DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cubn and Mfrp

DIOPT Version :9

Sequence 1:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster
Sequence 2:	NP_001101607.1	Gene:	Mfrp / 315597	RGDID:	1307477	Length:	590	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	86/321 - (26%)
Similarity:	122/321 - (38%)	Gaps:	64/321 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1387 PTATMPGGLYIVDGRNVQEIVTPQAMNISGEVLTVVHNASNVNFQLDYRIDGCMEELRGTFGFFQ 1451
            ||..:|.   ...........||.........::..|..:            |...|.|..|||.
  Rat   113 PTGVIPS---TTPNTTTTTTTTPAITGRQEAAMSPTHQTT------------CGGLLPGPSGFFS 162

  Fly  1452 SPNYPKMYPNNLECYWLITVEQDSAIELTINNIDLEDSPNCTKDALTVSNHKNSVEVHERHCGST 1516
            |||||.:||.:..|.|.|.|.....|:|.|..:..|....|..|.|.:|.......:  |.||.|
  Rat   163 SPNYPDLYPPHSHCVWHIQVATGQTIQLKIQVLSTESMLACLFDRLEISPAPTGPLL--RMCGKT 225

  Fly  1517 TKLVITSSGHRLHVRFISDNSHNGLGFEATYRTV------------------------------- 1550
            ....:.::...|.|.|:|||...|.||:|.|:.|
  Rat   226 PPATVNTNTSHLRVSFVSDNDVEGSGFQAWYQAVAPGHWSCTHYEFHCDLLLCLKQDSVCDGIKD 290

  Fly  1551 -------------KATCGGKLTARNGVIESPNYPLNYPAHSRCEWQVEVSQHHQIVFEMADLNLE 1602
                         ...|||.||..:||..:||||.:||....|.|.::|...::|..|..:.:||
  Rat   291 CIDGSDEANCSAKTLGCGGNLTELSGVFSTPNYPQHYPHQQLCTWYIKVPVGYRIRLEFHNFSLE 355

  Fly  1603 SGYDCNWDYLEAYDLTEDDTEGERLFKVCGDETEDDKLLSSSSNMAVVRFISDDSVSKKGF 1663
            ...:|.:||:|.|:.:...|... |.:.||.| ....|:||...:.|: |.:|..:|..||
  Rat   356 EQTECKFDYVEVYEASNSGTFSS-LGRFCGAE-PPSHLVSSQHQLTVI-FKTDLGISSGGF 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	282..322	CDD:214542
		EGF_3	328..366	CDD:289699
		EGF	430..457	CDD:278437
		EGF_CA	469..503	CDD:238011
		CUB	509..622	CDD:238001
		CUB	627..737	CDD:238001
		CUB	744..849	CDD:294042
		CUB	853..970	CDD:238001
		CUB	978..1094	CDD:238001
		CUB	1100..1211	CDD:238001
		CUB	1216..1330	CDD:238001
		CUB	1446..1549	CDD:238001	37/102 (36%)
		CUB	1554..1667	CDD:238001	39/110 (35%)
		CUB	1792..1899	CDD:238001
		CUB	1910..1998	CDD:294042
		CUB	2019..2133	CDD:238001
		CUB	2140..2242	CDD:238001
		CUB	2263..2379	CDD:238001
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:294042
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001
		CUB	3254..3363	CDD:238001
		CUB	3379..3508	CDD:238001
		CUB	3531..3601	CDD:294042
		CUB	3623..3733	CDD:238001
Mfrp	NP_001101607.1	CUB	150..258	CDD:238001	40/109 (37%)
		LDLa	266..300	CDD:238060	0/33 (0%)
		CUB	307..419	CDD:238001	39/110 (35%)
		Fz	477..579	CDD:279700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4292
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810