DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn and tok

DIOPT Version :9

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:NP_001287510.1 Gene:tok / 42944 FlyBaseID:FBgn0004885 Length:1464 Species:Drosophila melanogaster


Alignment Length:1692 Identity:356/1692 - (21%)
Similarity:567/1692 - (33%) Gaps:547/1692 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   470 DQHPCKNGGRCRPTTSGDLFVCQCLP-GYRGRLC--------ETRFSSCNGMLSAQSGRLRYPPE 525
            |..|||.||     ..||:    .|| |..|.:.        |........:|:.....:..||.
  Fly   146 DMDPCKAGG-----FMGDI----ALPEGDSGPVVAHTPIDDEEQERQEVEQLLADSPSPVHDPPS 201

  Fly   526 GTGYEHNAQCAWVIRTNESLVVNVTFNSFDVED-STECRFDWLQINDGRSAAAQIIGRYCGNHLP 589
            .:|..::....:          |.|| ..|:|. ..|...:.||:.:  .....||.:  ...||
  Fly   202 VSGAANSGPTKF----------NATF-QLDLEKLKQEVYHEGLQVEE--EGLTDIIRK--KTKLP 251

  Fly   590 HGGNIVSSGNQLYLWFRSDNSTAKEGFDLTWNSMEPQCGGRLNFETHGTLASPGSPGNYPKNRDC 654
            ..|.:.....|.....:|.|...|.|.:                          ||.:|.:....
  Fly   252 SSGPVNLKAGQSQSQSQSANEPVKPGSE--------------------------SPSDYAQASSY 290

  Fly   655 RWQLVAPTTKRI------KLTF------FSLQLEQ-HANCN-----FDYVLIKDSISGRELAKYC 701
            :.:::.|:.:||      :||.      ||.:.:. |.|.:     .|...|:|. ||.   .:.
  Fly   291 KNEVLPPSEQRIHTDKPARLTLAEIGPKFSNKTQSLHRNVDTRKIQSDNKDIEDD-SGN---NFV 351

  Fly   702 TTGAPAPLLLPTHLAE-----IHFHSDAEGSDTGFQLHYSVE---ERVPGCGGVYTAKEGTISES 758
            ....|:. ::||.|.|     .|.:|:|.|:  |.||...|:   .|     ||...:.....:.
  Fly   352 AERRPSQ-IVPTSLPEQRSTPAHVYSNAGGN--GMQLDDEVDFLHSR-----GVVRRRHRRGPKQ 408

  Fly   759 STANTEPGGVSCEYEIHLAVGEQVVIQFARLELD-PLDCLEVLDITDEGGSILQEKICGSDASRL 822
            ..:|.           ||.  .:|.:|..|.||. |:  :|............|.        |.
  Fly   409 RRSNQ-----------HLE--HEVKLQRLREELSRPV--IEAHHHQSHHQKQAQH--------RQ 450

  Fly   823 NPPTFTSEFNRLKIKFYARAGSFQLNYRMACDYKLNNEQGTITSPGYPNLTRSDRICTYTISTAT 887
            :..:...:.:|.:.:.:.|.|.....|       :|:      ||  |...:|.:....::.   
  Fly   451 HHQSHHRKKHRRQQQHHRRRGQSTTQY-------VNH------SP--PGFNQSQQAQQQSVP--- 497

  Fly   888 NTVISLKRIDFQLTNGESDDDDND------ECLTTNL-RIND--GLNRKILGPYCG--------- 934
                     :..|...|:..|:..      ..:|... ||.|  .:..:|.|.:.|         
  Fly   498 ---------EMDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLA 553

  Fly   935 ----KNQPEENFVS-----ETNYLQLHL-----STDVDSMGRGFKFEYRALATGNDKCGGVHTRS 985
                :|.....||.     ..||:...:     .:.|...|.|    .:|::.|         |:
  Fly   554 MRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNG----PQAISIG---------RN 605

  Fly   986 GDHIRLPVHDDSYAGEATCYW-----------VIMAPAN--KAIRLHWNSFSLENAVDCI---YD 1034
            .|...:.||:   .|....:|           |::...|  |....::|..| .:.||.:   ||
  Fly   606 CDKFGIVVHE---LGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLS-PDEVDSLGMAYD 666

  Fly  1035 YLEIYDSLGAQVNDERSKPLAKYCGNSVPEDLLSHSR----QLVLKFVSDYSESDGGFDLTYTFE 1095
                |||:.....:..||  ..|....:|.::....|    |.:.....|.:::    :|.|.. 
  Fly   667 ----YDSIMHYARNTFSK--GTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQA----NLLYKC- 720

  Fly  1096 DRAKCGGHIHASSGELTSPEYPANYSAGL------DCDWHLTGTIDHLLEIQVENFELEQSPNCS 1154
              .|||.....|||...|   |::|:||.      .|:|.:|.|....:|:::||..:.:|.||.
  Fly   721 --PKCGRTFQESSGIFAS---PSHYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCE 780

  Fly  1155 ADYLEVRNGGGTDSPLIGRFCGRDIPARIPGFSHEMRLILHTDSAING-RGFRLRWRIFAFGCGG 1218
            .||||:|:|....|||||||||:.....|...|..|.|.......|.| |||:..:.:.   |||
  Fly   781 TDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVV---CGG 842

  Fly  1219 SLRSN--MGAISSPRYPNSYPNMAHCEWRISLHPGSGISLLIEDLELEGLSNCYYDSVKIYTGIK 1281
            .|..:  :|.:.||.||..|.....|.|:|::.....::|..:..|:|...:|.||.|::..|  
  Fly   843 ELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDG-- 905

  Fly  1282 LPNQSPCKVLCKDDDLHNPLIQLENNKGTIVFDSDASNTFRGFRISYKANCIRNLTATTGTIESL 1346
             |.|..            |||                    |....||.                
  Fly   906 -PGQDA------------PLI--------------------GVFCGYKP---------------- 921

  Fly  1347 NYMEPFWETIPINCSWTIRAPKGNRVLVE-VSHLARHEQHVPTATMPGGLYIVDGRNVQEIVTPQ 1410
                      |.|..     ..||.:.|: ||         .|:....|...|..:.|.|..| |
  Fly   922 ----------PPNMK-----SSGNSMYVKFVS---------DTSVQKAGFSAVFMKEVDECET-Q 961

  Fly  1411 AMNISGEVLTVVHN---ASNVNFQLDYRIDGCMEELRGTF----GFFQSPNYPKMYPNNLECYWL 1468
            ......|.:..:..   :..:.|:|......|.:...|..    |...||::|:|||...||.|.
  Fly   962 NHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWE 1026

  Fly  1469 ITVEQDSAIELTINNIDLE----DSPNCTKDALTVSNH--KNSVEVHERHCGSTTKLVITSSGHR 1527
            |.......|.|...:.|||    ...:|..|::||.:.  :|.::.....|||:.....||..:.
  Fly  1027 IVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNA 1091

  Fly  1528 LHVRFISDNSHNGLGFEATYRTVKATC----GG-------------------------------- 1556
            |.:.|.||.|....||.|.:.|....|    ||                                
  Fly  1092 LRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSMHENGHDCKEG 1156

  Fly  1557 ----KLTARNGVIESPNYPLNYPAHSRCEWQVEVSQHHQIVFEMADLNLESGYDCNWDYLEAYDL 1617
                :::|..|.|.|||||.:||.::.|.|....:..|:|.....:.::||..:|.:|.:..|| 
  Fly  1157 ECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYD- 1220

  Fly  1618 TEDDTEGERLFKVCGDETEDDKLLSSSSNMAVVRFISDDSVSKKGFRLHFHESCGQTIIVDETMF 1682
             .:......|.:.|||:....  :||:||...:...:|.:..|.||......:||          
  Fly  1221 -GESESSSVLGRFCGDKIPFP--ISSTSNQMYMVLKTDKNKQKNGFTASHSTACG---------- 1272

  Fly  1683 DYIQMSRQAARNESCLWVFQAVEPNKRIIFTPTHVKLREDANQQYPTEGDCLNVGVKIYEGTEPQ 1747
            .|::.:.|                                                         
  Fly  1273 GYLRATSQ--------------------------------------------------------- 1280

  Fly  1748 GTPRLKFCRSHPPALISNGQALTVSVPLQLVEEFQGHYMTMDTSCGSIYNALSGKFTSPYYPASY 1812
                                          |::|..|                .:|.:    ..|
  Fly  1281 ------------------------------VQQFYSH----------------ARFGN----QDY 1295

  Fly  1813 PPNIECLWLLEASMGNSLSLTLESMDLEKSESCNRDYLEVREE-----SESGQLIGVYCGNEVPG 1872
            ...::|.|.:.|...:.:.|...:.|:|.||:|..||::|..:     .:.|.:.|.||||.:|.
  Fly  1296 DDGMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQ 1360

  Fly  1873 VIHS-RGAIWMKFKSDDDNVGEGFMASY-------NYEHHNELNGTEGTIESPHFPSKFQDPVPY 1929
            .|:| ..::.::||:|.....:||.|||       .|:|.:|      .:|: .:.|:...|.|.
  Fly  1361 DINSMTHSLLVRFKTDGSVPMKGFSASYVAVPNSGEYDHSDE------DVEN-SYSSEMVTPFPG 1418

  Fly  1930 SWRITVDKEYVVAISLLYLRDLDQPHLNFYDGYSDIGARIEVTDPDETIISSTNVVYFTSNRGPF 1994
            |            :..:|:.|..:.    .|.|||              .|...:|:....||.:
  Fly  1419 S------------LKSIYIEDTQEE----TDEYSD--------------FSGNQLVFNGQYRGRY 1453

  Fly  1995 KL 1996
            .|
  Fly  1454 SL 1455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_3 328..366 CDD:289699
EGF 430..457 CDD:278437
EGF_CA 469..503 CDD:238011 12/41 (29%)
CUB 509..622 CDD:238001 22/113 (19%)
CUB 627..737 CDD:238001 29/132 (22%)
CUB 744..849 CDD:294042 17/105 (16%)
CUB 853..970 CDD:238001 23/148 (16%)
CUB 978..1094 CDD:238001 27/135 (20%)
CUB 1100..1211 CDD:238001 44/117 (38%)
CUB 1216..1330 CDD:238001 28/115 (24%)
CUB 1446..1549 CDD:238001 34/112 (30%)
CUB 1554..1667 CDD:238001 35/152 (23%)
CUB 1792..1899 CDD:238001 29/112 (26%)
CUB 1910..1998 CDD:294042 16/87 (18%)
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
tokNP_001287510.1 ZnMc_BMP1_TLD 520..721 CDD:239808 44/230 (19%)
Astacin 527..721 CDD:279708 43/223 (19%)
CUB 723..836 CDD:294042 44/115 (38%)
CUB 840..951 CDD:278839 38/185 (21%)
FXa_inhibition 958..993 CDD:291342 5/35 (14%)
CUB 997..1111 CDD:278839 35/113 (31%)
FXa_inhibition 1118..1153 CDD:291342 3/34 (9%)
CUB 1158..1267 CDD:278839 32/112 (29%)
CUB 1271..1390 CDD:238001 38/235 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45444843
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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