DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cubn and Pdgfd

DIOPT Version :10

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:NP_076452.1 Gene:Pdgfd / 66018 RGDID:621880 Length:370 Species:Rattus norvegicus


Alignment Length:267 Identity:67/267 - (25%)
Similarity:101/267 - (37%) Gaps:82/267 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1800 SGKFTSPYYPASYPPNIECLWLLEASMGNSLSLTLE-SMDLEKSES--CNRDYLEVREESESGQL 1861
            :|...||.:|.|||.|:...|.|.:.....:.|..: ...||::|:  |..|::||.:.|||..:
  Rat    61 TGHVQSPRFPNSYPRNLLLTWRLHSQEKTRIQLAFDHQFGLEEAENDICRYDFVEVEDVSESSTV 125

  Fly  1862 I-GVYCGN-EVPGVIHSR-GAIWMKFKSDDDNVGE-GFMASYNY------EHHNELNGTEGTIE- 1915
            : |.:||: |:|..|.|| ..|.:.|:|||..|.: ||...|::      |..:|:|....|.. 
  Rat   126 VRGRWCGHKEIPPRITSRTNQIKITFQSDDYFVAKPGFKIYYSFVEDFQPEAASEINWESVTSSF 190

  Fly  1916 ---SPHFPSKFQDPV-----------------------PYSWRITVDKEYVVAISLLYLRDLDQP 1954
               |.|.||.....:                       |.||:..::..|           :|.|
  Rat   191 SGVSYHSPSVMDSTLTADALDKAIAEFDTVEDLLKYFNPASWQDDLENLY-----------MDTP 244

  Fly  1955 HLNFYDGYS--------------DIGARIEVTDPDETI-----ISSTNVVYFT---------SNR 1991
            .   |.|.|              |...|...|..:.::     :..||.|:|.         .|.
  Rat   245 R---YRGRSYHERKSKVDLDRLNDDVKRYSCTPRNHSVNLREELKLTNAVFFPRCLLVQRCGGNC 306

  Fly  1992 GPFKLNW 1998
            |...|||
  Rat   307 GCGTLNW 313

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 cubilin_NTD 21..149 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_CA 324..367 CDD:214542
EGF 430..457 CDD:394967
EGF_CA 469..503 CDD:238011
CUB 509..622 CDD:238001
CUB 627..737 CDD:238001
CUB 744..849 CDD:412131
CUB 853..970 CDD:238001
CUB 978..1094 CDD:238001
CUB 1100..1211 CDD:238001
CUB 1216..1330 CDD:238001
CUB 1446..1549 CDD:238001
CUB 1554..1667 CDD:238001
CUB 1792..1899 CDD:238001 37/105 (35%)
CUB 1910..1998 CDD:412131 24/142 (17%)
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:412131
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:412131
CUB 3623..3733 CDD:238001
PdgfdNP_076452.1 CUB 55..169 CDD:238001 38/107 (36%)
PDGF 270..365 CDD:238079 10/44 (23%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.