DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and ACTR8

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_075050.3	Gene:	ACTR8 / 93973	HGNCID:	14672	Length:	624	Species:	Homo sapiens

Alignment Length:	473	Identity:	91/473 - (19%)
Similarity:	172/473 - (36%)	Gaps:	150/473 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 HVDDLMVGDEASQLRSL--LEVSYPMENG-----------VVRNWDDMCHVWDYTFGPKKMDI-- 105
            |..:.:||:||..:..|  ..:.:|:..|           :.....|:..:|.:.. .|.::|
Human   161 HHPEYLVGEEALYVNPLDCYNIHWPIRRGQLNIHPGPGGSLTAVLADIEVIWSHAI-QKYLEIPL 224

  Fly   106 -DPTNTKILLTEPPMNPTKNREKMIEVMFEKYGFDSAYIAIQAVLTLYAQGLISGVVIDSGDGVT 169
             |....:.:|..|.:...::.::::.::..|.||....:..::|...|..||.|..::|.||..|
Human   225 KDLKYYRCILLIPDIYNKQHVKELVNMILMKMGFSGIVVHQESVCATYGSGLSSTCIVDVGDQKT 289

  Fly   170 HICPVYEEFALPHLTRRLDIA--GRDITRYLIKLLLLRGYAF-----NHSADFETVRIMKEKLCY 227
            .:|.|  |..:.|...||.:|  |.|::|....|:...|:.:     .:..|...::.:||..|:
Human   290 SVCCV--EDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMDCLLLQHLKETFCH 352

  Fly   228 IGYDI------EMEQRLALETTVLVESYTLPDGRVIKVGGERFEAPEALFQPHLINVEGPGIAEL 286
            :..||      |.:.|......:|.:         .::|.|:.:||.|||.|....:.|..:..|
Human   353 LDQDISGLQDHEFQIRHPDSPALLYQ---------FRLGDEKLQAPMALFYPATFGIVGQKMTTL 408

  Fly   287 AFNT------------------------------------------IQAADIDIRPELYKHIV-- 307
            ...:                                          ::....|:...|:...|
Human   409 QHRSQGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIGFEGDLRGQSSDLPERLHSQEVDL 473

  Fly   308 -------LSGGSTMYPGLPSRLER-------EIKQLYLERVL--------KNDTEK--------- 341
                   |..|:.....|.:.:.|       |.|.|.|::.:        .:||:|
Human   474 GSAQGDGLMAGNDSEEALTALMSRKTAISLFEGKALGLDKAILHSIDCCSSDDTKKKMYSSILVV 538

  Fly   342 -----------LAKFKIRIEDPP-------------RRKDM-----VFIGGAVLA--EVTKDRDG 375
                       ..:.:|..:.||             |.|||     .:.||||||  :.|::
Human   539 GGGLMFHKAQEFLQHRILNKMPPSFRRIIENVDVITRPKDMDPRLIAWKGGAVLACLDTTQE--- 600

  Fly   376 FWMSKQEYQEQGLKVLQK 393
            .|:.::|:|..|:::|::
Human   601 LWIYQREWQRFGVRMLRE 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	91/471 (19%)
ACTR8	NP_075050.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		NBD_sugar-kinase_HSP70_actin	162..619	CDD:388382	90/472 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..462		0/31 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810