DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cubn and mfrp

DIOPT Version :9

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:XP_009289590.1 Gene:mfrp / 101885305 ZFINID:ZDB-GENE-160728-150 Length:572 Species:Danio rerio


Alignment Length:386 Identity:98/386 - (25%)
Similarity:146/386 - (37%) Gaps:69/386 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly  1348 YMEPFWETIPINCSWTIRAPKGNRVLVEVSHLARHEQHVPTATMPGGLYIVDGRNVQEIVTPQAM 1412
            |.||..|...:|. .|:||...:...|.||........|...|:...|..|:  ..:|.|:|...
Zfish    40 YFEPAKEPAAVNV-LTVRACLADHRAVLVSAAVLFVSTVLCITLIFLLKQVE--TTKEEVSPSDT 101

  Fly  1413 ---NISGEVLTVVHNASNVNFQLDYRIDG-------CMEELRGTFGFFQSPNYPKMYPNNLECYW 1467
               |...|.|::...|....:.....:.|       |...|.|..|...|||:|.:||.:..|.|
Zfish   102 WFGNRVSENLSLSPTALQPTYSPTVSVSGTEPTFTKCGGMLSGAGGTLSSPNHPGVYPPDSHCVW 166

  Fly  1468 LITVEQDSAIELTINNIDLEDSPNCTKDALTVSNHKNSVEVHERHCGSTTKLVITSSGHRLHVRF 1532
            :|.|...|.:::.::::.:|....|..|.|.|...........|.||:.....:.::...:.|.|
Zfish   167 VIRVSPPSLVQIQVSSLAIEGPSPCLFDWLEVREETEKTSAATRFCGNVAPPTLNTNSSTVLVSF 231

  Fly  1533 ISDNSHNGLGFEATYRTV--------------------------------------------KAT 1553
            .||.|..|.||.|.|.::                                            ...
Zfish   232 HSDGSIGGTGFIAQYHSILPGQRSCSREEFMCDSGHCLLPVFICDGQPNCQDHSDELNCSHKHRV 296

  Fly  1554 CGGKLTARNGVIESPNYPLNYPAHSRCEWQVEVSQHHQIVFEMADLNLESGYDCNWDYLEAYDLT 1618
            |||::|...|.:.|||:|..||....|.||:.|.....|.....:.:||:...|.:||:|.||..
Zfish   297 CGGQITGEYGSLSSPNHPKPYPHQQMCTWQISVEDGQVIRLSFQNFSLEAQDVCKFDYVEVYDGA 361

  Fly  1619 EDDTEGERLFKVCGDETEDDKLLSSSSNMAVVRFISDDSVSKKGFRLHFHESCGQTIIVDE 1679
            |     ..|.:.||.....|  |:||..:..|.|::|:.|:..||...|     |.|.:.|
Zfish   362 E-----TALGRYCGSALPPD--LTSSGPVLTVVFVADEGVADSGFYASF-----QAISLSE 410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_3 328..366 CDD:289699
EGF 430..457 CDD:278437
EGF_CA 469..503 CDD:238011
CUB 509..622 CDD:238001
CUB 627..737 CDD:238001
CUB 744..849 CDD:294042
CUB 853..970 CDD:238001
CUB 978..1094 CDD:238001
CUB 1100..1211 CDD:238001
CUB 1216..1330 CDD:238001
CUB 1446..1549 CDD:238001 30/102 (29%)
CUB 1554..1667 CDD:238001 38/112 (34%)
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:294042
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
mfrpXP_009289590.1 CUB 138..248 CDD:238001 33/109 (30%)
LDLa 256..290 CDD:238060 0/33 (0%)
CUB 297..405 CDD:238001 39/119 (33%)
LDLa 413..447 CDD:238060
Fz 459..563 CDD:279700
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4292
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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