Protein Alignment Cubn and mep1a

DIOPT Version :10

• Sequence 1: NP_727348.2
• Gene: Cubn / 326235
• FlyBaseID: FBgn0052702
• Length: 3750
• Species: Drosophila melanogaster
• Sequence 2: NP_001015767.1
• Gene: mep1a / 548484
• XenbaseID: XB-GENE-921661
• Length: 704
• Species: Xenopus tropicalis
• Alignment Length: 656
• Identity: 131/656 - (19%)
• Similarity: 213/656 - (32%)
• Gaps: 221/656 - (33%)

  Fly  3148 DNTLPPGS-----DCYWNLTAPAGY------KFNIKFLF------------IDFEANSNCAYDG- 3188
            |..|||.:     |.|:..:.|..|      ..|.|.:.            :||:     .|:|
 Frog    58 DIVLPPRARNALLDDYYRWSFPIPYILADNLDLNAKSVILKAFEMFRLKSCVDFK-----PYEGE 117

  Fly  3189 -----VEVFSGPIPDERYRWGRFCGRINEDLPL---ISIPQ--------ERGIIHSFSDDRDPSR 3237
                 .:.|.|            |..:..||.:   :||.:        |..|:|:.....:.||
 Frog   118 PTYIHFQKFGG------------CWSMVGDLKVGQNLSIGERCDYKAIVEHEILHALGFYHEQSR 170

  Fly  3238 GFRALVRVMPNCDEKI-----SLNGSSRYVYSKFNNAGGYQNDLDC-----------QIVFRVNP 3286
            ..|         |:.:     .:.....:.::|:.:  .|..||:.           .:.|..||
 Frog   171 SDR---------DDYVKIWWEEITSGMEHNFNKYED--NYITDLNTPYDYESVMHYGPLSFNKNP 224

  Fly  3287 D-QQISVEFSNFHVQDTDGCRSDYVELR----------DGGGTFAD--------IIGRFCGQN-- 3330
            | ..|:.:...|:  |..|.|.|:.|:.          ....|..|        |.|...|.|
 Frog   225 DVPTITAKIEAFN--DIIGQRLDFSEIDLERLNRMYNCTASHTLLDQCTFEYINICGMVQGTNDN 287

  Fly  3331 --------QPPTLRTTRHTL---------YMRFVT-DNKVTDTGF-----------QVTINAIPR 3366
                    ||   .:..|||         :|.|.| ...:..|..           :..:....:
 Frog   288 ADWVHEMSQP---GSEDHTLAGGCRDAGYFMHFDTHSGPIGSTALLESRILYPKRSEQCLQFFYK 349

  Fly  3367 LCGSSEITL-----SADGTKEVTINSPARTPGGNYPNGVSCFWKIKGDSL---LRVQFVNFDLHG 3423
            :.|||:..|     :.||...|.......|..|:....    |||...:|   .:.::|...:||
 Frog   350 MDGSSQDRLVIWLKTDDGAGNVRKMRKLHTIYGDSDRS----WKIAHVTLNANKKFRYVFQGIHG 410

  Fly  3424 PNQ--NGSCVDDYL--------KIYNSED-APLLEQGLGTDLVFNGQTSSKNGFGFATEHVYCGN 3477
            .|:  .|..:||..        .::..:| :.:||.....|.:.:....|..|:.:..
 Frog   411 NNKTSGGISLDDISLTETPCPNTVWRVKDFSKILESTTKGDRIMSNPFYSPEGYAYGI------- 468

  Fly  3478 VKPDIY-YGRSSEVYLKFRSKGLEQHGGFQLQV----ALNSNRER------HYDGLQGRVHLSQS 3531
               .|| :|::|..|:.:.........|....|    ||  ||:.      ....:|.|:..|:|
 Frog   469 ---TIYPHGQASSPYVNYTGISFHMISGEDDDVMEWPAL--NRQAIITVLDQDPNVQHRMSSSRS 528

  Fly  3532 AD--CNIIIRAPPNYTLSLYYTELIFGTYD--CEMENLEVFDRTNRSLQRVCSFVDMGKSLFSNA 3592
            ..  .:.||.:..|  :|.:....:.||:|  |:..      ||          .|.|.|.|.:.
 Frog   529 FTTLSSQIIESMNN--ISRWERPSLIGTFDPTCDCY------RT----------PDFGWSTFISH 575

  Fly  3593 NEL--RLQMKTGSYLTSL---DLTYL---------ASPVEKGPGCGGQFYNTEGIFSNPFYPNNV 3643
            ::|  |..:|....:..|   |||:|         |:|.||.........:.:.:..||..||..
 Frog   576 SQLHRRNFLKNDDLILFLEFEDLTFLSKTEVPIRPAAPREKEVVLERSRRSPQNVDENPCDPNPC 640

  Fly  3644 RNNSEC 3649
            .|...|
 Frog   641 LNGGAC 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn	NP_727348.2	cubilin_NTD	21..149	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	282..322	CDD:214542
		EGF_CA	324..367	CDD:214542
		EGF	430..457	CDD:394967
		EGF_CA	469..503	CDD:238011
		CUB	509..622	CDD:238001
		CUB	627..737	CDD:238001
		CUB	744..849	CDD:412131
		CUB	853..970	CDD:238001
		CUB	978..1094	CDD:238001
		CUB	1100..1211	CDD:238001
		CUB	1216..1330	CDD:238001
		CUB	1446..1549	CDD:238001
		CUB	1554..1667	CDD:238001
		CUB	1792..1899	CDD:238001
		CUB	1910..1998	CDD:412131
		CUB	2019..2133	CDD:238001
		CUB	2140..2242	CDD:238001
		CUB	2263..2379	CDD:238001
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:412131
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001	26/132 (20%)
		CUB	3254..3363	CDD:238001	30/169 (18%)
		CUB	3379..3508	CDD:238001	27/143 (19%)
		CUB	3531..3601	CDD:412131	17/75 (23%)
		CUB	3623..3733	CDD:238001	6/27 (22%)
mep1a	NP_001015767.1	ZnMc_meprin	31..260	CDD:239809	43/231 (19%)
		MAM	270..431	CDD:459878	33/167 (20%)
		MATH_Meprin_Alpha	430..596	CDD:239752	39/195 (20%)
		EGF	635..>658	CDD:394967	4/12 (33%)