DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cubn and Cdcp2

DIOPT Version :9

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:XP_038967409.1 Gene:Cdcp2 / 298306 RGDID:1563467 Length:566 Species:Rattus norvegicus


Alignment Length:605 Identity:152/605 - (25%)
Similarity:219/605 - (36%) Gaps:149/605 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1091 TYTFEDRAKCGGHIHASSGELTSPEYPANYSAGLDCDWHLTGTIDHLLEIQVENFELEQSPNCSA 1155
            :::.....||||.:.|.||..:||.:|:.|....:|.|.:.......:.:....|:||....|..
  Rat    47 SFSLASGVKCGGVLSAPSGNFSSPNFPSLYPYNTECSWLIVVAEGSSVLLTFHTFDLEYHDTCGF 111

  Fly  1156 DYLEVRNGGGTD-SPLIGRFCGRDIPARIPGFSHEMRLILHTDSAINGRGFRLRWRIFAFGCGGS 1219
            |:||:.||...| ..|:|||||:..|.......|.|.::.|:|..:..|||...::...  |||.
  Rat   112 DFLEIYNGASRDKGNLLGRFCGQAPPPPFTSSWHVMSVVFHSDKHVASRGFSAGYQKDV--CGGV 174

  Fly  1220 LRSNMGAISSPRYPNSYPNMAHCEWRISLHPGSGISLLIEDLELEGLSNCYYDSVKI-------- 1276
            |....|.:|||.|||:|||...|.|.|.....:.:.|:..|.::||...|.||.|.:        
  Rat   175 LTGLSGILSSPEYPNNYPNNVECHWLIRASGPATVKLVFVDFQVEGSEECMYDHVTVLGAPGPAH 239

  Fly  1277 ---YTGIKLPNQSPCKVLCKDDDLHNPLIQLENNKGTIVFDSDASNTFRGFRISY-KANCIRNLT 1337
               |.|...|                |.:....::..:||.||.:...|||:..| ...|....|
  Rat   240 GHHYCGSTRP----------------PTLVSLGHELQVVFKSDFNIGGRGFKAHYFSGECQEVFT 288

  Fly  1338 ATTGTIESLNYMEPFWETIPINCSWTIRAPKGNRVLVEVSHLARHEQHVPTATMP-GGLYIVDGR 1401
            |..|...|..|...:...  |.|.||||.|.|.||.|.|..|...|.:..|.|.. ..|...||.
  Rat   289 AVRGNFSSPQYPGAYPNN--IRCHWTIRLPPGYRVKVFVLDLGLEEPNSLTRTCDFDHLAAFDGA 351

  Fly  1402 NVQ---------EIVTPQAMNISGEVLTVVHNASNVNFQLDYRIDGCMEELRGTFGFFQSPNYPK 1457
            :.:         ..:.|...:...::|.::|..                  |.|.|...|..|..
  Rat   352 SEEAKLLGKWCGHHLPPPVTSSHNQLLLLLHTD------------------RSTSGRGFSVAYIG 398

  Fly  1458 MYPNNLEC-----YWLITVEQDSAIELTINNIDLEDSPNCTKDALTVSNHKNSVEVHERHCGSTT 1517
            :.|.|:.|     ..||:.:..:.:|.|                        .|.:..|.|.:..
  Rat   399 VVPMNVSCSRTDFQILISAQALAPLERT------------------------KVYLGSRSCAAQE 439

  Fly  1518 KLVITSSGHRLHVRFISDNSHNGLGFEATYRTVKATCGGKLTARN--GVIESPNYPLNYPA--HS 1578
                ..|..|:..||                   .|||.:...||  .||.|..| |::.|  ||
  Rat   440 ----VGSNFRIQARF-------------------DTCGSESQRRNNTSVIVSVLY-LDFSAAGHS 480

  Fly  1579 -------RCE-WQVEVSQHHQIVFEMADLNLESGYDCNWDYLEAYDLTEDDTEGERLFKVCGDET 1635
                   ||| .:.|.|.|           |.||.|....|....:..::...|           
  Rat   481 DIHEYEVRCEPRRKEASVH-----------LLSGSDLLGSYAATAEHLQEAPPG----------- 523

  Fly  1636 EDDKLLSSSSNMAVVRFISD 1655
            |::::|.....| |.:..||
  Rat   524 EEEEILEGPGTM-VTQDTSD 542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_3 328..366 CDD:289699
EGF 430..457 CDD:278437
EGF_CA 469..503 CDD:238011
CUB 509..622 CDD:238001
CUB 627..737 CDD:238001
CUB 744..849 CDD:294042
CUB 853..970 CDD:238001
CUB 978..1094 CDD:238001 0/2 (0%)
CUB 1100..1211 CDD:238001 36/111 (32%)
CUB 1216..1330 CDD:238001 37/125 (30%)
CUB 1446..1549 CDD:238001 18/107 (17%)
CUB 1554..1667 CDD:238001 30/114 (26%)
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:294042
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
Cdcp2XP_038967409.1 CUB 56..167 CDD:238001 36/110 (33%)
CUB 171..280 CDD:238001 37/124 (30%)
CUB 283..396 CDD:238001 32/132 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 80 1.000 Domainoid score I8446
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4105at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

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