DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and ARP2

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_010255.1	Gene:	ARP2 / 851532	SGDID:	S000002187	Length:	391	Species:	Saccharomyces cerevisiae

Alignment Length:	387	Identity:	254/387 - (65%)
Similarity:	302/387 - (78%)	Gaps:	4/387 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NVIVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIGDIEVKDLHVDDLMVGDEASQLRS 71
            |.||.|.||||||.|.||.|||.:.|||:||||::||..:..    ....:.|:|:|||||::||
Yeast     5 NPIVLDQGTGFVKIGRAGENFPDYTFPSIVGRPILRAEERAS----VATPLKDIMIGDEASEVRS 65

  Fly    72 LLEVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNREKMIEVMFEKY 136
            .|::|||||||:::||.||..:|||.|..:......:|.|||||||||||.||||||.|||||||
Yeast    66 YLQISYPMENGIIKNWTDMELLWDYAFFEQMKLPSTSNGKILLTEPPMNPLKNREKMCEVMFEKY 130

  Fly   137 GFDSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAGRDITRYLIKL 201
            .|...|:||||||.||||||.||||:|||||||||.||||...|.|||||||:||||:||:||.|
Yeast   131 DFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLSHLTRRLDVAGRDVTRHLIDL 195

  Fly   202 LLLRGYAFNHSADFETVRIMKEKLCYIGYDIEMEQRLALETTVLVESYTLPDGRVIKVGGERFEA 266
            |..||||||.:|||||||.:||||||:.||::::.:||.|||.|||||.|||||.||||.|||||
Yeast   196 LSRRGYAFNRTADFETVRQIKEKLCYVSYDLDLDTKLARETTALVESYELPDGRTIKVGQERFEA 260

  Fly   267 PEALFQPHLINVEGPGIAELAFNTIQAADIDIRPELYKHIVLSGGSTMYPGLPSRLEREIKQLYL 331
            ||.||||.|::||.||:.||.|||:|:||:|||..|||.|||||||:||||||||||:|:|||:.
Yeast   261 PECLFQPGLVDVEQPGVGELLFNTVQSADVDIRSSLYKAIVLSGGSSMYPGLPSRLEKELKQLWF 325

  Fly   332 ERVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGFWMSKQEYQEQGLKVLQK 393
            .|||.||..:|.|||:|||||||||.||||||||||.:..|:|..|:||||:||.|...:.|
Yeast   326 SRVLHNDPSRLDKFKVRIEDPPRRKHMVFIGGAVLASIMADKDHMWLSKQEWQESGPSAMTK 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	253/385 (66%)
ARP2	NP_010255.1	ACTIN	4..387	CDD:214592	253/385 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	516	1.000	Domainoid score	I43
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4181
Inparanoid	1	1.050	517	1.000	Inparanoid score	I196
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54319
OrthoFinder	1	1.000	-	-		FOG0003456
OrthoInspector	1	1.000	-	-		oto100312
orthoMCL	1	0.900	-	-		OOG6_102757
Panther	1	1.100	-	-	LDO	PTHR11937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R82
SonicParanoid	1	1.000	-	-		X2348
TreeFam	1	0.960	-	-
	14	13.860