DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cubn and bmp1b

DIOPT Version :9

Sequence 1:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster
Sequence 2:	XP_005155463.1	Gene:	bmp1b / 559877	ZFINID:	ZDB-GENE-060818-2	Length:	970	Species:	Danio rerio

Alignment Length:	841	Identity:	209/841 - (24%)
Similarity:	326/841 - (38%)	Gaps:	218/841 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   937 QPEENFVSETNYLQLHLSTDVDSMGRGFKFE---------------------------------- 967
            ||.:    |.|::::. ..||||:|..:.|:
Zfish   225 QPGQ----EYNFIKME-PDDVDSLGEVYDFDSIMHYARNTFSRGIYLDTMLPKYDVDGVRPPIGQ 284

  Fly   968 ---------------YRALATGNDKCGGVHTRSGDHIRLPVHDDSYAGEATCYWVIMAPANKAIR 1017
                           ||.     .:||.....|..:...|...:.||....|.|.|.....:.|.
Zfish   285 RTRLSKGDIAQARKLYRC-----PRCGESLQDSAGNFSSPGFPNGYAAYLHCIWRISVTPGEKIV 344

  Fly  1018 LHWNSFSLENAVDCIYDYLEIYDSLGAQVNDERSKPL-AKYCGNSVPEDLLSHSRQLVLKFVSDY 1081
            |::.|..|..:..|.|||:|:.|..|      ||.|| .:.||:.:||.::|...:|.::|.|..
Zfish   345 LNFTSMDLYRSNLCWYDYVEVRDGYG------RSAPLKGRICGDQLPEAIVSTDSELWIEFRSTS 403

  Fly  1082 SESDGGFDLTYTFEDRAKCGGHIHASSGELTSPEYPANYSAGLDCDWHLTGTIDHLLEIQVENFE 1146
            :....||...|    .|.|||.:...||::.||.||.:|.....|.|.:.......:.:..::||
Zfish   404 NWVGKGFSAVY----EAICGGEVRRDSGQIESPNYPDDYRPNKACIWKIVVPEGFHVGLVFQSFE 464

  Fly  1147 LEQSPNCSADYLEVRNGGGTDSPLIGRFCGRDIPARIPGFSHEMRLILHTDSAINGRGFRL---- 1207
            :|:..||:.||||||:|....|||:|||||.:.|......|:::.:...:|.::|..||..
Zfish   465 IEKHDNCAYDYLEVRDGDSESSPLLGRFCGYEKPDDFKSSSNQLWMKFVSDGSVNKAGFAANFFK 529

  Fly  1208 -------------------------------------RWRIFAFGCGGSLRSNMGAISSPRYPNS 1235
                                                 |....|..|||.:....|:.:||.:|..
Zfish   530 EIDECSRPDNAHCEQRCINTLGSFHCACDPGFELAPDRRSCAAAACGGFISKLNGSFTSPGWPQE 594

  Fly  1236 YPNMAHCEWRISLHPGSGISLLIEDLELEGLSNCYYDSVKIYTGIKLPNQSPCKVLCKDDDLHNP 1300
            ||...:|.|::.......|:||.:..|:||...|.||.|::::|           |..|..||..
Zfish   595 YPPNKNCVWQLIAPVQYRITLLFDAFEMEGNDVCKYDYVEVHSG-----------LSADGKLHGK 648

  Fly  1301 LIQLEN--------NKGTIVFDSDASNTFRGFRISYKAN---CIRNLTATTGTIESLNYMEPFWE 1354
            ....|.        |..::.|.||.:.:.|||:..:.::   |.|.    .|
Zfish   649 FCGTEKPEAITSQLNSMSVEFKSDNTVSKRGFKAQFFSDMDECSRE----NG------------- 696

  Fly  1355 TIPINCSWTIRAPKGNRVLVEVSHLARHEQHVPTATMPGGLYIVDGRNVQEIVTPQAMNISGEVL 1419
                .|                       ||....|.  |.|....|             ||.||
Zfish   697 ----GC-----------------------QHECVNTF--GSYSCQCR-------------SGFVL 719

  Fly  1420 TVVHNASNVNFQLDYRIDGCMEELRGTFGFFQSPNYPKMYPNNLECYWLITVEQDSAIELTINNI 1484
               |:..:     |.:..||.:.:....|...|||:|..||:...|.|.::......|:|....|
Zfish   720 ---HSNKH-----DCKEVGCDQAITSVSGLITSPNWPDKYPSKKACTWTLSTTPGHRIKLAFEEI 776

  Fly  1485 DLEDSPNCTKDALTVSNHKN----SVEVHERHCGSTTKLVITSSGHRLHVRFISDNSHNGLGFEA 1545
            |:|....|..|.|.:.:.:|    ||   .|.|||.....:.||.:.:.:||.||||....||:|
Zfish   777 DMEAHQECAYDHLEIYDGQNGRATSV---GRFCGSKKPSPVISSSNTMFLRFFSDNSVQKRGFKA 838

  Fly  1546 TYRTVKATCGGKLTARNGVIESPNYPL----NYPAHSRCEWQVEVSQHHQIVFEMADLNLESGYD 1606
            ::   .|.|||.|.|.....:..::..    |||..|.|:|.:...:.:.:........:|...|
Zfish   839 SH---SAECGGSLKAEIKTKDLYSHAQFGDNNYPGASDCQWVISAEKGYGVELIFHTFEIEEEAD 900

  Fly  1607 CNWDYLEAYDLTEDDTEGERLFKVCGDETEDDKLLSSSSNMAVVRFISDDSVSKKGFRLHF 1667
            |.:||:|.:|  ..|.:..||.:.||....::  :.|:.:..|::|.|||:::||||.:.:
Zfish   901 CGYDYVELFD--GGDVKAPRLGRYCGSGPPEE--IYSAGDAIVIKFHSDDTINKKGFHVRY 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	282..322	CDD:214542
		EGF_3	328..366	CDD:289699
		EGF	430..457	CDD:278437
		EGF_CA	469..503	CDD:238011
		CUB	509..622	CDD:238001
		CUB	627..737	CDD:238001
		CUB	744..849	CDD:294042
		CUB	853..970	CDD:238001	11/81 (14%)
		CUB	978..1094	CDD:238001	35/116 (30%)
		CUB	1100..1211	CDD:238001	39/151 (26%)
		CUB	1216..1330	CDD:238001	34/121 (28%)
		CUB	1446..1549	CDD:238001	35/106 (33%)
		CUB	1554..1667	CDD:238001	33/116 (28%)
		CUB	1792..1899	CDD:238001
		CUB	1910..1998	CDD:294042
		CUB	2019..2133	CDD:238001
		CUB	2140..2242	CDD:238001
		CUB	2263..2379	CDD:238001
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:294042
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001
		CUB	3254..3363	CDD:238001
		CUB	3379..3508	CDD:238001
		CUB	3531..3601	CDD:294042
		CUB	3623..3733	CDD:238001
bmp1b	XP_005155463.1	ZnMc_BMP1_TLD	109..303	CDD:239808	12/87 (14%)
		Astacin	111..303	CDD:279708	12/87 (14%)
		CUB	305..414	CDD:278839	34/114 (30%)
		CUB	418..527	CDD:278839	38/108 (35%)
		EGF_CA	530..570	CDD:214542	1/39 (3%)
		CUB	575..684	CDD:278839	34/119 (29%)
		FXa_inhibition	691..726	CDD:291342	15/101 (15%)
		CUB	731..840	CDD:278839	36/111 (32%)
		CUB	844..957	CDD:278839	33/116 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910