DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn and zgc:154142

DIOPT Version :10

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:NP_001092710.1 Gene:zgc:154142 / 555481 ZFINID:ZDB-GENE-070615-2 Length:1090 Species:Danio rerio


Alignment Length:1229 Identity:286/1229 - (23%)
Similarity:456/1229 - (37%) Gaps:270/1229 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   509 CNGM--LSAQSGRLRYPPEGTGYEHNAQCAWVIRTNESLVVNVTFNSFDVEDSTECRFDWLQIND 571
            |.|:  |:|.||..........|.:...|||.|....:.||::.|..|.:|||:.|:.|.:.:.|
Zfish    50 CKGLQELTASSGEFSSGNHPNSYNNGMSCAWHITVEANKVVHLWFEHFSIEDSSMCQADSVSLRD 114

  Fly   572 GRSAAAQIIGRYCGNHLPHGGNIVSSGNQLYLWFRSDNSTAKEGFDLTWNSMEP-------QCGG 629
            ....    ||:|||...|..  |||.||.|:::|.:::.....||...:.::.|       ..||
Zfish   115 ELGT----IGKYCGYSTPRA--IVSLGNSLFVYFDTNDRHTDTGFRAVYRAVSPGQTSEIVGAGG 173

  Fly   630 RLNFETHGTLASPGSPG-NYPKNRDCRWQLVAPTTKRIKLTFFSLQLEQHANCNFDYVLIKDSIS 693
            .|..: .|.|.:||.|. ||..:...:|.:..|..::|:|||.:..|... :|. |:|.|.|..|
Zfish   174 VLEGD-RGELLTPGFPALNYESDALYQWMIRVPDGEKIRLTFTAFDLVPE-SCG-DFVDIYDGAS 235

  Fly   694 --GRELAKYCTTGAPAPLLLPTHLAEIHFHSDAEGSDTGFQLHYSVEERVPGCGGVYTAKEGTIS 756
              ..:|.::|....|||:|.......:.|.||:.||..||...|::....|     .|....|.:
Zfish   236 DGAAQLGRFCGNKVPAPVLSSGSSMVVRFKSDSSGSAKGFSATYTLASAPP-----VTTTPPTTT 295

  Fly   757 ESSTANTEPGGVSCEYEIHLAVGEQVVIQFARLELDPLDCLEVLDITDEGGSILQEKICGSDASR 821
            ...|.||                                     ...::.|       |||..  
Zfish   296 AGPTINT-------------------------------------PAPEDSG-------CGSPG-- 314

  Fly   822 LNPPTFTSEFNRLKIKFYARAGSFQLNYRMACDYKLNNEQGTITSPGYPNLTRSDRICTYTISTA 886
                                              ||...:|.|.|..||....::..|::.|:..
Zfish   315 ----------------------------------KLFGRKGQINSEKYPQAYPANLSCSWDITVD 345

  Fly   887 TNTVISLKRIDFQLTNGESDDDDNDECLTTNLRINDGLNRKILGPYCGKNQPEENFVSETNYLQL 951
            ...::.|:..|..:. ||:     .:|....|.::|.|  :.||.:||...|.. .:|.:|.:.:
Zfish   346 EGFLVKLRITDLAIV-GEA-----GQCGKDKLTVSDSL--QSLGTHCGFILPPV-LISVSNKMSV 401

  Fly   952 HLSTDVDSMGRGFKFEYRAL----ATGNDKCGGVHTRSGDHIRLPVHDDSYAGEATCYWVIMAPA 1012
            ...:|.....|||...:.|:    .:....|||...:....|:......:|...:.|.|.|..|.
Zfish   402 RFQSDARLADRGFSATWEAVYPEDLSDIQGCGGFSQQETGVIKSQNWPTNYPANSMCLWTIRTPK 466

  Fly  1013 NKAIRLHWNSFSLENA----VDCIYDYLEIYDSLGAQVNDERSKPLAK----YCGNSVPEDLLSH 1069
            .|.|:|.:..|.:|.|    ..| .|.:.:||.         |||.||    :||..:|..:.|.
Zfish   467 GKTIKLTFTDFDMEEAGILFGQC-NDNVVVYDG---------SKPGAKKYGPFCGTKMPPVIEST 521

  Fly  1070 SRQLVLKFVSDYSESDGGFDLTYTFEDRAKCGGHIHASSGELTSPEYPANYSAGLDCDW-HLTG- 1132
            :.:|||:|.:|:.....||...:|.:......          |.|....|....:..|| ...| 
Zfish   522 TNELVLRFFADFFLEGKGFRAHWTTDSTLPVP----------TEPPVSPNPWDDITIDWPERCGK 576

  Fly  1133 -TIDHLLEIQVENFELEQSPNCSADYLEVRNGGGTDSPLIGRFCGRDIPARIPGFSHEMRLILHT 1196
             |....:..::.|.| ..:|:.....:.::....::.|::|..||..:       .|:..::...
Zfish   577 PTFPPAVNTRIVNGE-PANPHSWPWQVSMQVLRDSEPPMLGHTCGGTL-------IHKNWVLTAA 633

  Fly  1197 DSAINGRGFRLRWRIFAFGCGG--------SLRSNMGAISSPRYPN-SYPNMAHCEWRISLHPGS 1252
            ...|.......||::    |.|        |.......:...|:.. .||.:...|:.|:|....
Zfish   634 HCFIRYADELHRWKM----CLGKHNLTVSESTEQCFNVLGIYRHEGFQYPTVPTVEFDIALVRLD 694

  Fly  1253 GISLLIEDLE----------LEGLSNCYYDSVKIYTGIKLPNQSPCKVLCKDDDLHNPLIQLENN 1307
            |.....|.::          |.|...||.......||    |.:..||....:.:..|::..|  
Zfish   695 GEVTATEHIDFACLPSFEELLPGGKKCYATGWGDETG----NSTAPKVAETLNQVALPVVPYE-- 753

  Fly  1308 KGTIVFDSDASNTFRGFRISYKANCIRNLTATTGTIESLNYMEPFW---ETIPINCSWT------ 1363
                                   .|.|              |:.:|   :|..|.|.:|      
Zfish   754 -----------------------TCKR--------------MDYWWFQVKTSMICCGYTSPDELK 781

  Fly  1364 --IRAPKGNRVLVEVSHLARHEQHVPTATMPGGLYIVDGRNVQEIVTPQAMNISGEVLTVVHNAS 1426
              .:...|..::.:.|..|..|.|..|:..|.|. :.|.:       |.....|...|..:.|..
Zfish   782 SVCQGDSGGPLVCQDSPSAPWEVHGITSFGPIGC-VFDKK-------PSVFTRSSVYLPWIENVI 838

  Fly  1427 NVNFQLDYRIDGC--MEELRGTFGFFQSPNYPKMYPNNLECYWLITVEQDSAIELTINNIDLEDS 1489
            ..:. .|:...||  :::|.||.|...|.::|..|.|...|.|.|.|.....:.|..|:..||::
Zfish   839 RKDI-YDFTTSGCGGLKDLFGTEGTVASMHHPDTYTNRAACQWNIRVPTGKNVYLHFNSFSLEET 902

  Fly  1490 PNCTKDALTVSNHKNSVEVHERHCGSTTKLVITSSGHRLHVRFISDNSHNGLGFEATYRTVKAT- 1553
            ..|..|.:|:|:...|:..   ||.::....:.:...||.:.|.|::.....||.||::.|... 
Zfish   903 ALCLNDKVTLSDSIGSLGT---HCSTSPPRDLVAIDDRLTISFSSNDKIVDTGFSATWKAVDPVD 964

  Fly  1554 ------CGGKLTARNGVIESPNYPLNYPAHSRCEWQVEV---SQHHQIVFEMADLNLESGYDCNW 1609
                  |||..|::.|.::|||:|.:||..:.|.|.:.|   |..| |||...||..........
Zfish   965 IESAVGCGGHFTSQKGELQSPNWPNDYPKQAVCTWTISVPTASGIH-IVFTHFDLQPVGLLGQCV 1028

  Fly  1610 DYLEAYDLTEDDTEGERLFKVCGDETEDDKL-LSSSSNMAVVRFISDDSVSKKGFRLHF 1667
            ||:|..     |..|....|.|    |.:.| |:.....|.:||:|:|:..||||:.|:
Zfish  1029 DYVEVL-----DAAGTSQGKFC----ESEPLSLTVKGVKATIRFLSNDANQKKGFQGHW 1078

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 cubilin_NTD 21..149 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_CA 324..367 CDD:214542
EGF 430..457 CDD:394967
EGF_CA 469..503 CDD:238011
CUB 509..622 CDD:238001 36/114 (32%)
CUB 627..737 CDD:238001 37/112 (33%)
CUB 744..849 CDD:412131 9/104 (9%)
CUB 853..970 CDD:238001 28/116 (24%)
CUB 978..1094 CDD:238001 35/123 (28%)
CUB 1100..1211 CDD:238001 18/113 (16%)
CUB 1216..1330 CDD:238001 22/132 (17%)
CUB 1446..1549 CDD:238001 29/102 (28%)
CUB 1554..1667 CDD:238001 40/116 (34%)
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:412131
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:412131
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:412131
CUB 3623..3733 CDD:238001
zgc:154142NP_001092710.1 CUB 57..159 CDD:238001 33/107 (31%)
CUB 172..280 CDD:238001 36/110 (33%)
CUB 310..420 CDD:238001 31/154 (20%)
CUB 432..546 CDD:238001 35/123 (28%)
Tryp_SPc 587..837 CDD:238113 53/312 (17%)
CUB 850..959 CDD:238001 32/111 (29%)
CUB 971..1080 CDD:238001 41/118 (35%)
Blue background indicates that the domain is not in the aligned region.

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