DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango5 and VMP1

DIOPT Version :9

Sequence 1:	NP_001162716.1	Gene:	Tango5 / 326232	FlyBaseID:	FBgn0052675	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001316324.1	Gene:	VMP1 / 81671	HGNCID:	29559	Length:	419	Species:	Homo sapiens

Alignment Length:	421	Identity:	213/421 - (50%)
Similarity:	292/421 - (69%)	Gaps:	32/421 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 MQETGSSATSLLAAGGKAKKN-------QKDKQRERERLERGQLVLWRRPLQTTKYCGLELFTLL 160
            |.|.|.:......|..|...|       ..::::.|||.||..:||||:||.|.:|..||:..:|
Human     1 MAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVIL 65

  Fly   161 RTWSTRLLQQRLLLATLIVLSIVFSVIYKIDGPHQLAIEFVRRNTWFFVYWLGLGVLSSVGLGTG 225
            :.|:::|..::.::.:.::|..|....|.::|.||..::.:.:....:.||:|||:|||||||||
Human    66 KEWTSKLWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTG 130

  Fly   226 LHTFLLYLGPHIASVTLAAYECNSLRFPQPPYPDDIICPEEPYDKHVPNIWSIMSKVRLEAFLWG 290
            ||||||||||||||||||||||||:.||:|||||.||||:|...:...::|||:||||:||.:||
Human   131 LHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWG 195

  Fly   291 AGTALGELPPYFMAKAARLSGYDPEDAEELAEFEAL--NAKRHQKNLSMMDRGKLFMERVVERVG 353
            .|||:|||||||||:||||||.:|:| ||..|||.:  :|:..|   ....|.||.::::|::||
Human   196 IGTAIGELPPYFMARAARLSGAEPDD-EEYQEFEEMLEHAESAQ---DFASRAKLAVQKLVQKVG 256

  Fly   354 FFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAVIKMHIQKIFVIIAFNETLIERAV 418
            |||||||||||||||||||||||||||||||||||||||||:||||||||||||.|::.::|:.|
Human   257 FFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMV 321

  Fly   419 DLL-------------ATLPVLGHKLQEPFKSFLKNQKQRLHRQQRGAAGATTGAGDSGNLLSRI 470
            ..:             :.:|.:|..||:||:.:|:.|:|:||.:      :..|.....|.||.:
Human   322 AFIGLEDNGALQPPPPSAVPGIGPSLQKPFQEYLEAQRQKLHHK------SEMGTPQGENWLSWM 380

  Fly   471 FETFVIGMVCYFVVSIVNSLAQSYHKRLHKK 501
            ||..|:.|||||::||:||:||||.||:.::
Human   381 FEKLVVVMVCYFILSIINSMAQSYAKRIQQR 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango5	NP_001162716.1	SNARE_assoc	<346..395	CDD:294297	43/48 (90%)
VMP1	NP_001316324.1	SNARE_assoc	<247..298	CDD:294297	43/50 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160280
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1109
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23686
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1722
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54823
OrthoDB	1	1.010	-	-		D468248at33208
OrthoFinder	1	1.000	-	-		FOG0003786
OrthoInspector	1	1.000	-	-		oto90510
orthoMCL	1	0.900	-	-		OOG6_103371
Panther	1	1.100	-	-	LDO	PTHR10281
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2897
SonicParanoid	1	1.000	-	-		X2641
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800