DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cubn and Nrx-1

DIOPT Version :9

Sequence 1:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster
Sequence 2:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster

Alignment Length:	1697	Identity:	309/1697 - (18%)
Similarity:	468/1697 - (27%)	Gaps:	727/1697 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RLLLCWTLLAIITDTWPIAEGFVNSPKIISKDGNLIFESGANRNISFR-----LSGNSRLTINEE 67
            |:|:...||.      .:|..||........||:      .|...:||     |:|...|....|
  Fly    83 RVLIVSALLV------SLAASFVTLSAGFQLDGS------QNSFYTFRKWYTGLNGTLELEFKTE 135

  Fly    68 --------------LDVMELLLATSGSKKR--SGGKDDDFVDARELAD-------QLADFNRRAF 109
                          .|..||.|.....:.|  .||........|||.|       .|.:..:.:.
  Fly   136 QPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRNDEQTSL 200

  Fly   110 GANGLSAMLRVQQNRTRG-------------------------SMALLRR----FQTRLR-ALEN 144
            ..:|:|     ||..|:|                         .:|||..    |:.|.| |:.|
  Fly   201 IVDGVS-----QQRSTKGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRN 260

  Fly   145 RV-------------DRMKTDLEANS--CASG-------------------------PCENGGTC 169
            .|             .:.:.|::...  |..|                         ||::||.|
  Fly   261 LVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGIC 325

  Fly   170 YNTYTGFRCQCRS-AFEGTKCEMDVNECALYEGTDLGCQNGGQCQNHFGTYSCLCQPGWHGMHCT 233
            .:|.:|..|:||: .::|..||   .|.|..|.|..|.|        |.:|
  Fly   326 ISTDSGPICECRNLEYDGQYCE---KEKAPSEATFRGTQ--------FLSY-------------- 365

  Fly   234 QRKADCSQSSAWELCGHGSCVPSADDA--GYRCICEPGWKTNGLTPICGEDVDECSDSAAHKPCS 296
                |..|:.|       ..:.||.||  .|....:|    |||....|.              .
  Fly   366 ----DLGQTGA-------EPIVSAQDAISFYFRTRQP----NGLLFYTGH--------------G 401

  Fly   297 TSCINLPGSFTCAPCPAGLTGNGVSC-------------------------------RDLDECQT 330
            |..:||           .|...|||.                               |.:.|..:
  Fly   402 TDYLNL-----------ALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISS 455

  Fly   331 NNGGCSLSPKVDCINTYGSYHCGECPVGWTGDGRKCERSPQDIDIPAGQTPRTCPAGNNPCYPTA 395
            ....|.|...||.:.|..|:..|:..:                                   .::
  Fly   456 ITSFCRLVTVVDDVYTDHSHIAGKFTM-----------------------------------LSS 485

  Fly   396 SCFLISGTTSCRCPMGMVGTGYGPN--GCV-----NGTTTNCKENPCLNGGICLFAGPSNYTCLC 453
            |...:.|..:   |..::|.....|  ||:     :..|.|.........|..|.....|....|
  Fly   486 SRVYVGGAVN---PRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQC 547

  Fly   454 PIGFRPPICEPQPSPCDQHPCKNGGRCRPTTSGDLFVCQCLPGYRGRLCETRFSSCNGMLSAQSG 518
            |.|      :||.               |.|                            .:.:..
  Fly   548 PSG------DPQD---------------PVT----------------------------FTTRES 563

  Fly   519 RLRYPPEGTGYEHNAQCAWVIRTNE--SLVVNVTFNSFDVEDSTECRFDWLQINDGRSAAAQIIG 581
            .|..||..||.:  :..::..||.|  .::|..|       .|.:.|     ..:....|.:::.
  Fly   564 HLVLPPWETGKQ--SSISFKFRTKEPNGIIVLAT-------GSKQPR-----AKNPVLIAIELLN 614

  Fly   582 RYCGNHLPHGGNI---------VSSGNQLYLWFRSDNSTAKEGFDLTWNSME-PQCGGRLNFETH 636
            .:...||..|...         |..|:...|..|.:...||...|..||... |..|..|..:.|
  Fly   615 GHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGH 679

  Fly   637 GTLASPGSPGNYPKNRDCRWQLVAPTTKRIKLTFFSLQLEQHANCNFDYVLIKDSISGR--ELAK 699
            ..|...|     |......|. .|..|..::..|        ..|..|.||     ||:  ::|.
  Fly   680 MYLGGVG-----PAYNSVSWP-AAIWTATLRQGF--------VGCLRDLVL-----SGKAIDIAA 725

  Fly   700 YCTTGAPAPLLLPTHLAEIHFHSDAEGSDTGFQLHYSVEERVPGCGGVYTAKEGTISESSTANTE 764
            :.                                      ||                ..:|:.:
  Fly   726 FA--------------------------------------RV----------------QDSASVK 736

  Fly   765 PGGVSCEYEIHLAVGEQVVIQFARLELDPLDCLEVLDITDEGGSILQ---EKICGSDASRLNPPT 826
            |   ||..:.::..|.              .||       .||:.|:   ..||...|:....||
  Fly   737 P---SCHVQANVCNGN--------------PCL-------NGGTCLEGWNRPICDCSATLYGGPT 777

  Fly   827 FTSEFNRLKIKFYARAGSFQLNYRMACDYKLNNEQGTITS-------------PGYPNLTRS--- 875
            ...|...|         :|..:..|.  ..|.|.|||.|.             .|...||.:
  Fly   778 CGRELATL---------AFNGSQHMT--IWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESN 831

  Fly   876 --DRICTYTISTATNTVISLKRIDFQLTNGESDDDDND------ECLTTNLRIN-DGLNRKILGP 931
              ||:....::......:.|...:..|..|:|..:||:      ....:|||:. ||.
  Fly   832 SPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGA------- 889

  Fly   932 YCGKNQPEENFVSETNYLQLHLSTDVDSMGRGFKFEYRALATGNDKCGGVHTRSGDHIRLPVHDD 996
                 .|....:|||            .:||....|.|::..|    |..|..  :.|::.....
  Fly   890 -----PPVRGMLSET------------ILGRHSTMEIRSVHLG----GLFHAE--EEIQMTSTMP 931

  Fly   997 SYAGEATCYWVIMAPANKAIRLHWNSFSLENAVDCIYDYLEIYDSLGAQ---------------V 1046
            ::.|:                       ::..|.....||:|..|||.:               |
  Fly   932 NFVGQ-----------------------MQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFV 973

  Fly  1047 NDERSKPL--------AKYCG-------NSV----------PEDLLSHSRQLVLKFVS------- 1079
            |....:|.        ..|.|       ||:          |..||..:......||:
  Fly   974 NSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGH 1038

  Fly  1080 -DYSESDGGFDL---TYTFEDRAKCGGHIHASSGELTSPEYPANYSAGLDCDWHLT-----GTID 1135
             .|:     |||   ..|..|:::    ||.:                 |..||..     |...
  Fly  1039 IHYT-----FDLGDGPVTMRDKSR----IHMN-----------------DNRWHQVSIRRPGPKT 1077

  Fly  1136 HLLEIQVENFELEQ--SPNCSADYLEVRNGGGTDSPLIGRFCGRDIPARI---PGFSHEMRLI-- 1193
            |.|.:. ::||:..  ..|...:...:...||....:..:     :||.|   .||...:..:
  Fly  1078 HTLTVD-DSFEIISLTGNNMHLELAGILYIGGVFKDMYSK-----LPASISSRSGFEGCLASLDL 1136

  Fly  1194 ------LHTDSAINGRGFRLRWRIFAFGCGGSLRSNMGAISSPRYPNSYPNMAHC--EWRISLHP 1250
                  |.:|:.:..       .:...||.|..:.:.         |:..|..:|  :|....
  Fly  1137 GDASPSLTSDAVVPS-------SLVVSGCEGPTKCSQ---------NACANRGNCVQQWNAYA-- 1183

  Fly  1251 GSGISLLIEDLELEGLSNCYYDSVKIYTGIKLPNQSPCKVLCKDDDLHNPLIQLENNKGTIVF-- 1313
                              |..|... |||   |.       |.|:.:   ..:..||||.:.:
  Fly  1184 ------------------CECDMTS-YTG---PT-------CYDESI---AYEFGNNKGMVQYTF 1216

  Fly  1314 ------DSDASNTFRGFRISYKANCI--RNLTATTGTIESLNYME--------------PFWETI 1356
                  |::..|...|| |:.:.:.:  |..:|||.....|..:|              |..|.
  Fly  1217 PENAQADTEEDNIALGF-ITTRPDAVLLRVESATTQDYMELEIVEGNIFMVYNIGSVDLPLGEI- 1279

  Fly  1357 PINCSWTIRAPKGNRVLVEVSHLARHEQHVPTATMPGGLYIVDGRNVQEIVTPQAMNISGEVLTV 1421
                        |.:|.....|:.|.::....||:.     :|..|||.: |||:.:     .||
  Fly  1280 ------------GTKVNDNAYHVVRFQRKGGNATLQ-----LDDYNVQAL-TPQSHH-----STV 1321

  Fly  1422 VHNASNV 1428
            .:..|||
  Fly  1322 FNTMSNV 1328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011	13/61 (21%)
		EGF_CA	192..233	CDD:238011	8/40 (20%)
		EGF_CA	282..322	CDD:214542	6/39 (15%)
		EGF_3	328..366	CDD:289699	7/37 (19%)
		EGF	430..457	CDD:278437	5/26 (19%)
		EGF_CA	469..503	CDD:238011	2/33 (6%)
		CUB	509..622	CDD:238001	24/123 (20%)
		CUB	627..737	CDD:238001	17/111 (15%)
		CUB	744..849	CDD:294042	18/107 (17%)
		CUB	853..970	CDD:238001	29/141 (21%)
		CUB	978..1094	CDD:238001	27/166 (16%)
		CUB	1100..1211	CDD:238001	20/128 (16%)
		CUB	1216..1330	CDD:238001	23/123 (19%)
		CUB	1446..1549	CDD:238001
		CUB	1554..1667	CDD:238001
		CUB	1792..1899	CDD:238001
		CUB	1910..1998	CDD:294042
		CUB	2019..2133	CDD:238001
		CUB	2140..2242	CDD:238001
		CUB	2263..2379	CDD:238001
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:294042
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001
		CUB	3254..3363	CDD:238001
		CUB	3379..3508	CDD:238001
		CUB	3531..3601	CDD:294042
		CUB	3623..3733	CDD:238001
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	33/163 (20%)
		EGF_CA	311..347	CDD:238011	11/35 (31%)
		Laminin_G_2	386..517	CDD:280389	28/197 (14%)
		LamG	555..716	CDD:238058	40/216 (19%)
		EGF	746..777	CDD:278437	9/51 (18%)
		Laminin_G_2	814..945	CDD:280389	30/183 (16%)
		LamG	988..1136	CDD:238058	33/179 (18%)
		EGF	1164..1195	CDD:278437	9/63 (14%)
		Laminin_G_2	1233..1356	CDD:280389	28/121 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444892
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930