------ 908

  Fly  1117 PANYSAGLDCDWHLTGTIDHLLEIQVENFELEQSPNCSADYLEVRNGGGTDSPLIGRFCGRDIPA 1181
             .||...|||:|.|.......||:..:.||:|:..:|..||:||.:|..:.:..:|||||...|.
  Rat   909 -NNYPGQLDCEWLLVSEQGSRLELSFQTFEVEEEADCGYDYVEVFDGLNSKAVGLGRFCGSGPPE 972

  Fly  1182 RIPGFSHEMRLILHTDSAINGRGFRLRWRIFAFGCGGSLRSNMGAISSPRYPNSYPNMAHCE 1243
            .|........:..|||..||.:||.:|::        |:|              ||...|.|
  Rat   973 EIYSIGDVALIHFHTDDTINKKGFYIRYK--------SIR--------------YPETMHAE 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	282..322	CDD:214542
		EGF_3	328..366	CDD:289699
		EGF	430..457	CDD:278437
		EGF_CA	469..503	CDD:238011	10/32 (31%)
		CUB	509..622	CDD:238001	31/114 (27%)
		CUB	627..737	CDD:238001	26/111 (23%)
		CUB	744..849	CDD:294042	15/105 (14%)
		CUB	853..970	CDD:238001	32/118 (27%)
		CUB	978..1094	CDD:238001	40/156 (26%)
		CUB	1100..1211	CDD:238001	39/121 (32%)
		CUB	1216..1330	CDD:238001	6/28 (21%)
		CUB	1446..1549	CDD:238001
		CUB	1554..1667	CDD:238001
		CUB	1792..1899	CDD:238001
		CUB	1910..1998	CDD:294042
		CUB	2019..2133	CDD:238001
		CUB	2140..2242	CDD:238001
		CUB	2263..2379	CDD:238001
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:294042
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001
		CUB	3254..3363	CDD:238001
		CUB	3379..3508	CDD:238001
		CUB	3531..3601	CDD:294042
		CUB	3623..3733	CDD:238001
Tll1	NP_001099551.1	ZnMc_BMP1_TLD	148..347	CDD:239808	11/45 (24%)
		Astacin	155..348	CDD:279708	11/46 (24%)
		CUB	349..458	CDD:278839	31/112 (28%)
		CUB	462..571	CDD:278839	26/109 (24%)
		FXa_inhibition	582..614	CDD:291342	12/65 (18%)
		CUB	618..727	CDD:278839	32/116 (28%)
		FXa_inhibition	734..769	CDD:291342	3/34 (9%)
		CUB	774..883	CDD:278839	36/114 (32%)
		CUB	887..1000	CDD:278839	38/119 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910