DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn and svep1

DIOPT Version :9

Sequence 1:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster
Sequence 2:XP_012808841.2 Gene:svep1 / 100493788 XenbaseID:XB-GENE-5996067 Length:3695 Species:Xenopus tropicalis


Alignment Length:2823 Identity:537/2823 - (19%)
Similarity:827/2823 - (29%) Gaps:1102/2823 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 ARELADQLADFNRRAFGANGLSAMLRVQQNRTRGSMALLRRFQTRLRALENRVDRMKTDLEA-NS 157
            ||.:|| .:.|. .:|.|...|.|:.:..                    ||...:.|...:. |.
 Frog  1157 ARSIAD-CSSFG-SSFSAAEESVMIPISP--------------------ENVNSKYKVSSQVFNE 1199

  Fly   158 CASGPCENGGTCYNTYTGFRCQCRSAFEGTKCEMDVNECALYEGTDLGCQNGGQCQNHFGTYSCL 222
            |...||:|.|||....:|:.|.|...:.|.|||.::|||     :.:.|:|.|.|.:..|.:.|.
 Frog  1200 CLLNPCQNSGTCTQIGSGYICSCIKGYTGAKCENEINEC-----SSIPCRNNGICIDRVGEFDCQ 1259

  Fly   223 CQPGWHGMHCTQRKADCSQSSAWELCGHGSCVPSADDAGYRCICEPGWKTNGLTPICGEDVDECS 287
            |..|:.|..|.:...:||.:..   .....|:...:  .:.|.|..|:    |.|.|..::||| 
 Frog  1260 CLSGFSGTLCEENINECSSNPC---LNEAICIDGIN--AFYCRCANGF----LGPRCEIEIDEC- 1314

  Fly   288 DSAAHKPCSTSCINLPGSFTCAPCPAGLTGNGVSCRDLDECQTNNGGCSLSPKVDCINTYGSYHC 352
                   .|..|:|                ||| |.||.                     ..:.|
 Frog  1315 -------LSRPCLN----------------NGV-CDDLK---------------------AGFQC 1334

  Fly   353 GECPVGWTGDGRKCERSPQDIDIPAGQTPRTCPAGNNPCYPTASCFLISGTTSCRCPMGMVGTGY 417
             .||.|:|  |:.||:   |||                                           
 Frog  1335 -LCPAGYT--GKVCEK---DID------------------------------------------- 1350

  Fly   418 GPNGCVNGTTTNCKENPCLNGGICLFAGPSNYTCLCPIGFRPPICEPQPSPCDQHPCKNGGRCRP 482
                       .|...||.||..|. .|.:::.|.||.||...:||.....|..:||.|...|  
 Frog  1351 -----------ECLSGPCKNGASCT-DGINSFRCQCPEGFTGQVCEINVDDCVSNPCLNNATC-- 1401

  Fly   483 TTSG-DLFVCQCLPGYRGRLCET----------RFSSCNG---------MLSA--------QSGR 519
             ..| :.::|:|.|||.|..|||          ..|...|         .|||        .|..
 Frog  1402 -VDGLNSYICKCQPGYSGIRCETEQPFGFNLDFEVSGIYGYVLLDNVMPTLSAITCAFWMRSSDT 1465

  Fly   520 LRY-PPEGTGYEHNAQCA--------WVIRTN--ESLV------------VNVTFNSFDVEDSTE 561
            ..| .|.....::.:..|        ||:..|  |.:.            :.||:.:.|  .|.:
 Frog  1466 TNYGTPISYALDNGSDNAFLLTDYNGWVLYINGKEKITDCPSVNDAKWHHIAVTWTNTD--GSWK 1528

  Fly   562 CRFDWLQINDGRSAAAQIIGRYCGNHLPHGG-------------------NIVSSGNQLYLWFRS 607
            ...|..|.:.|:       |...|..:|.||                   :.|.|.:||.:|   
 Frog  1529 VYIDGKQSDGGK-------GLSVGESIPGGGALVLAQEQDQRGEGFNPAESFVGSLSQLNIW--- 1583

  Fly   608 DNSTA---------------KEGFDLTWNSMEPQCGGRLNFE------------------THGTL 639
            |:...               ::|..|.|....|...||:..:                  .|.|.
 Frog  1584 DHPLTPAQIKSLAISCPVELQKGNVLAWADFLPGVVGRVKVDHKSKFCADCPALEGTSPHLHATK 1648

  Fly   640 A--SPGS-------PG----NYPKNRDC----RWQLVAPTTKRIKL--------TFFSLQLEQHA 679
            :  .|||       ||    ..|: |.|    .|....|..:||..        .|::.: :..|
 Frog  1649 SDHKPGSKISLFCNPGFQIVGKPE-RQCLNLGEWDQPLPHCERISCGKPPRLENGFYNAE-DLFA 1711

  Fly   680 ------NCNFDYVLIKDSISGRELAKYCTTGAP----APLLLPTHLAEIHFHSDAEGSDTGFQLH 734
                  .||..|.|:.||      ..:||....    :|..|.....||....|...|.......
 Frog  1712 GSTVTYQCNIGYYLLGDS------RMFCTDNGSWNGISPSCLDVDECEIGSDCDEHASCMNTNGS 1770

  Fly   735 YSVEERVPGCGGVYTAKEGTISESSTANTEPGGV-SCEYE-IHLAVGEQVVIQ----FARLELDP 793
            | :...:|...|     :|..........:||.: :..|. .|..||.|::..    :..:.|..
 Frog  1771 Y-ICTCIPPYHG-----DGKKCLEPVKCKDPGEIENGNYSGNHFGVGSQLMFSCHEGYDLIGLVK 1829

  Fly   794 LDCLEVLDITDEGGSILQEKICGSDASRLNPPTFTSEFNRLKIKFYARAGSFQLNYRMACDYKLN 858
            :.|||..: .|:.....|...||...:..|.....|.|.      :....:|:.|          
 Frog  1830 VTCLESGE-WDDALPYCQAVSCGKVPAPNNGEILGSNFT------FGEIVTFRCN---------- 1877

  Fly   859 NEQGTITSPGYPNLTRSDRIC------TYTISTA-----------TNTVISLKRIDFQLTNGESD 906
                    .||..:...:.:|      ::.:.|.           .|.:.||..:.|..|...: 
 Frog  1878 --------EGYTLIGNEETVCLANRSWSHALPTCESVTCSKPKEIENGIFSLSGLTFNSTASYA- 1933

  Fly   907 DDDNDECLTTNLRINDGLNRKILGPYCGKNQPEENFVSETNYLQL------HLSTDVDSMGRGFK 965
                  |.|         ...:.||.....:...|:.||.....|      .|..|.|:.|.  .
 Frog  1934 ------CKT---------GYSLQGPATLICEASGNWSSEVPSCDLVSCGPPPLVRDADATGD--N 1981

  Fly   966 FEYRALATGNDKCGGVHTRSGDHIRLPVHDDSYAGEATCYWVIMAPANKAIRLHWNSFSLENAVD 1030
            :.|..:.|  .||...:|..|        .|:....::..|....|...|:       |.:...:
 Frog  1982 YTYSNIIT--YKCKEGYTLVG--------PDTINCSSSGKWSEHIPQCMAV-------SCDEPPN 2029

  Fly  1031 CIY-----------DYLEIYDSLGAQVNDERSKPLAKYCGNSVPED----------------LLS 1068
            ..|           |....|.|.|..:.| .::.|....||.||.|                .::
 Frog  2030 VDYASSHSSHRLFGDTAYYYCSDGYSMVD-NAQMLCNTEGNWVPPDGKEIPNCIADFCERPSSVA 2093

  Fly  1069 HSRQLVL------KFVSDYSES---DGGFDLTYTFEDRAKC--GGHIHASSGELTSPEYP----- 1117
            ||   :|      ||||..:.|   ..||.|..|  .|.:|  ||....||  ||....|     
 Frog  2094 HS---ILESVNKAKFVSGSTVSFKCMEGFVLNTT--ARIECVRGGQWIPSS--LTIQCIPVRCGE 2151

  Fly  1118 -----------ANYSAG----LDCD--WHLTGTIDHLLEIQVENFELEQSPNCSADYLEVRNGGG 1165
                       .|||.|    ..||  :::.|               |:...|.|.         
 Frog  2152 PPSIKNGYVSGTNYSFGSVVAYSCDKGYYIKG---------------EKKRTCLAS--------- 2192

  Fly  1166 TDSPLIGRFCGRDIPARIP-----------GFSHEMRLILHTDSAIN--GRGFRLRWRIFAFGCG 1217
                  |.:.|| :||..|           ||......:|:....|.  ..|::|          
 Frog  2193 ------GEWSGR-LPACHPGSCDDPPKLENGFVKSKTGLLYESKVIYACNPGYKL---------- 2240

  Fly  1218 GSLRSNMGAISSPRY------------------PNSYPNMAHCEWRISLHPGSGISLLIED-LEL 1263
              :.||:......|:                  |..|.:|....:.:    ||.:....|| .||
 Frog  2241 --VGSNVRVCQLNRHWYSESPPTCVLLTCEKPPPVKYGSMKGENFEV----GSKVEFFCEDGYEL 2299

  Fly  1264 EG-LS-----NCYYDSVKIYTGIKLPNQSPCKVLCKDDDL---HNPLIQLENNKGTIVFDSDASN 1319
            .| ||     |..:|..      :.|...|.|  |:|..|   |..|.::.|..|.:.|.....:
 Frog  2300 SGDLSWTCQKNGEWDKK------QTPTCMPSK--CQDPPLYENHLVLKEVPNEVGIVRFSCKEGH 2356

  Fly  1320 TFRG------------------------------------------FRISYKANCIRNLTATTGT 1342
            ...|                                          |..:.|..|:........:
 Frog  2357 VLEGSSVLKCLPSQQWNDSFPLCKLVFCSSPPELAYGEPISVPSLYFGSTVKYTCVDGFLLKGES 2421

  Fly  1343 IESLNYMEPFWETIPINCSWTIRAPKGNRVL---VEVSHLARHEQHVPTATMPGGLYI------- 1397
            :.:.| ....|.....||| .|..|:...:|   |:|..|......:.|. .||...|       
 Frog  2422 VITCN-ASGMWSPDFPNCS-PIECPQPEEILNGIVDVQGLTFLSAALYTC-KPGYELIGNSTLIC 2483

  Fly  1398 -VDG--RNVQEIVTPQAMNISGEVLTVVHNASNVNF--------QLDYRIDG-----CMEELRGT 1446
             .||  :..:.|..|...:.:.|:|....:..::|:        ...:|::|     |:|  .|.
 Frog  2484 GADGYWQGGKPICKPIKCSKAKEILNGKFSFQSLNYGQTITYTCNRGFRLEGQNVLTCLE--TGE 2546

  Fly  1447 F--------------------GFFQSPNYP-------KMYPN----------------------- 1461
            :                    ||.:..:|.       ...|.                       
 Frog  2547 WNSNPPICKEITCDPPQGIDNGFVEGADYSYGAMIIFSCMPGFQLVGLAMQTCEESGWSSSTPVC 2611

  Fly  1462 -NLEC----------YWLITVEQ----DSAIELTI---NNIDLEDSPNCTKDALTVSNHKNSVEV 1508
             :.:|          |.::|.|:    |..::.:|   :||.|  ||..|.:.|...||..:.::
 Frog  2612 LHTDCGLPPHIDFGQYTIVTFEEKILTDDELKHSIFGVSNIIL--SPTTTSNTLKTENHSENSQL 2674

  Fly  1509 HERHCGSTTKLVITSSGHRLHVRFISDNSHNGLGFEATYRTVKATCGGKLTA------------R 1561
            .|...|:             :|.:..:|.:..||..........|..|...|            .
 Frog  2675 SEYLYGT-------------NVIYSCNNGYEILGMSVLTCKEDGTWNGSAPACAPIECSIPTDPE 2726

  Fly  1562 NGVIE--------------SPNYPLNYPAHSRC----EWQVEVSQ--------HHQIVF---EMA 1597
            |||:.              .|.|.||....|.|    :|..|:.:        .::|:.   |::
 Frog  2727 NGVMHYTDNTIGSSVHFECKPGYELNGSDKSICLANKQWNNEIPKCVIISCKTPNKILHGYTEVS 2791

  Fly  1598 DLNLES--GYDCNWDYLEAYDLTE------DDTEGERLF---------------KVCGDETEDDK 1639
            :....|  .|.|:..| :.|.|::      ...:||...               ||.|:|....|
 Frog  2792 NYTYMSVIHYKCDKGY-QIYGLSQRTCQISKQWDGEEPICVPVSCGQPPMVINGKVIGNEYTFSK 2855

  Fly  1640 LLSSSSNMAVVRFISDDSVSKKGFRLHFHE--SCGQTIIVDETMFDYIQMSRQAARNESCLWVFQ 1702
            .:              :.|..:|:||:..|  :|             ::....:....|||.:  
 Frog  2856 TI--------------EYVCNEGYRLYGEEIRTC-------------LENGNWSGTTPSCLAI-- 2891

  Fly  1703 AVEPNKRIIFTPTHVKLREDANQQYPTEGDCLNVGVKIY----EGTEPQGTPRL----------- 1752
                         ..|:....|....|..:| .||.:|.    .|.:.||||:|           
 Frog  2892 -------------TCKISTTVNNGEVTGTEC-GVGKEILYRCNHGYKMQGTPKLTCLNDGTWNSN 2942

  Fly  1753 -KFC---RSHPPALISNGQALTVSVPLQLVEE---FQGHYMTMDTSCGSIYN-ALSGKFTSPYYP 1809
             ..|   ...||..||||...:.:........   |.|:.|...::...:.| |.||   ||  |
 Frog  2943 APLCEPIHCEPPEDISNGYLNSSNFKYNEYIHYVCFPGYEMHGSSTRQCLANGAWSG---SP--P 3002

  Fly  1810 ASYPPNIECLWLL---------EASMGNSLSLTLESMDLEKSESCNRDYLEVREESESGQLIG-- 1863
            ...|  .||...:         :.:.|:|:|:           .|...:..:.....:.|..|  
 Frog  3003 TCLP--CECPTPVVQNGIMSGDDFTCGHSVSI-----------KCREGFKLLGSSELTCQSAGKW 3054

  Fly  1864 ----VYCGN-------EVPGVIHSRGAIWMKFKSDDDNVGEGFMASYNYEHHNELNGTEGTIESP 1917
                .:||.       .:|....:..:     .:|:|.:....:|.|..:..:||..|:..:.|.
 Frog  3055 SSGFPHCGKVPCGPPPSIPNAFINGSS-----STDEDAIRYNCVAGYIMQGKSELLCTKEGVWSK 3114

  Fly  1918 HFPS--KFQDPVPYSWRITVDKEYVVAISLLYLRDLDQPHLNFYDGY---SDIGARIEVTD---- 1973
            .:|:  .....:|.|    |....::|.|..|   ....:....|||   .|:.::..:.|    
 Frog  3115 PYPNCQLLSCGLPPS----VLNAVLIADSYTY---GSTANYRCQDGYVMHQDVSSKTCLEDGSWS 3172

  Fly  1974 -------PDETIISSTNVVYFTSNRGPFKLNWNRLSKEALRSNRTAEERTRQCGNQLITIDRSVI 2031
                   |.:.::.||.:                         :...:.|....|:.|||     
 Frog  3173 PGDIVCVPKKCLLQSTLI-------------------------QIKNDETEYDINKTITI----- 3207

  Fly  2032 GFHSPGYPNGYEQDLNCFWTLV-PSNPAMHAVLTLSQIDLEIFSEDCIADYVKIFSGSDLQNWSE 2095
             ....||            ||. ||                  :..|:.|          .||. 
 Frog  3208 -VCKEGY------------TLTGPS------------------TSTCMND----------GNWI- 3230

  Fly  2096 LRTLCSLPTESSDRVFHGRPYLRVEFVTDPSVNKTGFNGIVRTACGSEITASKGLVNITEIL--- 2157
                                         |.||.   |.....:||.......|:|..|..|   
 Frog  3231 -----------------------------PEVNN---NICTPVSCGEPAAPEHGIVLGTRYLFKD 3263

  Fly  2158 KVLPRPN-----HD-----C----VWTIKVRQGRRIKIDFPDFQLQNNMASGSSDCRNYLLLRNG 2208
            .||.:.|     |.     |    :|:....|.::|....|: .|:|.:..|:    .||.    
 Frog  3264 SVLYQCNAGFEIHGPTERVCQINGLWSDVEPQCKKISCHPPE-PLENGVIHGA----GYLF---- 3319

  Fly  2209 NDEDSPFLGRGKYCEDVVH-------EVLNTSSNKAYIKFHFASPPRFLVSFRFEELR------Y 2260
                          ||.:|       |:...|....:|...:..||...||...:.|.      |
 Frog  3320 --------------EDELHYSCNHGFELNGPSRRICHIDKQWIPPPPTCVSVTCDSLPYIENAVY 3370

  Fly  2261 TDSGRIRLSASGDEQFISSPYYPHLPHPHSECI----WIVEAPPEHRIMLHFQGAFDMLDATGEP 2321
            |.:|.   :.:.:..|..:..|..:..||..|:    |....|         |......:...:|
 Frog  3371 TSTGN---TYTHNITFTCNFGYHLVGPPHVRCLVNGTWSKPLP---------QCKETRCEVPQQP 3423

  Fly  2322 EECQREFVLINDGSTELRPEIGRY-CGN 2348
            |....|:..:..|||.      || |.|
 Frog  3424 ENGHAEYENVTVGSTV------RYQCQN 3445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CubnNP_727348.2 EGF_CA 156..190 CDD:238011 13/33 (39%)
EGF_CA 192..233 CDD:238011 12/40 (30%)
EGF_CA 282..322 CDD:214542 9/39 (23%)
EGF_3 328..366 CDD:289699 6/37 (16%)
EGF 430..457 CDD:278437 10/26 (38%)
EGF_CA 469..503 CDD:238011 12/34 (35%)
CUB 509..622 CDD:238001 33/186 (18%)
CUB 627..737 CDD:238001 33/162 (20%)
CUB 744..849 CDD:294042 21/110 (19%)
CUB 853..970 CDD:238001 22/139 (16%)
CUB 978..1094 CDD:238001 31/151 (21%)
CUB 1100..1211 CDD:238001 30/147 (20%)
CUB 1216..1330 CDD:238001 30/183 (16%)
CUB 1446..1549 CDD:238001 25/170 (15%)
CUB 1554..1667 CDD:238001 32/176 (18%)
CUB 1792..1899 CDD:238001 22/129 (17%)
CUB 1910..1998 CDD:294042 17/103 (17%)
CUB 2019..2133 CDD:238001 17/114 (15%)
CUB 2140..2242 CDD:238001 26/125 (21%)
CUB 2263..2379 CDD:238001 19/91 (21%)
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
svep1XP_012808841.2 vWFA_subfamily_ECM 74..236 CDD:238727
Ephrin_rec_like 302..352 CDD:311571
PHA02927 <365..550 CDD:222943
CCP 430..486 CDD:153056
HYR 552..634 CDD:367105
DUF5011 646..716 CDD:383419
Ephrin_rec_like 1008..1055 CDD:311571
Ephrin_rec_like 1062..1109 CDD:311571
Ephrin_rec_like 1116..1163 CDD:311571 4/6 (67%)
EGF_CA 1198..1232 CDD:238011 13/33 (39%)
EGF_CA 1235..1270 CDD:238011 12/39 (31%)
EGF_CA 1272..1308 CDD:238011 8/44 (18%)
EGF_CA 1311..1346 CDD:238011 18/83 (22%)
EGF_CA 1348..1384 CDD:238011 15/90 (17%)
EGF_CA 1386..1422 CDD:238011 12/38 (32%)
LamG 1422..1625 CDD:389952 39/214 (18%)
Sushi 1631..1688 CDD:365861 12/57 (21%)
CCP 1693..1746 CDD:214478 11/59 (19%)
EGF_CA 1748..1786 CDD:214542 8/43 (19%)
PHA02927 <1791..1961 CDD:222943 36/210 (17%)
PHA02639 1904..>2082 CDD:165022 40/213 (19%)
PHA02927 2081..2322 CDD:222943 61/300 (20%)
PHA02817 2321..>2439 CDD:165167 17/120 (14%)
PHA02927 2404..2612 CDD:222943 33/212 (16%)
PHA02927 2518..2773 CDD:222943 45/271 (17%)
CCP 2777..2830 CDD:214478 10/53 (19%)
PHA02927 2830..3061 CDD:222943 53/291 (18%)
CCP 3066..3119 CDD:214478 10/57 (18%)
PHA02927 3119..3355 CDD:222943 61/369 (17%)
PHA02927 3257..3470 CDD:222943 48/230 (21%)
PHA02927 3366..3586 CDD:222943 21/98 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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