DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cubn and Mfrp

DIOPT Version :9

Sequence 1:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster
Sequence 2:	NP_667337.1	Gene:	Mfrp / 259172	MGIID:	2385957	Length:	584	Species:	Mus musculus

Alignment Length:	269	Identity:	80/269 - (29%)
Similarity:	113/269 - (42%)	Gaps:	49/269 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1439 CMEELRGTFGFFQSPNYPKMYPNNLECYWLITVEQDSAIELTINNIDLEDSPNCTKDALTVSNHK 1503
            |...|.|..|||.|||||.:||....|.|.|.|.....|:|.|..:.:|....|..|.|.:.:..
Mouse   150 CGGLLPGPSGFFSSPNYPDLYPPLSHCVWHIQVAAGQTIQLKIQALSIESMLTCLFDRLEIISEP 214

  Fly  1504 NSVEVHERHCGSTTKLVITSSGHRLHVRFISDNSHNGLGFEATYRTV------------------ 1550
            ....:  |.||.|....:.::...|.|.|:|||...|.||:|.|:.|
Mouse   215 TGPLL--RVCGKTPPATLNTNTSHLRVSFVSDNDVEGSGFQAWYQAVAPGHWSCAHNEFHCDLLL 277

  Fly  1551 --------------------------KATCGGKLTARNGVIESPNYPLNYPAHSRCEWQVEVSQH 1589
                                      ...|||.||...||..:||||.:||....|.|.:||...
Mouse   278 CLKRDSVCDGITECADGSDEANCSAKTLGCGGNLTGLYGVFSTPNYPQHYPHQQLCTWYIEVPVG 342

  Fly  1590 HQIVFEMADLNLESGYDCNWDYLEAYDLTEDDTEGERLFKVCGDETEDDKLLSSSSNMAVVRFIS 1654
            :.|..|..:.:||:..:|.:||:|.|:.:...| ...|.:.||.|...: ::||...:||: |.:
Mouse   343 YGIRLEFHNFSLEAQAECKFDYVEVYEASNLGT-FSFLGRFCGAEPPLN-VVSSMHQLAVI-FKT 404

  Fly  1655 DDSVSKKGF 1663
            |..:|..||
Mouse   405 DLGISSGGF 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	282..322	CDD:214542
		EGF_3	328..366	CDD:289699
		EGF	430..457	CDD:278437
		EGF_CA	469..503	CDD:238011
		CUB	509..622	CDD:238001
		CUB	627..737	CDD:238001
		CUB	744..849	CDD:294042
		CUB	853..970	CDD:238001
		CUB	978..1094	CDD:238001
		CUB	1100..1211	CDD:238001
		CUB	1216..1330	CDD:238001
		CUB	1446..1549	CDD:238001	36/102 (35%)
		CUB	1554..1667	CDD:238001	40/110 (36%)
		CUB	1792..1899	CDD:238001
		CUB	1910..1998	CDD:294042
		CUB	2019..2133	CDD:238001
		CUB	2140..2242	CDD:238001
		CUB	2263..2379	CDD:238001
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:294042
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001
		CUB	3254..3363	CDD:238001
		CUB	3379..3508	CDD:238001
		CUB	3531..3601	CDD:294042
		CUB	3623..3733	CDD:238001
Mfrp	NP_667337.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..140
		CUB	150..258	CDD:238001	39/109 (36%)
		LDLa	266..300	CDD:238060	0/33 (0%)
		CUB	307..419	CDD:238001	40/110 (36%)
		Fz	471..573	CDD:279700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4292
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810