DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cubn and Tll2

DIOPT Version :9

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:NP_001178827.1 Gene:Tll2 / 365460 RGDID:1559756 Length:1014 Species:Rattus norvegicus


Alignment Length:1214 Identity:281/1214 - (23%)
Similarity:443/1214 - (36%) Gaps:324/1214 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   541 TNESLVVNVTFNSFDVEDSTECRFDWLQINDGRSAAAQIIGRYCGNHLPHGGNIVSSGNQLYLWF 605
            |.:...|.:.:.:.:.|:.|| :...||.:|...||.            ..|:|....:.|.| |
  Rat    25 TGDHSDVALDYGALEGEEGTE-QEQQLQYHDPCKAAV------------FWGDIALDEDDLKL-F 75

  Fly   606 RSDNSTAKEGFDLTWNSMEPQCGGRLNFETHGTLASPGSPGNYPKNRDCRWQLVAPTTKRIKLTF 670
            ..|.:.     |.|..|||     |:..:|.|.           :....||.             
  Rat    76 HIDKAE-----DWTKPSME-----RMGHDTGGL-----------EETSARWP------------- 106

  Fly   671 FSLQLEQHANCNFDYVLIKDSISGRELAKYCTTGAPAPLLLPTHLAEIHFHSDAEGSDTGFQLHY 735
                              .|:.|...:......|..:..|||.                      
  Rat   107 ------------------NDTASNSSIQALRKDGKDSTTLLPG---------------------- 131

  Fly   736 SVEERVPGCGGVYTAK--EGTISESSTANTE---PGGVSCEYEIHLAVG------EQVVIQFARL 789
                  ||.... |||  ...:..::|:.||   ||||     |...:|      ::.:.:.|..
  Rat   132 ------PGTSNT-TAKTFSARVRRATTSRTERIWPGGV-----IPYVIGGNFTGTQRAIFKQAMR 184

  Fly   790 ELDPLDCLEVLDITDEGGSIL-QEKICGSDASRLNPPTFTSEFNRLKIKFYARAGSFQ-LNYRMA 852
            ..:...|:..::.|||...|: ..:.||.          .|...|       |.|..| ::....
  Rat   185 HWEKHTCVTFIERTDEESFIVFSYRTCGC----------CSYVGR-------RGGGPQAISIGKN 232

  Fly   853 CDYKLN---NEQGTITSPGYPNLTRSDRICTYTI--------------STATNTVISLKRIDFQL 900
            || |..   :|.|.:....:.: ||.||....||              ......|.||       
  Rat   233 CD-KFGIVAHELGHVVGFWHEH-TRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSL------- 288

  Fly   901 TNGESDDDDNDECLTTNLRINDGLNRKILGPYCGKNQPEENFVSETNYLQLHLSTDVDSMGRGFK 965
              ||:.|.|:......| ..:.|:....:.|     :.::|.|..|...::.||....:..|.. 
  Rat   289 --GETYDFDSIMHYARN-TFSRGVFLDTILP-----RRDDNGVRPTIGQRVRLSQGDIAQARKL- 344

  Fly   966 FEYRALATGNDKCGGVHTRSGDHIRLPVHDDSYAGEATCYWVIMAPANKAIRLHWNSFSLENAVD 1030
              |:..|     ||.....:..:...|...:.|...:.|.|.|.....:.|.|::.|..|..:..
  Rat   345 --YKCPA-----CGETLQDTSGNFSAPGFPNGYPSYSHCVWRISVTPGEKIILNFTSMDLFKSRL 402

  Fly  1031 CIYDYLEIYDSLGAQVNDERSKP-LAKYCGNSVPEDLLSHSRQLVLKFVSDYSESDGGFDLTYTF 1094
            |.|||:||.|...      |..| |.::||:.|||.|:|...:|.::|.|..|....||...|  
  Rat   403 CWYDYVEIRDGYW------RKAPLLGRFCGDKVPEPLVSSDSRLWVEFRSSSSILGKGFFAVY-- 459

  Fly  1095 EDRAKCGGHIHASSGELTSPEYPANYSAGLDCDWHLTGTIDHLLEIQVENFELEQSPNCSADYLE 1159
              .|.|||.|...:|::.||.||.:|....:|.|.:|......:.:..::||:|:..:|:.||||
  Rat   460 --EAMCGGDITKDAGQIQSPNYPDDYRPSKECVWRITVADGFHVGLTFQSFEIERHDSCAYDYLE 522

  Fly  1160 VRNGGGTDSPLIGRFCGRDIPARIPGFSHEMRLILHTDSAINGRGF---------RLRW------ 1209
            :|:|...:|.|||.|||.:.|..:...::.:.:...:|.:||..||         ...|      
  Rat   523 IRDGPTEESALIGHFCGYEKPEAVKSSANRLWVKFVSDGSINKAGFAASFFKEVDECSWPDHGGC 587

  Fly  1210 -------------------------RIFAFGCGGSLRSNMGAISSPRYPNSYPNMAHCEWRISLH 1249
                                     :.....|||.:....|.|:||.:|..||...:|.|::...
  Rat   588 EQRCVNTLGSYTCACDPGYELAANKKTCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAP 652

  Fly  1250 PGSGISLLIEDLELEGLSNCYYDSVKIYTGIKLPNQSPCKVLCKDDDLHN--------PLIQLEN 1306
            ....|||..|..||||...|.||.|::.:|:     ||      |..||.        .:|..::
  Rat   653 MQYRISLQFEAFELEGNDVCKYDFVEVRSGL-----SP------DAKLHGKFCGSETPEVITSQS 706

  Fly  1307 NKGTIVFDSDASNTFRGFR---ISYKANCIRNLTATTGTIESLNYMEPFWETIPINCSWTIRAPK 1368
            |...:.|.||.:.:.||||   .|.|..|.::    .|..:.        |.:....|:..|...
  Rat   707 NNMRVEFKSDNTVSKRGFRAHFFSDKDECAKD----NGGCQQ--------ECVNTFGSYLCRCRN 759

  Fly  1369 GNRVLVEVSHLARHEQHVPTATMPGGLYIVDGRNVQEIVTPQAMNISGEVLTVVHNASNVNFQLD 1433
            |.|:         ||               :|.:.:|.                           
  Rat   760 GYRL---------HE---------------NGHDCKEA--------------------------- 773

  Fly  1434 YRIDGCMEELRGTFGFFQSPNYPKMYPNNLECYWLITVEQDSAIELTINNIDLEDSPNCTKDALT 1498
                ||..::....|...|||:|..||:..||.|.|:......:::|.:..::|....|..|.|.
  Rat   774 ----GCAYKISSAEGTLMSPNWPDKYPSRKECTWNISSTAGHRVKITFSEFEVEQHQECAYDHLE 834

  Fly  1499 V-SNHKNSVEVHERHCGSTTKLVITSSGHRLHVRFISDNSHNGLGFEATYRTVKATCGGKLTARN 1562
            : ....:|..:..|.|||.....:.::|..|.:||.||.|....||:|.:.|   .|||:|.|..
  Rat   835 LYDGTDSSAPILGRFCGSKKPDPVVATGSSLFLRFYSDASVQRKGFQAVHST---ECGGRLKAEV 896

  Fly  1563 GVIESPNYPL----NYPAHSRCEWQVEVSQHHQIVFEMADLNLESGYDCNWDYLEAYDLTEDDTE 1623
            ...|..::..    |||:.:.|:|.:.....:.:........:|...||.:|||||||  ..|:.
  Rat   897 QTKELYSHAQFGDNNYPSQAHCDWVIVAEDGYGVELVFRTFEVEEEADCGYDYLEAYD--GYDSS 959

  Fly  1624 GERLFKVCGDETEDDKLLSSSSNMAVVRFISDDSVSKKGFRLHF 1667
            ..||.:.||....::  :.|:.:..::.|.:||:::||||...:
  Rat   960 APRLGRFCGSGPLEE--IYSAGDSLMIHFHTDDTINKKGFHARY 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_3 328..366 CDD:289699
EGF 430..457 CDD:278437
EGF_CA 469..503 CDD:238011
CUB 509..622 CDD:238001 18/80 (23%)
CUB 627..737 CDD:238001 11/109 (10%)
CUB 744..849 CDD:294042 25/117 (21%)
CUB 853..970 CDD:238001 28/133 (21%)
CUB 978..1094 CDD:238001 35/116 (30%)
CUB 1100..1211 CDD:238001 37/150 (25%)
CUB 1216..1330 CDD:238001 40/124 (32%)
CUB 1446..1549 CDD:238001 31/103 (30%)
CUB 1554..1667 CDD:238001 34/116 (29%)
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:294042
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
Tll2NP_001178827.1 ZnMc_BMP1_TLD 149..348 CDD:239808 50/240 (21%)
Astacin 156..349 CDD:279708 47/234 (20%)
CUB 350..459 CDD:278839 34/114 (30%)
CUB 463..572 CDD:278839 36/108 (33%)
FXa_inhibition 583..615 CDD:291342 0/31 (0%)
CUB 619..728 CDD:278839 39/119 (33%)
FXa_inhibition 735..770 CDD:291342 10/70 (14%)
CUB 775..884 CDD:278839 32/108 (30%)
CUB 888..1001 CDD:278839 34/116 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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