DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn and Nrx-IV

DIOPT Version :9

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:NP_524034.2 Gene:Nrx-IV / 39387 FlyBaseID:FBgn0013997 Length:1284 Species:Drosophila melanogaster


Alignment Length:784 Identity:153/784 - (19%)
Similarity:232/784 - (29%) Gaps:300/784 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 SFRLS-GNSRLTINEELDVM----ELLLATSGSKKRSGGKD-DDFVDARELADQLADFNRRAFGA 111
            ||.:| ..:||.:|.:...|    .:.:||......:|||| :.||....|..  .|.|      
  Fly   460 SFVISIEKNRLILNIDQRPMTTTKSMQVATGAQYYIAGGKDKNGFVGCMRLIS--VDGN------ 516

  Fly   112 NGLSAMLRVQQNRTRGSM------ALLRRFQTRLRALENRVDRMKTDLEANSCASGPCENGGTCY 170
                  .::.|:..:|..      .::...|        .:||         |...||::.|.|:
  Fly   517 ------YKLPQDWVKGEEVCCGDDVVVDACQ--------MIDR---------CNPNPCQHKGLCH 558

  Fly   171 NTYTGFRCQC-RSAFEGTKC------------------------EMDVNECALYEGTDLGCQ--- 207
            .....|.|.| .:.:.|..|                        .:||:.....|...:.|:   
  Fly   559 QNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYS 623

  Fly   208 NG------GQCQNHFGTYSCLCQPG------------------WHGMH-CTQRKADCSQSS---- 243
            :|      ...|.|..|.....:||                  .:..| |.||.:...:||    
  Fly   624 DGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFN 688

  Fly   244 -----------AWELCGH----------------------GSCVPSADDAGYRCICEPG---WKT 272
                       :|.:..|                      |.|    .|....|.|:..   |..
  Fly   689 SPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKC----HDPTKWCNCDSNSLEWME 749

  Fly   273 NG-------------------------------LTPICGEDVDECSDSAAHKPCSTSCINLPGSF 306
            :|                               |.|:..|..|..|:....:....| ||||   
  Fly   750 DGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADAS-INLP--- 810

  Fly   307 TCAPCPAGLTGNGVSCRDLDECQTN-----------------NGGCSLSPKVDC------INTYG 348
                 |..:..:|....:....|.|                 |||..|..:...      :|...
  Fly   811 -----PFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGT 870

  Fly   349 SYHCGECPVGW----TGDGRKCERSPQDIDIPAGQTPRTCPAGNNPCYPTASCFLISGTTSCR-- 407
            |||..:  ..|    ....||..|...|..|.|....   |.|........|..:|..||..|  
  Fly   871 SYHLND--NNWHTVSVERNRKEARLVVDGSIKAEVRE---PPGPVRALHLTSDLVIGATTEYRDG 930

  Fly   408 ---CPMGMVGTG-------------YG-PNGCVNGTTTNCKENPCLNGGICL--FAGPSNYTCLC 453
               |...::..|             || ..|||.    .|:.|||||.|.|:  :.|   |:|.|
  Fly   931 YVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVG----RCESNPCLNNGTCIERYDG---YSCDC 988

  Fly   454 P-IGFRPPICEPQ------PSPCDQHPCKNGGRCRPTTSGDLFV--CQCLPGYRGRLCETRFSSC 509
            . ..|:.|||..:      .|...::..:  |..|.|.:.::.|  ...:|  :|.|.....:..
  Fly   989 RWSAFKGPICADEIGVNLRSSSIIRYEFE--GSFRSTIAENIRVGFTTTIP--KGFLLGFSSNLT 1049

  Fly   510 NGMLSAQ---SGRLR-------------YPPE--GTGYEHNAQCAWVIRTNESLVV-------NV 549
            ...|:.|   ||.||             :|.:  |.|..|:..  ::.:...|.||       .|
  Fly  1050 GEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMH--FMRKNGGSTVVLKVDNYEPV 1112

  Fly   550 TFNSFDVEDSTECRFD---WLQINDGRSAAAQIIGRYCGNHLPHGG--------------NIVSS 597
            .:| ||::.|.:.:|:   ::.|....|.....:|  |.:.:....              |:.|.
  Fly  1113 EYN-FDIKASADAQFNNIQYMYIGKNESMTDGFVG--CVSRVQFDDIYPLKLMFQQNPPKNVKSL 1174

  Fly   598 GNQL 601
            |.||
  Fly  1175 GTQL 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 EGF_CA 156..190 CDD:238011 10/58 (17%)
EGF_CA 192..233 CDD:238011 11/68 (16%)
EGF_CA 282..322 CDD:214542 9/39 (23%)
EGF_3 328..366 CDD:289699 12/64 (19%)
EGF 430..457 CDD:278437 12/29 (41%)
EGF_CA 469..503 CDD:238011 7/35 (20%)
CUB 509..622 CDD:238001 28/135 (21%)
CUB 627..737 CDD:238001
CUB 744..849 CDD:294042
CUB 853..970 CDD:238001
CUB 978..1094 CDD:238001
CUB 1100..1211 CDD:238001
CUB 1216..1330 CDD:238001
CUB 1446..1549 CDD:238001
CUB 1554..1667 CDD:238001
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:294042
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
Nrx-IVNP_524034.2 FA58C 46..185 CDD:214572
FA58C 57..184 CDD:238014
LamG 192..340 CDD:238058
LamG 376..514 CDD:238058 16/55 (29%)
EGF 546..575 CDD:278437 8/28 (29%)
Laminin_G_2 824..943 CDD:280389 25/123 (20%)
EGF_CA 966..998 CDD:238011 14/34 (41%)
Laminin_G_2 1032..1156 CDD:280389 26/130 (20%)
4.1m 1239..1255 CDD:128590
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45444891
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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