DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cubn and ASTL

DIOPT Version :10

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:XP_011509507.1 Gene:ASTL / 431705 HGNCID:31704 Length:436 Species:Homo sapiens


Alignment Length:488 Identity:103/488 - (21%)
Similarity:141/488 - (28%) Gaps:198/488 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   396 SCFLISGTTSCRCPMGMVGTGYGPNGCVNGTTTNCKENPCLNGGICLFAGPSNYTC--LC----P 454
            ||.|:|       |:|      .|..||      |   |||:|...:...|...:|  .|    |
Human     2 SCCLVS-------PVG------APGICV------C---PCLSGPGVILGAPLASSCAGACGTSFP 44

  Fly   455 IGFRPPICEPQPSPCDQHPCKNGGRCRPTTSGDLFVCQCLPGYRGRLCETRFSSCNGMLSAQSGR 519
            .|..|.  ..|.|.....|..|.|.....|....|:.:      |.:..   .|...:|||.|. 
Human    45 DGLTPE--GTQASGDKDIPAINQGLILEETPESSFLIE------GDIIR---PSPFRLLSATSN- 97

  Fly   520 LRYPPEGTGYEHNAQCAWVIRTNESLVVNVTF---NSFD-------------VEDSTECRF---- 564
             ::|..|:|                 ||.|.|   :.:|             .|.||..||    
Human    98 -KWPMGGSG-----------------VVEVPFLLSSKYDEPSRQVILEALAEFERSTCIRFVTYQ 144

  Fly   565 ---DWLQI--------NDGRSAAAQIIGRYCGNHLPHGGNIV--SSGNQLYLWFRSDNSTAKEGF 616
               |::.|        :.|||...|::. .....|..|..||  ...:.|..|.....:......
Human   145 DQRDFISIIPMYGCFSSVGRSGGMQVVS-LAPTCLQKGRGIVLHELMHVLGFWHEHTRADRDRYI 208

  Fly   617 DLTWNSMEP---------QCG--------------GRLNFETHG--TLASPGSPGNYPKNRDCRW 656
            .:.||.:.|         |..              |||.|...|  |:....:|..:...   ||
Human   209 RVNWNEILPGFEINFIKSQSSNMLTPYDYSSVMHYGRLAFSRRGLPTITPLWAPSVHIGQ---RW 270

  Fly   657 QLVAPTTKRIKLTFFSLQL-------------EQHANCNFDYVLIKDSISGRELAKYCTTGAPAP 708
            .|.|....|:      |:|             ..||:.           :||       :.|||.
Human   271 NLSASDITRV------LKLYGCSPSGPRPRGRGSHAHS-----------TGR-------SPAPAS 311

  Fly   709 LLLPTHLAEIHFHS---DAEGSDTGFQ--------------------------------LHYSVE 738
            |.|...|..:...|   |..||..|.|                                |..|..
Human   312 LSLQRLLEALSAESRSPDPSGSSAGGQPVPAGPGESPHGWESPALKKLSAEASARQPQTLASSPR 376

  Fly   739 ERVPGCGGVYTAKE-----GTISESSTANTEPG 766
            .| ||.|....|:|     |..::.:..::|.|
Human   377 SR-PGAGAPGVAQEQSWLAGVSTKPTVPSSEAG 408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 cubilin_NTD 21..149 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_CA 324..367 CDD:214542
EGF 430..457 CDD:394967 9/32 (28%)
EGF_CA 469..503 CDD:238011 6/33 (18%)
CUB 509..622 CDD:238001 30/145 (21%)
CUB 627..737 CDD:238001 31/173 (18%)
CUB 744..849 CDD:412131 6/28 (21%)
CUB 853..970 CDD:238001
CUB 978..1094 CDD:238001
CUB 1100..1211 CDD:238001
CUB 1216..1330 CDD:238001
CUB 1446..1549 CDD:238001
CUB 1554..1667 CDD:238001
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:412131
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:412131
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:412131
CUB 3623..3733 CDD:238001
ASTLXP_011509507.1 ZnMc 105..286 CDD:469599 41/207 (20%)
PHA03307 273..>428 CDD:223039 31/161 (19%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.