Protein Alignment Cubn and neto2b

DIOPT Version :10

• Sequence 1: NP_727348.2
• Gene: Cubn / 326235
• FlyBaseID: FBgn0052702
• Length: 3750
• Species: Drosophila melanogaster
• Sequence 2: XP_021323426.1
• Gene: neto2b / 100034584
• ZFINID: ZDB-GENE-060503-638
• Length: 537
• Species: Danio rerio
• Alignment Length: 598
• Identity: 128/598 - (21%)
• Similarity: 212/598 - (35%)
• Gaps: 174/598 - (29%)

  Fly   495 PGYRGRLCETR----FSSCNGMLSAQSGRLRYPPEGTGYEHNAQCAWVIRTNESLVVNVTFNS-F 554
            |.:.|.|.:|.    |||.|           ||   :.|..|.:|.:::..:....:.:.|:. :
Zfish    36 PAHCGTLVQTENGGTFSSPN-----------YP---STYPPNKECVYILEAHPRKRIQLVFDDIY 86

  Fly   555 DVEDSTECRFDWLQINDGRSAAAQIIGRYCGNHLPHGGNIVSSGNQLYLWFRSDNSTAKEGFDLT 619
            .:|.|.|||||.::|.||....:.:|.|:||:..|  |.:.|||..|::.|.||....:.||.:.
Zfish    87 HIEPSFECRFDNIEIRDGPFIFSPLINRFCGDKSP--GIVTSSGRFLWIKFTSDEELEELGFKVE 149

  Fly   620 WN-SMEP----QCGGRLN------FETHGTLASPGSPGNYPKNR-------DCRWQLVAPTTKRI 666
            :: :.:|    ..||.||      ||..|......|.....:|:       ||.|.:.||...:|
Zfish   150 YSYTADPDFHLHVGGLLNPIPDCQFEMSGADGVIRSSQVEEENKVKAGEAVDCIWTIRAPPMSKI 214

  Fly   667 KLTFFSLQLEQHANCNFDYVLIKDSISGRE--LAKYCTTGAPAPLLLPTHLAEIHFHSDAEGSDT 729
            .|.|...|||....|..::|.:.:..:..|  .||:|:|.| ..:.|...:|.:...:|.....:
Zfish   215 YLRFLDYQLENSNECKKNFVAVYEGSNAIEDLKAKFCSTVA-NDITLDNTVAVVRMWADETSKLS 278

  Fly   730 GFQLHYSVEERVPGCGGVYTAKEGTISESSTANTEPGGVSCEYEIHLAVGEQVV---IQFARLEL 791
            .|:|.::|... |.|                   .|....|  ..::.:...:|   :|......
Zfish   279 RFRLLFTVFTE-PPC-------------------SPNAYFC--HSNMCINNTLVCNGVQNCVFPW 321

  Fly   792 DPLDCLEVLDITDEGGSILQEKICGSDASRLNPPTFTSEFNRLKIKFYARAGSFQLNYRMACDYK 856
            |..:|              :||         .|.||.                          ::
Zfish   322 DENNC--------------REK---------KPKTFF--------------------------HQ 337

  Fly   857 LNNEQGTI--TSPGYPNL------------TRSDRICTYTISTATNTVISLKRIDFQLTNGESDD 907
            ::...||:  .|.|...|            .|...:|...:.:||.....:...::::.:.: |.
Zfish   338 MSKTHGTVIGVSTGVVCLLLIISIFIQMKQPRKKILCRKGLFSATEMQEVMDPPEYEMFSMQ-DT 401

  Fly   908 DDNDECLTTNLRINDGL---------NRKILGPYCGKNQPEENFVSETNYLQLHLSTDVDSMGRG 963
            |..:|.|...|   :||         :|.|...:||.:......::.||.|...|||
Zfish   402 DMPEELLEEEL---EGLQKLHRSASMSRCIREHHCGAHNSTTILMTRTNPLSEELST-------- 455

  Fly   964 FKFEYRALATGNDKCGGVHTRSGDHIRLPVHDDSYAGEATCYWVIMAPANKAIR--LHWNSFSLE 1026
                    |.|....|..|.|.........|..:|:.:             ::|  |..:..|||
Zfish   456 --------AVGARSWGSFHGRRSSSRSHHPHTHAYSAQ-------------SLREALEEDELSLE 499

  Fly  1027 NAVDCIYDYLEIY 1039
            ..|.....|.|::
Zfish   500 GQVMEEIGYNEVF 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn	NP_727348.2	cubilin_NTD	21..149	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	282..322	CDD:214542
		EGF_CA	324..367	CDD:214542
		EGF	430..457	CDD:394967
		EGF_CA	469..503	CDD:238011	3/7 (43%)
		CUB	509..622	CDD:238001	32/114 (28%)
		CUB	627..737	CDD:238001	33/124 (27%)
		CUB	744..849	CDD:412131	12/107 (11%)
		CUB	853..970	CDD:238001	26/139 (19%)
		CUB	978..1094	CDD:238001	13/64 (20%)
		CUB	1100..1211	CDD:238001
		CUB	1216..1330	CDD:238001
		CUB	1446..1549	CDD:238001
		CUB	1554..1667	CDD:238001
		CUB	1792..1899	CDD:238001
		CUB	1910..1998	CDD:412131
		CUB	2019..2133	CDD:238001
		CUB	2140..2242	CDD:238001
		CUB	2263..2379	CDD:238001
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:412131
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001
		CUB	3254..3363	CDD:238001
		CUB	3379..3508	CDD:238001
		CUB	3531..3601	CDD:412131
		CUB	3623..3733	CDD:238001
neto2b	XP_021323426.1	CUB	39..151	CDD:238001	38/127 (30%)
		CUB	<200..286	CDD:238001	24/86 (28%)
		LDLa	292..326	CDD:238060	6/54 (11%)