DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango5 and Vmp1

DIOPT Version :9

Sequence 1:	NP_001162716.1	Gene:	Tango5 / 326232	FlyBaseID:	FBgn0052675	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001343460.1	Gene:	Vmp1 / 75909	MGIID:	1923159	Length:	406	Species:	Mus musculus

Alignment Length:	410	Identity:	216/410 - (52%)
Similarity:	291/410 - (70%)	Gaps:	23/410 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 MQETGSSATSLLAAGGKAKKN---------QKDKQRERERLERGQLVLWRRPLQTTKYCGLELFT 158
            |.|.|.:......|..|.:.|         .:.|:|:||  ||..:||||:||.|.:|..||...
Mouse     1 MAENGKNCDQRRIAMSKDQHNGSLTDPSSVHEKKRRDRE--ERQNIVLWRQPLITLQYFSLETLV 63

  Fly   159 LLRTWSTRLLQQRLLLATLIVLSIVFSVIYKIDGPHQLAIEFVRRNTWFFVYWLGLGVLSSVGLG 223
            :|:.|:::|..::.::.:.::|.......|.::|.||..::.:.:....:.||:|||:|||||||
Mouse    64 VLKEWTSKLWHRQSIVVSFLLLLAALVATYYVEGAHQQYVQRIEKQFLLYAYWIGLGILSSVGLG 128

  Fly   224 TGLHTFLLYLGPHIASVTLAAYECNSLRFPQPPYPDDIICPEEPYDKHVPNIWSIMSKVRLEAFL 288
            ||||||||||||||||||||||||||:.||:|||||.||||||...:...::|||:||||:||.:
Mouse   129 TGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPEEEGAEGAISLWSIISKVRIEACM 193

  Fly   289 WGAGTALGELPPYFMAKAARLSGYDPEDAEELAEFEAL--NAKRHQKNLSMMDRGKLFMERVVER 351
            ||.|||:|||||||||:||||||.:|:| ||..|||.:  :|:..|   ....|.||.::::|::
Mouse   194 WGIGTAIGELPPYFMARAARLSGAEPDD-EEYQEFEEMLEHAEAAQ---DFASRAKLAVQKLVQK 254

  Fly   352 VGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAVIKMHIQKIFVIIAFNETLIER 416
            |||||||||||||||||||||||||||||||||||||||||||:|||||||||||:.|::.::|:
Mouse   255 VGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIVTFSKHIVEQ 319

  Fly   417 AVDLLATLPVLGHKLQEPFKSFLKNQKQRLHRQQRGAAGATTGAGDSGNLLSRIFETFVIGMVCY 481
            .|..:..:|.:|..||:||:.:|:.|:|:||  .|..||...|.    |.||.:||..|:.||||
Mouse   320 MVTFIGAVPGIGPSLQKPFQEYLEAQRQKLH--HRSEAGTPQGE----NWLSWMFEKLVVAMVCY 378

  Fly   482 FVVSIVNSLAQSYHKRLHKK 501
            ||:||:||:||:|.||:.::
Mouse   379 FVLSIINSMAQNYAKRIQQR 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango5	NP_001162716.1	SNARE_assoc	<346..395	CDD:294297	43/48 (90%)
Vmp1	NP_001343460.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		7/35 (20%)
		VTT domain. /evidence=ECO:0000250\|UniProtKB:Q96GC9	173..316		97/146 (66%)
		SNARE_assoc	<247..298	CDD:412374	43/50 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850632
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1109
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23686
Inparanoid	1	1.050	429	1.000	Inparanoid score	I1719
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54823
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003786
OrthoInspector	1	1.000	-	-		oto94099
orthoMCL	1	0.900	-	-		OOG6_103371
Panther	1	1.100	-	-	LDO	PTHR10281
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2897
SonicParanoid	1	1.000	-	-		X2641
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790