DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn and bmp1a

DIOPT Version :9

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:NP_001035126.1 Gene:bmp1a / 572452 ZFINID:ZDB-GENE-060818-1 Length:986 Species:Danio rerio


Alignment Length:872 Identity:213/872 - (24%)
Similarity:349/872 - (40%) Gaps:230/872 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   909 DNDECLTTNLRINDGLNRKILGPYCGKNQPEENFVSETNYLQLHLSTDVDSMGRGFKF------- 966
            |.||.::.   |.|.:            ||.:    |.|:|::. ..:|||:|..:.|       
Zfish   218 DRDEHVSI---IRDNI------------QPGQ----EYNFLKME-PGEVDSLGEVYDFDSIMHYA 262

  Fly   967 ---------------------------EYRALATGN----------DKCGGVHTRSGDHIRLPVH 994
                                       :...|:.|:          .:||.....|..:...|.:
Zfish   263 RNTFSRGIFLDTILPRYDVNGVRPPIGQRTRLSKGDIAQARKLYKCP
RCGDSLQESSGNFSSPGY 327

  Fly   995 DDSYAGEATCYWVIMAPANKAIRLHWNSFSLENAVDCIYDYLEIYDSLGAQVNDERSKPL-AKYC 1058
            .:.|:....|.|.|.....:.|.|::.|..|..:..|.||::||.|...      |..|| .::|
Zfish   328 PNGYSAYMHCIWRISVTPGEKIILNFTSMDLYRSHLCWYDHVEIRDGYW------RKAPLKGRFC 386

  Fly  1059 GNSVPEDLLSHSRQLVLKFVSDYSESDGGFDLTYTFEDRAKCGGHIHASSGELTSPEYPANYSAG 1123
            |:.:|:.::|...:|.::|.|..:....||...|    .|.|||.:...:|::.||.||.:|...
Zfish   387 GDKLPDPIISTDSRLWIEFRSSSNWVGKGFSAVY
----EAICGGEVKKDNGQIQSPNYPDDYRPN 447

  Fly  1124 LDCDWHLTGTIDHLLEIQVENFELEQSPNCSADYLEVRNGGGTDSPLIGRFCGRDIPARIPGFSH 1188
            ..|.|.:|....:.:.:..::||:|:..||:.||||||:|....|||:|||||.|.|..|...|:
Zfish   448 KVCVWKITVAQGYHVGLTFQSFEIERHDNCAYDYLEVRDGNSESSPLLGRFCGYDKPDDIKSSSN 512

  Fly  1189 EMRLILHTDSAINGRGFRLRW----------------------------------------RIFA 1213
            ::.:...:|.::|..||...:                                        |...
Zfish   513 QLWMKFVSDGSVNKAGFAANFFKEMDECSRPDNGRCEQRCVNTLGSYKCACDPGYELAADKRSCE 577

  Fly  1214 FGCGGSLRSNMGAISSPRYPNSYPNMAHCEWRISLHPGSGISLLIEDLELEG--LSN-------- 1268
            ..|||.:....|:|:||.:|..||...:|.|::.......|:||.:..|.||  :|.        
Zfish   578 AACGGFITKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRITLLFDVFETEGNDVSTRFLPLRGV 642

  Fly  1269 CYYDSVKIYTGIKLPNQSPCKVLCKDDDLHNPL--------IQLENNKGTIVFDSDASNTFRGFR 1325
            |.||.|::.:|           |..|..||...        |..:.|...|.|.||.:.:.:||:
Zfish   643 CKYDFVEVRSG-----------LSADSRLHGKFCGAEKPEAITSQYNNMRIEFKSDNTVSKKGFK 696

  Fly  1326 ISY---KANCIRNLTATTGTIESLNYMEPFWETIPINCSWTIRAPKGNRVLVEVSHLARHEQHVP 1387
            ..:   |..|.:.    .|                 .|                       ||..
Zfish   697 AQFFSDKDECSKE----NG-----------------GC-----------------------QHEC 717

  Fly  1388 TATMPGGLYIVDGRNVQEIVTPQAMNISGEVLTVVHNASNVNFQLDYRIDGCMEELRGTFGFFQS 1452
            ..|.  |.|....|             ||.||   |...:     |.:..||...:....|...|
Zfish   718 VNTF--GSYSCQCR-------------SGFVL---HENKH-----DCKEAGCDHVVNSVSGTITS 759

  Fly  1453 PNYPKMYPNNLECYWLITVEQDSAIELTINNIDLEDSPNCTKDALTVSNHKNS-VEVHERHCGST 1516
            ||:|..||:...|.|.::......|::..|.||:|....|..|.:.:.:.::| .:...|:||:.
Zfish   760 PNWPDKYPSKKACTWALSTTPGHRIKIAFNEIDMEPHLECAYDHIEIYDGRDSKAQSLGRYCGTK 824

  Fly  1517 TKLVITSSGHRLHVRFISDNSHNGLGFEATYRTVKATCGGKLTARNGVIESPNYPL----NYPAH 1577
            ....|.|:|:::.:||.||||....||||::   .|.|||:|.|.....:..::..    |||..
Zfish   825 KPQPIISTGNKMFIRFFSDNSVQKKGFEASH---TAECGGRLKAEVKTKDLYSHAQFGDNNYPGA 886

  Fly  1578 SRCEWQVEVSQHH--QIVFEMADLNLESGYDCNWDYLEAYDLTEDDTEGERLFKVCGDETEDDKL 1640
            |.|:|.:...:.:  :::|:..::..|:  ||.:||:|.:|  ..||:..||.:.||....::  
Zfish   887 SDCQWVITAEKGYGVELIFQTFEIEEEA--DCGYDYMELFD--GADTKSPRLGRYCGSGPPEE-- 945

  Fly  1641 LSSSSNMAVVRFISDDSVSKKGFRLHF 1667
            :.|:.:..|::|.|||:::||||.:.:
Zfish   946 IYSAGDSIVIKFHSDDTINKKGFHVRY 972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_3 328..366 CDD:289699
EGF 430..457 CDD:278437
EGF_CA 469..503 CDD:238011
CUB 509..622 CDD:238001
CUB 627..737 CDD:238001
CUB 744..849 CDD:294042
CUB 853..970 CDD:238001 15/94 (16%)
CUB 978..1094 CDD:238001 31/116 (27%)
CUB 1100..1211 CDD:238001 40/150 (27%)
CUB 1216..1330 CDD:238001 36/134 (27%)
CUB 1446..1549 CDD:238001 33/103 (32%)
CUB 1554..1667 CDD:238001 35/118 (30%)
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:294042
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
bmp1aNP_001035126.1 ZnMc_BMP1_TLD 112..309 CDD:239808 17/110 (15%)
Astacin 117..309 CDD:279708 17/110 (15%)
CUB 311..420 CDD:278839 30/114 (26%)
CUB 424..533 CDD:278839 40/108 (37%)
FXa_inhibition 544..576 CDD:291342 1/31 (3%)
CUB 580..699 CDD:278839 36/129 (28%)
FXa_inhibition 706..741 CDD:291342 14/101 (14%)
CUB 746..855 CDD:278839 34/108 (31%)
CUB 859..972 CDD:278839 35/118 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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