DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn and F5

DIOPT Version :10

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:NP_000121.2 Gene:F5 / 2153 HGNCID:3542 Length:2224 Species:Homo sapiens


Alignment Length:1956 Identity:337/1956 - (17%)
Similarity:577/1956 - (29%) Gaps:747/1956 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  2044 QDLNCFWTLVPSN----------PAMHAVLTLSQID-LEIFSEDCIADY-----------VKIFS 2086
            :|:.|    :|.:          |....:.|....| ||...|:..|||           ::.|.
Human   680 RDVKC----IPDDDEDSYEIFEPPESTVMATRKMHDRLEPEDEESDADYDYQNRLAAALGIRSFR 740

  Fly  2087 GSDLQNWSELRTLCSLPTESSDRVFHGRPYLRVEFVTDPSVNKTGFNGIVRTACGSEITASKGLV 2151
            .|.|....|...|.:|..|:.           .|||:      :..:.||.:...|....||..|
Human   741 NSSLNQEEEEFNLTALALENG-----------TEFVS------SNTDIIVGSNYSSPSNISKFTV 788

  Fly  2152 -NITEILKVLPRPNHDCVWTIKVRQGRRIKIDFPDFQLQNNMASGSS----DCRNYLLLRNGNDE 2211
             |:.|..|.   |:|                       |....:||.    ..:|.:|..:..:.
Human   789 NNLAEPQKA---PSH-----------------------QQATTAGSPLRHLIGKNSVLNSSTAEH 827

  Fly  2212 DSPFLGRGKYCEDVVHEVLNTSSNKAYIKFHFASPPRFLVSFRFEELRYTDSGRIRLSASGDEQF 2276
            .||      |.||.:.:.|.                             .|...|||.:.|..:|
Human   828 SSP------YSEDPIEDPLQ-----------------------------PDVTGIRLLSLGAGEF 857

  Fly  2277 ISSPYYPH----------LPHPHSECIWIVEAPPEHRIMLHFQGAFDMLDATGEPEECQREFVLI 2331
            .|..:..|          ..|..|   |:       :::.|..|.....| ||.|.         
Human   858 KSQEHAKHKGPKVERDQAAKHRFS---WM-------KLLAHKVGRHLSQD-TGSPS--------- 902

  Fly  2332 NDGSTELRPEIGRYCGNRKPDTIYS--TGNQMRIRYFTDVSEPHMGFNASLSVARCGGSFH---- 2390
                           |.|..:.:.|  ||:..|:|.:.|.....:....|.|.....|.:|    
Human   903 ---------------GMRPWEDLPSQDTGSPSRMRPWKDPPSDLLLLKQSNSSKILVGRWHLASE 952

  Fly  2391 ---------------------SPEGVIASPSRDLLLIHEEGKQ--------LQECVYTIELEKGS 2426
                                 ||:....:......|.::.|||        ::.....:..:.|.
Human   953 KGSYEIIQDTDEDTAVNNWLISPQNASRAWGESTPLANKPGKQSGHPKFPRVRHKSLQVRQDGGK 1017

  Fly  2427 TIDLTSEYLQIPTLRNGSCSQRNHLMLE-------EMDAFGLDGEEKIVDTLMLCGMEAKHLISE 2484
            :....|::| |.|.:.......:|..|.       ..:|:....|.::..:|:|.......|.::
Human  1018 SRLKKSQFL-IKTRKKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPTD 1081

  Fly  2485 TNKIV--FRYRFLDGIPAENQGFRLKYTSLGSRCGETIYASV--GVLQT-------PGYPLGVPH 2538
            .|:.:  ..:.::..:|..||          :...:|..||.  |:.||       ..:|:..|.
Human  1082 LNQTLPSMDFGWIASLPDHNQ----------NSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPD 1136

  Fly  2539 PMHCK----------------------------------------WQVQV-PKGRRVRLEILDFN 2562
            .||..                                        ||..: |...:|.|......
Human  1137 QMHSTSDPSHRSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELSQ 1201

  Fly  2563 TGTNMDLRGRLGFRGRLTVANDFKMQSI---LGRYNVDPPAE--VLSSD---NTMGIDAFLLPIV 2619
            |..:.||       ...|::.:...:::   ||:..:.|...  .||.|   .|:.:|      :
Human  1202 TNLSPDL-------SHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLD------L 1253

  Fly  2620 QNHGIKLRFSAYGSSSCPGFTVMMNEVA----DIQFQRFNISRPLHCSYKVVPPSNSTLLIRVKE 2680
            ....:....|....|...|...:..:::    .:.|.:.|:|..|         |:.||...:.:
Human  1254 SQTNLSPELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPEL---------SHMTLSPELSQ 1309

  Fly  2681 YNTTSV---MMWNTHMCALLSPLKFNRLEQEEELMERILCDYQSPAPGK-PLPSIRLPFPIQLVV 2741
            .|.:..   |..:..:......|.|::.....||.:..|    |||.|: ||.    |.|....:
Human  1310 TNLSPALGQMPISPDLSHTTLSLDFSQTNLSPELSQTNL----SPALGQMPLS----PDPSHTTL 1366

  Fly  2742 SASARNAMTNLVLSYSTQSCG------------GVIILEPG-DNMTVHQPSGMVSAAGAIDCAWA 2793
            |...  :.|||....|..:..            ..|.|.|. |.||: .|.     .|..|.:..
Human  1367 SLDL--SQTNLSPELSQTNLSPDLSEMPLFADLSQIPLTPDLDQMTL-SPD-----LGETDLSPN 1423

  Fly  2794 IGPYTDASGEDEVLVPQDIQLEVSVYNVNLPAPSPS-------AQSPEAPCLHHYLKVYNGPD-- 2849
            .|..:.:....:|.:..||.....:.:::..:|.|.       ::|.::..|..:.:.:..||  
Human  1424 FGQMSLSPDLSQVTLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLG 1488

  Fly  2850 ----QNSPSLGLFCNQATAVNMVVERGLFLEYHSDSFSANATFNVSIKYGSGCGGK---LVYP-- 2905
                .:||:|                       :|:| .:..||..:..|....|.   .:.|  
Human  1489 QMPSPSSPTL-----------------------NDTF-LSKEFNPLVIVGLSKDGTDYIEIIPKE 1529

  Fly  2906 --------YRAIDFA---EQYKNNVE------------CIWEVEATMGYHIGLTFQGRFYIEDSP 2947
                    |..||:.   :.||.:|.            ..|.:.:..|       ..|.|...:.
Human  1530 EVQSSEDDYAEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNG-------NRRNYYIAAE 1587

  Fly  2948 GCTKDYLLVQQRNETTGNWTDLQRICGRVAPEMINTTSPYLRLIFRSDGDVVADGFLAKFERNCG 3012
            ..:.||....||.....:..|:        ||  :||  |.:::||.                  
Human  1588 EISWDYSEFVQRETDIEDSDDI--------PE--DTT--YKKVVFRK------------------ 1622

  Fly  3013 GLLYADSTEQELASPGFPNG-YEKYLQCNWTIVPRSPSMGGVLVSFVNFDLEQGPISVCLYDNLT 3076
               |.|||    .:...|.| ||::|              |:|...:..:::         |.:.
Human  1623 ---YLDST----FTKRDPRGEYEEHL--------------GILGPIIRAEVD---------DVIQ 1657

  Fly  3077 VTTKDKGKDPQQTTLCGVKHNHEYRGKEYVNLLLRTDGSYSGRGFTLLYTSRLCGGIISRTSMVE 3141
            |..|:....|......|:.:.....||.|.:                                 :
Human  1658 VRFKNLASRPYSLHAHGLSYEKSSEGKTYED---------------------------------D 1689

  Fly  3142 SPVQ-HTDNTLPPGSD--CYWNLTAPAGYKFNIKFLFIDFEANSNC---AYDGVEVFSGPIPDER 3200
            ||.. ..||.:.|.|.  ..|:.|..:|.:          ...|.|   ||     :|...|::.
Human  1690 SPEWFKEDNAVQPNSSYTYVWHATERSGPE----------SPGSACRAWAY-----YSAVNPEKD 1739

  Fly  3201 YRWGRFCGRINEDLPLISIPQERGIIHSFSDDRDPSRGFRALVRVMPNCDEKIS----------- 3254
            ...| ..|      ||:..  ::||:|.   |.:.....|..|.:....|||.|           
Human  1740 IHSG-LIG------PLLIC--QKGILHK---DSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSSW 1792

  Fly  3255 -LNGSSRYVYSKFNNAGGYQNDLDCQIVFRVNPDQQISVEFSNFHVQDTDGCRSDYVE------- 3311
             |..|......:|:...|        :::.:...:....|:...|:.:..|.:..:|.       
Human  1793 RLTSSEMKKSHEFHAING--------MIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTL 1849

  Fly  3312 LRDGG-----GTFADIIGRF------------------CGQN-----QPPTLRTTRHT-----LY 3343
            |.:|.     |.:..:.|.|                  .|:|     |.|.|...|..     |.
Human  1850 LENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLS 1914

  Fly  3344 MRFVTDNKVTDTGF-------QVTIN--------AIPRLCG--SSEITLSADGTKEVTINSPART 3391
            ...::|:::..:.|       ...:|        ::.:|..  :|:..:..|..|||.|......
Human  1915 TGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQ 1979

  Fly  3392 PGGNYPNGVSCF--------------WKI-KGDSLLRVQFVNFDLHGPNQNGSCVDDYLKIYNSE 3441
            ...:|..  ||:              |:| ||:|...|.:.|     .|.:.|.:.:     |..
Human  1980 GAKHYLK--SCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFN-----GNSDASTIKE-----NQF 2032

  Fly  3442 DAPLLEQGLGTDLVFNGQTSSKNGFGFATEHVYCGNVKPDIYYGRSSEVYLKFRSKGLEQHG--- 3503
            |.|::.:.:                          .:.|...|.|.:   |:...:|.|.:|   
Human  2033 DPPIVARYI--------------------------RISPTRAYNRPT---LRLELQGCEVNGCST 2068

  Fly  3504 --GFQ------LQVALNSNRERHYD----------GLQGRVHLSQSADCNIIIRAPPNYTLSLYY 3550
              |.:      .|:..:|.::..:.          ..||||:..|:...|               
Human  2069 PLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANN--------------- 2118

  Fly  3551 TELIFGTYDCEMENLEVFDRTNRSLQRVCSFVDMG-KSLFSNANELRLQMKTGSYLTSLDLTYLA 3614
                         |.:..:.....::::.:.:..| |||.|.           .|:.|..:.|..
Human  2119 -------------NKQWLEIDLLKIKKITAIITQGCKSLSSE-----------MYVKSYTIHYSE 2159

  Fly  3615 SPVEKGPGCGGQFY---------------NTEGIFSNPFYPNNVRNNSECQWIVRVPS--NNVVF 3662
            ..||..|      |               ||:|...|.|.|..:     .::|..:|.  |..:.
Human  2160 QGVEWKP------YRLKSSMVDKIFEGNTNTKGHVKNFFNPPII-----SRFIRVIPKTWNQSIA 2213

  Fly  3663 LTFEVF 3668
            |..|:|
Human  2214 LRLELF 2219

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 cubilin_NTD 21..149 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_CA 324..367 CDD:214542
EGF 430..457 CDD:394967
EGF_CA 469..503 CDD:238011
CUB 509..622 CDD:238001
CUB 627..737 CDD:238001
CUB 744..849 CDD:412131
CUB 853..970 CDD:238001
CUB 978..1094 CDD:238001
CUB 1100..1211 CDD:238001
CUB 1216..1330 CDD:238001
CUB 1446..1549 CDD:238001
CUB 1554..1667 CDD:238001
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:412131
CUB 2019..2133 CDD:238001 22/110 (20%)
CUB 2140..2242 CDD:238001 20/106 (19%)
CUB 2263..2379 CDD:238001 24/127 (19%)
CUB 2385..2511 CDD:238001 24/167 (14%)
CUB 2516..2630 CDD:238001 27/171 (16%)
CUB <2833..2892 CDD:412131 10/64 (16%)
CUB 2898..3008 CDD:238001 24/137 (18%)
CUB 3011..3127 CDD:238001 19/116 (16%)
CUB 3130..3241 CDD:238001 23/116 (20%)
CUB 3254..3363 CDD:238001 24/175 (14%)
CUB 3379..3508 CDD:238001 27/154 (18%)
CUB 3531..3601 CDD:412131 7/70 (10%)
CUB 3623..3733 CDD:238001 13/63 (21%)
F5NP_000121.2 Cupredoxin 32..196 CDD:473140
Cupredoxin 208..326 CDD:473140
CuRO_3_FV_like 348..528 CDD:259992
CuRO_4_FV_like 541..684 CDD:259996 1/3 (33%)
B 692..1573 185/1066 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..842 6/54 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 894..927 11/57 (19%)
2 X 17 AA tandem repeats 895..928 12/57 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 982..1001 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1029..1048 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1157 13/69 (19%)
35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T 1185..1501 67/376 (18%)
YjbI 1234..1421 CDD:440968 44/217 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1341..1367 11/33 (33%)
CuRO_5_FV_like 1579..1754 CDD:259993 52/291 (18%)
Cupredoxin 1766..1902 CDD:473140 23/143 (16%)
FA58C 1909..2060 CDD:238014 30/191 (16%)
FA58C 2068..2220 CDD:238014 34/202 (17%)
Blue background indicates that the domain is not in the aligned region.

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